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Now showing items 41-50 of 52
Mitochondrial H₂O₂ emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
(2009-03)
High dietary fat intake leads to insulin resistance in skeletal muscle, and this represents a major risk factor for type 2 diabetes and cardiovascular disease. Mitochondrial dysfunction and oxidative stress have been ...
American Ginseng Modifies 137Cs-Induced DNA Damage and Oxidative Stress in Human Lymphocytes
(East Carolina University, 2009-01-01)
The multifold bioactive medicinal properties of ginseng have been closely linked to its antioxidative ability, which is related to its ginsenoside content. Since the key mechanism of radiation-induced cell death and tissue ...
Some Cardiomyopathy-Causing Troponin I Mutations Stabilize a Functional Intermediate Actin State
(East Carolina University, 2009-03-18)
We examined four cardiomyopathy-causing mutations of troponin I that appear to disturb function by altering the
distribution of thin filament states. The R193H (mouse) troponin I mutant had greater than normal actin-activated ...
The Role of Axl and Axl-like Proteins in Murine Spermatogenesis
(East Carolina University, 2009)
Mice lacking the Axl receptor tyrosine kinase (RTK) and its family members exhibit detrimental effects on their reproductive ability. AXL is localized to Sertoli cells, which are the major nurturing cells in the seminiferous ...
The Distribution Of Regulated Actomyosin States Is Central To Cardiac Muscle Regulation And Disturbance Of This Distribution Leads To Congenital Cardiomyopathies
(East Carolina University, 2009)
Hypertrophic and restrictive cardiomyopathies are congenital cardiac diseases that have an incidence of over one in five hundred and may lead to sudden cardiac death. One of the main impediments to directed treatment is ...
Chronic ethanol attenuates centrally-mediated hypotension elicited via alpha-2-adrenergic, but not I1-imidazoline, receptor activation in female rats
(East Carolina University, 2009-01-16)
Aims—This study dealt with the effect of chronic ethanol administration on hemodynamic responses
elicited by α2-adrenergic (α-methyldopa) or I1-imidazoline (rilmenidine) receptor activation in
telemetered female rats.
Main ...
Estrogen-dependent enhancement of NO production in the nucleus tractus solitarius contributes to ethanol-induced hypotension in conscious female rats
(East Carolina University, 2009-02)
Background- Our previous pharmacological and cellular studies showed that peripheral (cardiac and vascular) NOS-derived NO is implicated in the estrogen-dependent hypotensive action of ethanol in female rats. The objective ...
Pitt County Memorial Hospital Plays a Role in the Eat Smart Move More North Carolina Movement
(2009)
Pitt County Memorial Hospital is taking the "Journey to Excellence" and as part of that journey, is creating a culture of wellness. This paper describes those efforts as well as the criteria for healthy food. Data ...
Bone marrow stromal cells attenuate sepsis via prostaglandin E2— dependent reprogramming of host macrophages to increase their interleukin-10 production
(East Carolina University, 2009-01)
Sepsis causes over 200,000 deaths yearly in the US; better treatments are urgently needed. Administering bone marrow stromal cells (BMSCs—also known as mesenchymal stem cells) to mice before or shortly after inducing sepsis ...
Take Off 4-Health Healthy Lifestyle Camp Nutrition Education Curriculum
(2009-06-09)
Summer camps designed to produce weight loss are popular childhood obesity interventions. Nutrition education is a critical component of youth weight loss camps and we will present the curriculum developed for a 3 week ...