Browsing by Author "Anatomy and Cell Biology"
-
SPATIAL AND PLANAR DYSREGULATION OF RHOGTPASES IN HUMAN AND ALZHEIMER’S DISEASE MOUSE MODEL
Nik Akhtar, Shayan (East Carolina University, 2023-11-27)Rho proteins belong to the Ras superfamily of small GTPases. In humans, the Rho family of GTPases contains 20 members out of which the most studied Rho proteins are RhoA, Rac1, and Cdc42. Rho signaling is known to regulate ... -
THE HYALURONAN EXTRACELLULAR MATRIX CRITICALLY REGULATES SYNAPSE FORMATION IN DEVELOPING NEURAL NETWORKS
Wilson, Emily S (East Carolina University, 2021-04-21)The majority of neurodevelopmental disorders present with an imbalance in synaptic signal transmission. The delicate balance of excitatory to inhibitory synaptic transmission is regulated by multiple extracellular and ... -
THE MECHANISTIC TARGET OF RAPAMYCIN (mTOR) AND ITS COMPLEX 1 ASSOCIATED PROTEIN RPTOR ARE GERM CELL-AUTONOMOUSLY REQUIRED FOR SPERMATOGONIAL DEVELOPMENT & CHAPTER IV: INVESTIGATING CHANGES IN THE TESTICULAR TRANSCRIPTOME DURING THE PROSPERMATOGONIAL TRANSITION
Serra, Nicholas (East Carolina University, 2019-07-26)Stem, progenitor, and differentiating spermatogonia are formed in the neonatal mouse testis, and they provide the foundation for spermatogenesis and life-long fertility. Currently, the factors that regulate these varying ... -
THE PRO-INFLAMMATORY ROLE OF G-PROTEIN COUPLED RECEPTOR 4 IN AN ACIDIC MICROENVIRONMENT
Krewson, Elizabeth (East Carolina University, 2018-07-20)The endothelium of the microvascular system serves an ideal mediator between circulating blood and tissues in order to regulate systemic homeostasis. During vascular disease, the normal function and phenotype of endothelial ... -
The Role of Differential Sensitivity to Retinoic Acid (RA) in Regulating Spermatogonial Fate
Velte, Ellen Kay (East Carolina University, 2018-12-10)In the mammalian testis, the foundation of spermatogenesis is provided by spermatogonial stem cells (SSCs); their progeny either remain as stem cells (following a self-renewal division) or proliferate as undifferentiated ... -
THE ROLE OF RETINOIC ACID IN DIRECTING INITIATION OF SPERMATOGENESIS IN THE MOUSE
Busada, Jonathan T. (East Carolina University, 2015-10-23)The basic tenets of gametogenesis are conserved among metazoans. After lineage commitment, germ cells proliferate, complete meiosis, and then differentiate into gametes capable of fertilization. In the mouse, spermatogenesis ... -
THE THERAPEUTIC ROLE OF RHO GTPASES IN TUMORIGENESIS AND CHEMOTHEARPY-INDUCED PERIPHERAL NEUROPATHY
Zhu, Yi (East Carolina University, 2019-07-15)With the advancement of chemotherapy drugs, the general life expectancy of cancer patients has drastically improved. However, persistent side effects, such as chemotherapy-induced peripheral neuropathy (CIPN), often severely ... -
The therapeutic potential of Rho GTPase intervention
Friesland, Amy Michelle (East Carolina University, 2013)Small GTPases of the Rho family are well established regulators of critical cellular functions including cytoskeletal remodeling, motility, vesicle trafficking and cell cycle control. Additionally, aberrant signaling ... -
Tight junction claudin-7 protein modulates multiple processes of cancer progression in human lung cancer cells
Kim, Do Hyung (East Carolina University, 2016-05-03)Carcinogenesis usually consists of cancer initiation, promotion, and progression. Several tight junction claudin proteins have been identified as tumor suppressors or activators during cancer development. As apical proteins, ... -
TIMECOURSE OF SYNAPSE DEVELOPMENT IN HUMAN IPSC-DERIVED NEURONS
Orbita, Adrienne Marie (East Carolina University, 2019-06-12)Understanding the underlying mechanisms in brain formation give an insight to what affects the formation of the brain when affected with autism, specifically, the excitatory and inhibitory synapses. The mechanism of how ...