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Molecular mechanisms of TMEFF2 action in Prostate Cancer
(East Carolina University, 2013)
The transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) is an evolutionarily conserved type I transmembrane protein expressed in the embryo and limited adult tissues, mainly the brain ...
N-3 polyunsaturated fatty acids differentially enhance B-cell mediated immunity in lean and obese mice
(East Carolina University, 2014)
Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are
bioactive n-3 polyunsaturated fatty acids (PUFAs) in fish oil that
exert immunomodulatory effects. The general paradigm suggests n-3
PUFAs exert immunosuppressive ...
Novel diagnostic and analytical applications of benchtop time-domain NMR.
(East Carolina University, 2015)
High-resolution nuclear magnetic resonance (NMR) spectroscopy is a powerful technique, yet practical application outside of the research laboratory has been limited due to the high cost and complexity of the instrumentation. ...
Retinoids Potentiate Clinically Relevant Cellular Responses through RARα/RXR Nuclear Receptor Synergism in Cutaneous T Cell Lymphoma
(East Carolina University, 2015-12-15)
The heterogeneity of cutaneous T cell lymphoma (CTCL) has stifled treatment options and hindered cure development. Despite the heterogeneous nature of CTCLs, a hallmark of all variants is malignant T cell infiltration of ...
The involvement of cap-independent mRNA translation in cell fate decisions
(East Carolina University, 2014)
During cell stress many biochemical processes are shut down. For
example, global mRNA translation initiation is inhibited due to the
disruption of the cap-dependent mRNA recruitment mechanism. One
specific example of ...