Browsing Biochemistry and Molecular Biology by Author "Chalovich, Joseph"
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The C-terminus of Troponin T Modulates Calcium Regulation of Actin-Myosin Interactions
Johnson, Dylan James (East Carolina University, 2019-05-02)The highly conserved terminal fourteen C-terminal residues of troponin T play a novel role in the regulation of striated muscle contraction. Elimination of the terminal fourteen residues of the C-terminal region of troponin ... -
Tropomyosin Dynamics in Cardiac Thin Filaments: A Multisite Förster Resonance Energy Transfer and Anisotropy Study
Wang, Hui; Mao, Shu; Chalovich, Joseph; Marriott, Gerard (East Carolina University, 2008-06)Cryoelectron microscopy studies have identified distinct locations of tropomyosin (Tm) within the Ca21-free, Ca21-saturated, and myosin-S1-saturated states of the thin filament. On the other hand, steady-state Förster ... -
Troponin-tropomyosin: an allosteric switch or a steric blocker?
Resetar, Andrea M.; Stephens, Jacqueline M.; Chalovich, Joseph (East Carolina University, 2002-08)The interaction of myosin subfragment 1 (S1) with actin-tropomyosin-troponin (regulated actin) is highly nucleotide dependent. The binding of S1 or S1-ADP (but not S1-ATP nor N,N - -phenylenedimaleimide-modified S1-ATP) ...