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Now showing items 10032-10051 of 10629
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Tumor Growth Induces Oxidative Clustered DNA Lesions Damage in Distant Mouse Tissue in vivo
(East Carolina University, 2010)Our goal was to ascertain if DNA damage induced by oxidative stress is capable of being exploited as a precancerous or cancer biomarker. The specific DNA damage that we assessed was oxidatively induced non-DSB clustered ... -
Tumor Microenvironment and Metabolism
(2017-12-16)The tumor microenvironment has profound effects on cancer development, progression, and therapeutic response. Cancer cells co-exist with infiltrated immune cells, blood vessels, fibroblasts, and other stromal cells in the ... -
Tumour necrosis factor-alpha regulates expression of the CCAAT-enhancer-binding proteins (C/EBPs) alpha and beta and determines the occupation of the C/EBP site in the promoter of the insulin-responsive glucose-transporter gene in 3T3-L1 adipocytes.
(East Carolina University, 1999-03-15)We have demonstrated previously that treatment of 3T3-L1 adipocytes with tumour necrosis factor-alpha (TNF) results in a rapid (4 h) and significant (75–80%) reduction in the rate of transcription of the GLUT4 gene. Control ... -
Tweeting the Meeting: An In-Depth Analysis of Twitter Activity at Kidney Week 2011
(2012)In recent years, the American Society of Nephrology (ASN) has increased its efforts to use its annual conference to inform and educate the public about kidney disease. Social media, including Twitter, has been one method ... -
Tweeting the meeting: An in-depth analysis of Twitter activity at kidney week 2011
(2012-07-05)In recent years, the American Society of Nephrology (ASN) has increased its efforts to use its annual conference to inform and educate the public about kidney disease. Social media, including Twitter, has been one method ... -
TWITTER AND SPORTS COMMUNICATION: THE EFFECT ON ATHLETES, ORGANIZATIONS AND THE TRADITIONAL MEDIA
(2015)Since its advent, Twitter has had a significant impact on sports communication. This essay examines the effect that Twitter has had on athletes, sports leagues and the media itself. It includes a review of recent and ... -
Two Cases of Paradoxical Hidradenitis Suppurativa while on Adalimumab
(2016)Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease characterized by recurring abscesses, nodules, and fistulas predominantly in the groin and axillae. The association between HS and Crohn’s disease (CD) ... -
Two Distinct Pathways Supply Anthranilate as a Precursor of the Pseudomonas Quinolone Signal
(East Carolina University, 2007-05)Pseudomonas aeruginosa is an opportunistic pathogen that causes serious infections in immunocompromised patients and those with cystic fibrosis (CF). This gram-negative bacterium uses multiple cell-to-cell signals to control ... -
Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment
(2012-04)Phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) are two key components of the PI3K/Akt/mTOR signaling pathway. This signal transduction cascade regulates a wide range of physiological cell ... -
Two hits are better than one: Targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment
(2012-05-04)Phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) are two key components of the PI3K/Akt/mTOR signaling pathway. This signal transduction cascade regulates a wide range of physiological cell ... -
A two-component response regulator, gltR, is required for glucose transport activity in Pseudomonas aeruginosa PAO1.
(East Carolina University, 1996-10)A 729-bp open reading frame (gltR) was identified in Pseudomonas aeruginosa PAO1 that encodes a product homologous to the two-component response regulator family of proteins. Disruption of gltR caused loss of glucose ... -
Ty Matson: Senior Recital, Trombone
(East Carolina University, 2018-05-24)This Senior Honors Project is entitled “Ty Matson: Senior Recital, Trombone.” The author of the project is Ty Matson. The Senior Honors Project was the preparation and performance of my senior trombone recital, with program ... -
Type IQ: A Typographic Research & Design Project
(East Carolina University, 2023-04-26)While there are many facets to this creative endeavor, the core of this project is the creation of a unique typeface design, as a result of in-depth research and creative experimentation. Strong use of typography serves ... -
Type. Cast : Edition XI Brody School of Medicine Art & Literary Magazine (2018)
(2018)An art and literary magazine published by the Brody School of Medicine, Division of Health Sciences. The magazine contains artwork and writings by Brody School of Medicine's medical students and others throughout the Health ...