Browsing by Author "Anatomy and Cell Biology"
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A QUEST FOR ARTICULAR CARTILAGE PROGENITOR CELLS LEADS TO TEMPORAL REGULATION OF HYALURONAN REQUIRED FOR 3T3-L1 ADIPOGENESIS
Sellers, Samantha Sue (East Carolina University, 2017-07-13)During embryogenesis, mesenchymal progenitor cells exhibit hyaluronan-dependent pericellular matrices as a major component of the extracellular matrix. As connective tissues form by cellular condensations, there is a loss ... -
ANALYSIS OF TRANSGENIC MOUSE MODELS TO STUDY MAMMALIAN SPERMATOGONIA
Kirsanov, Oleksandr (East Carolina University, 2018-07-24)Spermatogenesis in the mammalian testis results in the daily production of millions of spermatozoa. This developmental process is founded upon the actions of a small population of spermatogonial stem cells (SSCs). As SSCs ... -
CD44 and hyaluronan promote the bmp7 signaling response in chondrocytes
Luo, Na (East Carolina University, 2011)Cell-matrix interactions are important in maintaining cartilage homeostasis. Hyaluronan binding to its principal receptor CD44 is essential for such interactions. Hyaluronan-CD44 interactions are required for the retention ... -
Colocalization of Known Focal Adhesion Proteins and Novel Focal Adhesion Protein GPR98 in Human Neurites during Neuronal Development in 2 and 3 Dimensions
Petritsch, Amanda (East Carolina University, 2022-07-29)Focal adhesions are critical to cell motility, morphology, and neuronal circuit formation. Proper neuronal circuit formation relies on neurons reaching the right location, assuming a specific morphology, and connecting ... -
Colocalization of Known Focal Adhesion Proteins and Novel Focal Adhesion Protein GPR98 in Human Neurites during Neuronal Development in 2 and 3 Dimensions
Petritsch, Amanda Michelle (East Carolina University, 2022-07-29)Focal adhesions are critical to cell motility, morphology, and neuronal circuit formation. Proper neuronal circuit formation relies on neurons reaching the right location, assuming a specific morphology, and connecting ... -
COMPARATIVE ANALYSIS OF TESTICULAR TUMORS IN MAN AND MAN’S BEST FRIEND
Pallozzi, Megan E (East Carolina University, 2021-05-28)Testicular cancer is the most common cancer in men aged 15-35 and is thus a diagnosis that negatively impacts many men early in their lives. Testicular cancer is also quite common in dogs but comes with several differences ... -
CRISPR/Cas9 knockout of HAS2 in rat chondrosarcoma chondrocytes demonstrates the requirement of hyaluronan for aggrecan retention
Huang, Yi (East Carolina University, 2016-12-15)Hyaluronan (HA) plays an essential role in cartilage where it functions to retain aggrecan. Previous studies suggested that aggrecan is anchored indirectly to the plasma membrane of chondrocytes via its binding to ... -
[Delta]-catenin: implications in prostate cancer progression
Nopparat, Jongdee (East Carolina University, 2014)Prostate cancer (PCa) is the most commonly diagnosed cancer and the second most common cause of cancer death among men in the US. Due to the advances in research, the ability to detect and cure PCa has improved and led to ... -
Discovering mechanisms during spermatogonial differentiation that prepare male germ cells for meiosis
Johnson, Taylor A (East Carolina University, 2022-12-05)Spermatogenesis, the male germ cell maturation process, allows men to become and remain fertile for decades. Male fertility relies on fate decisions of different types of spermatogonia – spermatogonial stem cells maintain ... -
The extracellular processing of aggrecan aggregate and its effect on CD44 mediated internalization of hyaluronan.
Danielson, Ben (East Carolina University, 2015)In many cells the hyaluronan receptor CD44 mediates the endocytosis of hyaluronan and its delivery to endosomes / lysosomes. The regulation of this process remains largely unknown. In most extracellular matrices hyaluronan ... -
Functions of claudin-7 in human lung cancer
Lu, Zhe (East Carolina University, 2012)Lung cancer is the second most common cancer and the most common cause of cancer-related death in both men and women in the United States with a very poor overall 5-year survival rate. Nearly 95% of the lung cancer originates ... -
The intracellular proteolytic fragment of CD44 alters CD44 function in chondrocytes
Mellor, Liliana (East Carolina University, 2010)CD44 is an adhesion molecule involved in several biological functions and the primary receptor for hyaluronan (HA). In cartilage, CD44 participates in the interplay between cells and the extracellular matrix to fine tune ... -
INVESTIGATING MECHANISMS REGULATING MAMMALIAN SPERMATOGONIAL DIFFERENTIATION AND MEIOTIC INITIATION
Kirsanov, Oleksandr (East Carolina University, 2022-06-27)Spermatogonia differentiation and meiotic initiation are complex processes essential for male fertility. Despite knowing for nearly 60 years that retinoic acid (RA) is instrumental for successful production of functional ... -
INVESTIGATING MECHANISMS REGULATING MAMMALIAN SPERMATOGONIAL DIFFERENTIATION AND MEIOTIC INITIATION
Kirsanov, Oleksandr (East Carolina University, 2022-06-27)Spermatogonia differentiation and meiotic initiation are complex processes essential for male fertility. Despite knowing for nearly 60 years that retinoic acid (RA) is instrumental for successful production of functional ... -
Investigating Non-Tight Junction Functions of Claudin-7: Regulating Large Intestine Stem Cell Functions and Niche Maintenance, and Junctional Protein Nanoarchitecture
Naser, Amna (East Carolina University, 2022-12-12)Edit this abstract. -
Pharmacological Regulation of Neural Circuit Formation in hIPSC-Derived Neurons and ‘Mini-Brains’
Rudisill, Taylor Lee (East Carolina University, 2018-07-20)Emerging evidence suggests that altered neural connectivity, particularly at the level of synaptic connections, contributes to the pathology of many neurodevelopmental and neurodegenerative diseases. For instance, post-mortem ... -
PPP1R2 COORDINATES KINASE AND PHOSPHATASE ACTIVITY TO REGULATE THE CENTROSOME AND MIDBODY
Bresch, Alan-Michael (East Carolina University, 2021-04-21)Centrosomes are the primary microtubule organizing centers of the cell and prepare the cell for division by establishing the bipolar spindle during mitosis. A balance of kinase and phosphatase activity regulates centrosome ... -
PPP1R42 is a positive regulator of PP1 in centrosome duplication and separation and cilia dynamics
DeVaul, Nicole (East Carolina University, 2014)The centrosome is a dynamic structure that undergoes structural and functional transitions, which are coordinated with the cell cycle. It functions as the microtubule organizing center (MTOC) in interphase, duplicates and ... -
QUANTITATION OF INTERCELLULAR CONNECTIONS BETWEEN SPERMATOGONIA IN THE MOUSE
Cook, Kenneth (East Carolina University, 2017-05-09)Spermatogonial stem cells (SSCs) are critical in the male reproductive process, as they can either self-renew or proliferate into progenitor cells that differentiate to enter meiosis and eventually form functional sperm. ... -
The Role of Axl and Axl-like Proteins in Murine Spermatogenesis
Thompson, Kristjan Louise (East Carolina University, 2009)Mice lacking the Axl receptor tyrosine kinase (RTK) and its family members exhibit detrimental effects on their reproductive ability. AXL is localized to Sertoli cells, which are the major nurturing cells in the seminiferous ...