Browsing by Author "Kypson, Alan P."
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Corrigendum to “Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy” [Mol Metab 4 (6) (2015) 493–506]
Katunga, Lalage A.; Gudimell, Preeti; Efird, Jimmy T.; Abernathy, Scott; Mattox, Taylor A.; Beatty, Cherese; Darden, Timothy M.; Thayne, Kathleen A.; Alwair, Hazaim; Kypson, Alan P.; Virag, Jitka A.; Anderson, Ethan (2015) -
Discharge β-Blocker Use and Race after Coronary Artery Bypass Grafting
O'Neal, Wesley T.; Efird, Jimmy T.; Davies, Stephen W.; O'Neal, Jason B.; Griffin, William F.; Ferguson, T. Bruce; Chitwood, W. Randolph; Kypson, Alan P. (2014-04)Introduction: The use of discharge β-blockers after cardiac surgery is associated with a long-term mortality benefit. β-Blockers have been suggested to be less effective in black cardiovascular patients compared with whites. ... -
Early cell loss associated with mesenchymal stem cell cardiomyoplasty
Collins, Maria C.; Moore, Joel L. Jr; Burrows, Brian J.; Kypson, Alan P.; Muller-Borer, Barbara J. (2012-03-01)Background: Human mesenchymal stem cells (hMSCs) show potential for therapeutic cellular cardiomyoplasty. However, a range of delivery methods, including direct intramyocardial injection, have resulted in poor engraftment ... -
The effect of race and chronic obstructive pulmonary disease on long-term survival after coronary artery bypass grafting
Efird, Jimmy T.; O'Neal, Wesley T.; Anderson, Curtis A.; O'Neal, Jason B.; Kindell, Linda C.; Ferguson, T. Bruce; Chitwood, W. Randolph; Kypson, Alan P. (2013-04)Background: Chronic obstructive pulmonary disease (COPD) is a known predictor of decreased long-term survival after coronary artery bypass grafting (CABG). Differences in survival by race have not been examined. Methods: ... -
The Effect of Race and Chronic Obstructive Pulmonary Disease on Long-Term Survival after Coronary Artery Bypass Grafting
Efird, Jimmy T.; O'Neal, Wesley T.; Anderson, Curtis A.; O'Neal, Jason B.; Kindell, Linda C.; Ferguson, T. Bruce; Chitwood, W. Randolph; Kypson, Alan P. (2013-04)Background: Chronic obstructive pulmonary disease (COPD) is a known predictor of decreased long-term survival after coronary artery bypass grafting (CABG). Differences in survival by race have not been examined. Methods: ... -
Factors Associated with Discharge to a Skilled Nursing Facility after Transcatheter Aortic Valve Replacement Surgery
Horne, Carolyn E.; Goda, Tamara S.; Nifong, L. Wiley; Kypson, Alan P.; O’Neal, Wesley T.; Kindell, Linda C.; Jindal, Charulata; Efird, Jimmy T. (2018-12-28)An assumption regarding transcatheter aortic valve replacement (TAVR), a minimally invasive procedure for treating aortic stenosis, is that patients remain at, or near baseline and soon return to their presurgical home to ... -
Grand challenge: Understanding survival paradoxes in epidemiology
Efird, Jimmy T.; O’Neal, Wesley T.; Kennedy, Whitney L.; Kypson, Alan P. (2013-04-02) -
Increased Coronary Artery Disease Severity in Black Women Undergoing Coronary Bypass Surgery
Efird, Jimmy T.; O'Neal, Wesley T.; Griffin, William F.; Anderson, Ethan; Davies, Stephen W.; Landrine, Hope; O'Neal, Jason B.; Shiue, Kristin Y.; Kindell, Linda C.; Bruce Ferguson, T.; Randolph Chitwood, W.; Kypson, Alan P. (2015-02)Race and sex disparities are believed to play an important role in heart disease. The purpose of this study was to examine the association between race, sex, and number of diseased vessels at the time of coronary artery ... -
Increased Coronary Artery Disease Severity in Black Women Undergoing Coronary Bypass Surgery
Efird, Jimmy T.; O'Neal, Wesley T.; Griffin, William F.; Anderson, Ethan; Davies, Stephen W.; Landrine, Hope; O'Neal, Jason B.; Shiue, Kristin Y.; Kindell, Linda C.; Ferguson, Bruce; Chitwood, W. Randolph; Kypson, Alan P. (2015)Race and sex disparities are believed to play an important role in heart disease. The purpose of this study was to examine the association between race, sex, and number of diseased vessels at the time of coronary artery ... -
Increased Long-Term Mortality among Black CABG Patients Receiving Preoperative Inotropic Agents
Efird, Jimmy T.; Griffin, William F.; Sarpong, Daniel F.; Davies, Stephen W.; Vann, Iulia; Koutlas, Nathaniel T.; Anderson, Ethan; Crane, Patricia B.; Landrine, Hope; Kindell, Linda C.; Iqbal, Zahra J.; Ferguson, T. Bruce; Chitwood, W. Randolph; Kypson, Alan P. (2015-07)The aim of this study was to examine racial differences in long-term mortality after coronary artery bypass grafting (CABG), stratified by preoperative use of inotropic agents. Black and white patients who required ... -
Increased Long-Term Mortality among Black CABG Patients Receiving Preoperative Inotropic Agents
Efird, Jimmy T.; Griffin, William F.; Sarpong, Daniel F.; Davies, Stephen W.; Vann, Lulia; Koutlas, Nathaniel T.; Anderson, Ethan; Crane, Patricia B.; Landrine, Hope; Kindell, Linda; Iqbal, Zahra J.; Ferguson, T. Bruce; Chitwood, W. Randolph; Kypson, Alan P. (2015-07)The aim of this study was to examine racial differences in long-term mortality after coronary artery bypass grafting (CABG), stratified by preoperative use of inotropic agents. Black and white patients who required ... -
Long-Term Mortality of 306,868 Patients with Multi-Vessel Coronary Artery Disease: CABG versus PCI
Efird, Jimmy T.; O'Neal, Wesley T.; Davies, Stephen W.; Kennedy, Whitney L.; Alger, Lada N.; O'Neal, Jason B.; Ferguson, T. Bruce; Kypson, Alan P. (2013-08)Background Several randomized controlled trials (RCT) have reported no difference in long-term mortality between coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI). The purpose of this ... -
Monoamine Oxidase is a Major Determinant of Redox Balance in Human Atrial Myocardium and is Associated With Postoperative Atrial Fibrillation
Anderson, Ethan; Efird, Jimmy T.; Davies, Stephen W.; O'Neal, Wesley T.; Darden, Timothy M.; Thayne, Kathleen A.; Katunga, Lalage Adalaide; Kindell, Linda C.; Ferguson, T. Bruce; Anderson, Curtis A.; Chitwood, W. Randolph; Koutlas, Theodore C.; Williams, J. Mark; Rodriguez, Evelio; Kypson, Alan P. (2014-02)BACKGROUND: Onset of postoperative atrial fibrillation (POAF) is a common and costly complication of heart surgery despite major improvements in surgical technique and quality of patient care. The etiology of POAF, and ... -
Obesity in a model of haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy
Katunga, Lalage Adalaide; Gudimella, Preeti; Efird, Jimmy T.; Abernathy, Scott; Mattox, Taylor A.; Beatty, Cherese; Darden, Timothy M.; Thayne, Kathleen A.; Alwair, Hazaim; Kypson, Alan P.; Virag, Jitka A. I.; Anderson, Ethan (2015-04)Lipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they have a causal role has remained unclear. Glutathione peroxidase 4 (GPx4) is a selenoenzyme ... -
Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy
Katunga, Lalage A.; Gudimella, Preeti; Efird, Jimmy T.; Abernathy, Scott; Mattox, Taylor A.; Beatty, Cherese; Darden, Timothy M.; Thayne, Kathleen A.; Alwair, Hazaim; Kypson, Alan P.; Virag, Jitka A.; Anderson, Ethan (2015)Objective: Lipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they have a causal role has remained unclear. Glutathione peroxidase 4 (GPx4) is a ... -
Quantum dot labeling of mesenchymal stem cells
Muller-Borer, Barbara J.; Collins, Maria C.; Gunst, Philip R.; Cascio, Wayne E.; Kypson, Alan P. (East Carolina University, 2007-11-07)Background: Mesenchymal stem cells (MSCs) are multipotent cells with the potential to differentiate into bone, cartilage, fat and muscle cells and are being investigated for their utility in cell-based transplantation ... -
Racial differences in survival among hemodialysis patients after coronary artery bypass grafting
Efird, Jimmy T.; O’Neal, Wesley T.; Bolin, Paul Jr.; Davies, Stephen W.; O’Neal, Jason B.; Anderson, Curtis A.; Ferguson, T. Bruce; Chitwood, W. Randolph; Kypson, Alan P. (2013-09-06)The aim of this study was to examine racial differences in long-term survival among hemodialysis patients after coronary artery bypass grafting (CABG). To our knowledge this has not been previously addressed in the literature. ... -
Racial Differences in Survival among Hemodialysis Patients after Coronary Artery Bypass Grafting
Efird, Jimmy T.; O'Neal, Wesley T.; Bolin, Paul Jr.; Davies, Stephen W.; O'Neal, Jason B.; Anderson, Curtis A.; Ferguson, T. Bruce; Chitwood, W. Randolph; Kypson, Alan P. (2013-09)The aim of this study was to examine racial differences in long-term survival among hemodialysis patients after coronary artery bypass grafting (CABG). To our knowledge this has not been previously addressed in the literature. ... -
Reduction of Ischemia/Reperfusion Injury With Bendavia, a Mitochondria-Targeting Cytoprotective Peptide
Kloner, Robert A.; Hale, Sharon L.; Dai, Wangde; Gorman, Robert C.; Shuto, Takashi; Koomalsingh, Kevin J.; Gorman, Joseph H.; Sloan, Ruben C.; Frasier, Chad R.; Watson, Corinne A.; Bostian, Phillip A.; Kypson, Alan P.; Brown, David A. (2012-06) -
Risk-adjusted survival after coronary artery bypass grafting: Implications for quality improvement
Efird, Jimmy T.; O’Neal, Wesley T.; Davies, Stephen W.; O’Neal, Jason B.; Kindell, Linda C.; Anderson, Curtis A.; Chitwood, W. Randolph; Ferguson, T. Bruce; Kypson, Alan P. (2014-07-21)Mortality represents an important outcome measure following coronary artery bypass grafting. Shorter survival times may reflect poor surgical quality and an increased number of costly postoperative complications. Quality ...