Browsing by Author "Ables, Elizabeth Tweedie"
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Adamts9 is critical for the development of primary ovarian follicles
Carver, Jonathan Jacob (East Carolina University, 2022-07-19)Adamts9 (a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 9) is an extracellular matrix metalloprotease that is highly evolutionarily conserved and critical for development in vertebrates. ... -
Characterizing the Role of Pectin in Cell Wall Composition and Organ Initiation in Maize
Maynard, Daniel Jarrell (East Carolina University, 2022-12-07)Plants are constantly developing new organs throughout their life and these organs arise from stem cell pools called meristems. Organ primordia are generated on the flanks of meristems when stem cells differentiate into ... -
Characterizing the role of the Early Gene at 23 (E23) in Drosophila Melanogaster Oogenesis
Kothadia, Radhika J (East Carolina University, 2016-04-29)Drosophila melanogaster (fruit fly) females undergo oogenesis to create oocytes from undifferentiated stem cells in the ovary. Similar to estrogen in humans, the steroid hormone ecdysone in fruit flies has a known role in ... -
Characterizing the subcellular localization and function of Citron Kinase in the germline of Drosophila melanogaster
Porter, Kyra M. (East Carolina University, 2023-05-02)Cytokinesis, or the final division of cells, is a conserved and highly regulated process that is crucial for all multicellular organisms. Errors in cytokinesis are linked to a variety of maladies, including microcephaly ... -
Determining the role of the steroid hormone ecdysone in critical stages of Drosophila melanogaster early oogenesis
Finger, Danielle S. (East Carolina University, 2019-11-27)Reproductive function in many organisms, including Drosophila melanogaster, is controlled by steroid hormones. The main steroid hormone in Drosophila is ecdysone, which is structurally and functionally similar to estrogen. ... -
Development of an Optogenetic Tool for Targeted Sensory Hair Cell Ablation in Zebrafish
Cedrone, Alexandria (East Carolina University, 2022-04-28)Mechanosensory hair cells convert mechanical information into neuronal signals. Mutations in the genes required for hair cell function cause deafness and lead to the degeneration of sensory hair cells. Mammals are unable ... -
Drosophila Oocytes as a Model for Understanding Meiosis: An Educational Primer to Accompany “Corolla Is a Novel Protein That Contributes to the Architecture of the Synaptonemal Complex of Drosophila”
Ables, Elizabeth Tweedie (2015-01)Achieving a thorough understanding of the events and ramifications of meiosis is a common learning objective for undergraduate introductory biology, genetics, and cell biology courses. Meiosis is also one of the most ... -
Drosophila Ovarian Stem Cell Establishment is Regulated by Nuclear Hormone Receptor ftz-f1
Berghout, Hanna E. (East Carolina University, 2017-06-28)Stem cells are a fundamental underpinning of tissue biology. Loss of the self-renewing function of stem cells leads to conditions such as infertility and tissue wasting. Stem cells integrate a variety of signals to maintain ... -
Environmental Development of the External Genitalia
Maurizio, Ciro (East Carolina University, 2018-07-24)Hypospadias is one of the most common birth defects in the world. The incidence of hypospadias has nearly doubled over the past 50 years and now occurs on average in 1 in 125 male newborns each year. Hypospadias is a ... -
A Genetic Mosaic Screen Reveals Ecdysone-Responsive Genes Regulating Drosophila Oogenesis
Ables, Elizabeth Tweedie; Hwang, Grace H.; Finger, Danielle S.; Hinnant, Taylor D.; Drummond-Barbosa, Daniela (2016-08)Multiple aspects of Drosophila oogenesis, including germline stem cell activity, germ cell differentiation, and follicle survival, are regulated by the steroid hormone ecdysone. While the transcriptional targets of ecdysone ... -
Genetic regulation of maize floral development - insights from the transcriptome and translatome
Yang, Hailong (East Carolina University, 2022-06-24)Flowers are produced by floral meristems, groups of stem cells that give rise to floral organs. In grasses, including the major cereal crops, flowers (florets) are contained in spikelets, which contain one to many florets, ... -
INVESTIGATING THE MOLECULAR CONTROL OF ECDYSONE RESPONSE GENE, E74, IN THE DROSOPHILA OVARY.
Davenport, Lindsay L (East Carolina University, 2017-05-05)Oogenesis is the process by which an egg develops from precursor cells in the ovary. This process has been widely studied; however, many of the molecular mechanisms that regulate oocyte development and growth remain unclear. ... -
Investigating the Role of CG8093 in Drosophila Female Germline Stem Cells
Cavallero, Michael Louis (East Carolina University, 2023-05-03)Cell division and differentiation are imperative for the maintenance of living organisms. Germ cells, which serve as the progenitor cells necessary to create oocytes and sperm, are maintained in many organisms by the ... -
Investigating the role of CRL5, an ubiquitin ligase, in ovarian follicle development.
Hardy, Victoria L (East Carolina University, 2016-07-20)During oogenesis, follicle cells surround maturing oocytes, which produce factors necessary for proper oocyte growth and development. Correct encapsulation of the oocyte by follicle cells is therefore essential for ... -
Investigating the Role of Ecdysone Receptor in Germline to Somatic Cell Communication
Swain, Lindsay (East Carolina University, 2023-12-04)Oogenesis requires complex coordination between both somatic and germ cell populations, relying on systemic signals such as hormones for proper oocyte production and formation. Drosophila melanogaster is an excellent model ... -
Investigating the role of TER94 in Drosophila melanogaster germ cells
Gowdy, Alyssa Celine (East Carolina University, 2021-05-28)Mutations in Valosin-Containing Protein (VCP) can lead to onset of Amyotrophic Lateral Sclerosis, a fatal neurodegenerative disease; however, the intracellular functions of VCP in cells remain unclear. To study the ... -
Investigating the role of transcription factor, Trl, during germline development in the Drosophila ovary
Davenport, Lindsay L (East Carolina University, 2019-07-22)Oogenesis is the process by which an egg develops from undifferentiated cells in the ovary. The Drosophila melanogaster ovary is an assembly line for egg production, making it a great system to investigate initial oocyte ... -
Mechanisms of germ cell development in Drosophila oogenesis.
Hinnant, Taylor D. (East Carolina University, 2018-07-17)Germ cell development requires interplay between factors that control cell fate and division. Early in their development, germ cells are an interconnected group of mitotically dividing cells. Key regulatory events then ... -
Molecular chaperone Tetratricopeptide repeat protein 2 (Tpr2) is essential for germline stem cell self-renewal and timely cyst divisions in Drosophila melanogaster oogenesis
Phillips, Morgan L (East Carolina University, 2019-05-02)Steroid hormones influence cell proliferation and cell fate in developing and injured tissues. Although steroid hormone signaling has been well-studied, the precise mechanisms by which cells specifically receive steroid ... -
Myocardial Implications in Renin Angiotensin Aldosterone-Regulated Hypertension
Byrum, Rachel (East Carolina University, 2023-08-08)Hypertension is a prevalent and potentially deadly disease that affects approximately 116 million (47%) adults diagnosed in the U.S. as reported by the CDC in 2017. Understanding mechanisms responsible for high blood ...