Browsing by Author "Anderson, Ethan"
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Obesity in a model of haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy
Katunga, Lalage Adalaide; Gudimella, Preeti; Efird, Jimmy T.; Abernathy, Scott; Mattox, Taylor A.; Beatty, Cherese; Darden, Timothy M.; Thayne, Kathleen A.; Alwair, Hazaim; Kypson, Alan P.; Virag, Jitka A. I.; Anderson, Ethan (2015-04)Lipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they have a causal role has remained unclear. Glutathione peroxidase 4 (GPx4) is a selenoenzyme ... -
Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy
Katunga, Lalage A.; Gudimella, Preeti; Efird, Jimmy T.; Abernathy, Scott; Mattox, Taylor A.; Beatty, Cherese; Darden, Timothy M.; Thayne, Kathleen A.; Alwair, Hazaim; Kypson, Alan P.; Virag, Jitka A.; Anderson, Ethan (2015)Objective: Lipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they have a causal role has remained unclear. Glutathione peroxidase 4 (GPx4) is a ... -
Potential for Improved Glycemic Control with Dietary in Patients with Insulin Resistance and Pre-Diabetes
Efird, Jimmy T.; Choi, Yuk Ming; Davies, Stephen W.; Mehra, Sanjay; Anderson, Ethan; Katunga, Lalage Adalaide (2014-02)Bitter Melon (Momordica charantia) is a widely used traditional remedy for hyperglycemia. While the medicinal properties of this plant have been studied extensively using in vitro and animal models, the clinical efficacy ... -
Prohibitin-1 Is a Dynamically Regulated Blood Protein with Cardioprotective Effects in Sepsis
Mattox, Taylor A.; Psaltis, Christine; Robidoux, Jacques; Kilburg-Basnyat, Brita; Gowdy, Kymberly M.; Weihbrecht, Katie; Murphy, Michael P.; Anderson, Ethan (2021) -
Stressing the heart of the matter: Re-thinking the mechanisms underlying therapeutic effects of n-3 polyunsaturated fatty acids
Anderson, Ethan; Taylor, David A. (2012-07-02)Despite their clear therapeutic effects in coronary heart disease, use of n-3 polyunsaturated fatty acids (PUFAs) to treat other types of cardiovascular disease remains controversial, and serious obstacles exist in ... -
Use of monoamine oxidase and redox enzymes in atrial tissue as novel predictors of postoperative atrial fibrillation
Darden, Timothy M. (East Carolina University, 2014)Postoperative atrial fibrillation (POAF) occurs in approximately 30% of cardiac surgery patients. The complication occurs despite advances in surgical procedures. It is associated with increased mortality, morbidity, and ...