Browsing by Title
Now showing items 10026-10045 of 10629
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Troponin-tropomyosin: an allosteric switch or a steric blocker?
(East Carolina University, 2002-08)The interaction of myosin subfragment 1 (S1) with actin-tropomyosin-troponin (regulated actin) is highly nucleotide dependent. The binding of S1 or S1-ADP (but not S1-ATP nor N,N - -phenylenedimaleimide-modified S1-ATP) ... -
THE TRUE ROLE OF RECESS ACCORDING TO REGULAR AND SPECIAL EDUCATORS
(East Carolina University, 2013)Due to recent trends to eliminate or reduce the time devoted towards school recess, the current study investigates the experiences and overall perceptions of school recess held by both regular and special veteran educators. ... -
Trusting Digital Preservation for Print Collection Management, Or How Librarians Should Learn to Stop Worrying and Love the "E"
(2011-09)This article advocates planning for the management of print collections in light of digital preservation activities. Three activities include deduplicating print holdings from archival online journal packages, participating ... -
Truth Behind Thames: Archaeological and Historical Investigations of the “Missionary Whaleship”
(East Carolina University, 2021-12-07)Transporting the second detachment of American missionaries to the Hawaiian Islands earned Thames its novel moniker, but this was only one of several unique distinctions it earned during its sailing career. It was the ... -
Try spicing up your diet with red pepper flakes
(2021-11-24)This is a weekly Q and A newspaper column under the byline of Dr. Kathy Kolasa. Today's column is regarding the benefits of red pepper. It has an excellent source of so many micronutrients, which are essential for survival. -
The Tub and Other Stories
(East Carolina University, 2012)This portfolio of creative writing includes four full-length short stories and two pieces of flash fiction. In each of the full-length stories, a male protagonist gets caught up in circumstances over which he has little ... -
Tumor Growth Induces Oxidative Clustered DNA Lesions Damage in Distant Mouse Tissue in vivo
(East Carolina University, 2010)Our goal was to ascertain if DNA damage induced by oxidative stress is capable of being exploited as a precancerous or cancer biomarker. The specific DNA damage that we assessed was oxidatively induced non-DSB clustered ... -
Tumor Microenvironment and Metabolism
(2017-12-16)The tumor microenvironment has profound effects on cancer development, progression, and therapeutic response. Cancer cells co-exist with infiltrated immune cells, blood vessels, fibroblasts, and other stromal cells in the ... -
Tumour necrosis factor-alpha regulates expression of the CCAAT-enhancer-binding proteins (C/EBPs) alpha and beta and determines the occupation of the C/EBP site in the promoter of the insulin-responsive glucose-transporter gene in 3T3-L1 adipocytes.
(East Carolina University, 1999-03-15)We have demonstrated previously that treatment of 3T3-L1 adipocytes with tumour necrosis factor-alpha (TNF) results in a rapid (4 h) and significant (75–80%) reduction in the rate of transcription of the GLUT4 gene. Control ... -
Tweeting the meeting: An in-depth analysis of Twitter activity at kidney week 2011
(2012-07-05)In recent years, the American Society of Nephrology (ASN) has increased its efforts to use its annual conference to inform and educate the public about kidney disease. Social media, including Twitter, has been one method ... -
Tweeting the Meeting: An In-Depth Analysis of Twitter Activity at Kidney Week 2011
(2012)In recent years, the American Society of Nephrology (ASN) has increased its efforts to use its annual conference to inform and educate the public about kidney disease. Social media, including Twitter, has been one method ... -
TWITTER AND SPORTS COMMUNICATION: THE EFFECT ON ATHLETES, ORGANIZATIONS AND THE TRADITIONAL MEDIA
(2015)Since its advent, Twitter has had a significant impact on sports communication. This essay examines the effect that Twitter has had on athletes, sports leagues and the media itself. It includes a review of recent and ... -
Two Cases of Paradoxical Hidradenitis Suppurativa while on Adalimumab
(2016)Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease characterized by recurring abscesses, nodules, and fistulas predominantly in the groin and axillae. The association between HS and Crohn’s disease (CD) ... -
Two Distinct Pathways Supply Anthranilate as a Precursor of the Pseudomonas Quinolone Signal
(East Carolina University, 2007-05)Pseudomonas aeruginosa is an opportunistic pathogen that causes serious infections in immunocompromised patients and those with cystic fibrosis (CF). This gram-negative bacterium uses multiple cell-to-cell signals to control ... -
Two hits are better than one: Targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment
(2012-05-04)Phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) are two key components of the PI3K/Akt/mTOR signaling pathway. This signal transduction cascade regulates a wide range of physiological cell ... -
Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment
(2012-04)Phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) are two key components of the PI3K/Akt/mTOR signaling pathway. This signal transduction cascade regulates a wide range of physiological cell ... -
A two-component response regulator, gltR, is required for glucose transport activity in Pseudomonas aeruginosa PAO1.
(East Carolina University, 1996-10)A 729-bp open reading frame (gltR) was identified in Pseudomonas aeruginosa PAO1 that encodes a product homologous to the two-component response regulator family of proteins. Disruption of gltR caused loss of glucose ...