Browsing by Author "Biology: Molecular Biology and Biotechnology"
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ESTABLISHING LINKAGE BETWEEN GINS COMPLEX SUB-UNIT Sld5 AND CHECKPOINT PROTEIN Chk2 (loki) USING DROSOPHILA MELANOGASTER AS MODEL ORGANISM
Devadasan, Divya (East Carolina University, 2012)Eukaryotic DNA replication is controlled by a number of proteins that ensures the process takes place accurately. GINS, a hetero-tetrameric protein complex is known to be essential for the initiation and progression of ... -
The Evolution of Organ Shape : Distal Tip Cell Migration and Gonadogenesis in Nematodes
Wyatt, Brent (East Carolina University, 2013)Animals display a variety of shapes in nature. The different shape of homologous organs allows them to adopt different functions and therefore, allows animals to live in different ecological niches. However, little is ... -
EXPLORING THE BYSTANDER EFFECT FOLLOWING VERY LOW DOSE RADIATION
Hollis, Sarah Elizabeth (East Carolina University, 2010)Bystander effects are defined as the phenomenon in which unirradiated cells respond biologically when their neighbors are irradiated. The exact mechanisms of these cellular responses are still not known, especially in ... -
A Functional Analysis of microRNAs in Nicotiana tabacum
Burklew, Caitlin E. (East Carolina University, 2012)MicroRNAs (miRNAs) are a newly discovered class of endogenous post-transcriptional gene regulators that are typically 20-22 nucleotides in length that do not code for proteins. MiRNAs regulate gene expression by either ... -
Hox Gene Expression During Oreochromis niloticus Pharyngeal Arch Development : Discovering the Hox Code
Lyon, Raymond Stewart (East Carolina University, 2010)Hox genes encode transcription factors and have been extensively studied by evolutionary and developmental biologists. Hox genes are responsible for determining specific regional identities along the anterior-posterior and ... -
Identification, Characterization, and Abiotic Stress Analysis of microRNAs in Nicotiana tabacum
Frazier, Taylor Price (East Carolina University, 2010)microRNAs (miRNAs) are non-coding RNAs with short sequences that negatively regulate gene expression at the post-transcriptional levels by either binding to mRNAs for degradation, or by inhibiting protein translation. ... -
Inhibitory and oxidative effects of gossypol on MCF7 Breast Cancer cells in vitro
Winfrey, William Brandon (East Carolina University, 2013)Human cancer is the second leading cause of death in the United States and breast cancer is responsible for the second highest number of deaths in women with cancer worldwide. Today, cancer is becoming more and more ... -
Microbial Carbon Assimilation within the Walls of Deep-sea Hydrothermal Vent Chimneys
Blumenfeld, Heather N. (East Carolina University, 2011)Carbon is one of the most abundant elements on Earth stored in a multitude of reservoirs and constantly cycled through various processes occurring on our planet. Although it represents only a small percentage of the total ... -
Molecular Epidemiology of MRSA Among Patients and Employees in a Surgical Intensive Care Unit
Augustino, Kerri L. (East Carolina University, 2011)Methicillin-resistant Staphylococcus aureus (MRSA) is a pervasive drug resistant human pathogen and has become widespread in hospitals around the world. MRSA infections cause approximately 19,000 deaths among hospitalized ... -
Photofrin-Mediated Electroporation-Assisted Photodynamic Therapy of MCF-7 Human Breast Cancer and B16-F10 Mouse Melanoma Cells
Huffman, David P. (East Carolina University, 2011)Photodynamic therapy is a relatively new player on the field of cancer treatment that involves the injection of a nontoxic light-sensitive drug followed by light excitation, creating reactive oxygen species that cause ... -
Physiological and Phylogenetic Studies of the Biogeography of Alkaliphilic Heterotrophic Bacteria from Serpentinizing Habitats
Kloysuntia, Alyssa N. (East Carolina University, 2014)Serpentinization occurs when ultramafic rocks containing the mineral olivine react with water to produce highly reducing conditions, which are commonly coincident with high concentrations of hydrogen. Hydrogen provides ... -
Physiological Studies of Alkaliphilic Anaerobic Organotrophs in a Serpentinizing Subsurface Habitat
George, Crystal R (East Carolina University, 2014)Microbial habitats in serpentinizing ultramafic rocks represent one of the largest, yet least understood portions of the biosphere, with potentially major consequences for global biogeochemical cycles. Serpentinization is ... -
The Role of eIF4G-1 Isoforms and Live Cell Imaging of IRES-mediated Translation Initiation in Breast Cancer Cells
Crosson, Whitney K. (East Carolina University, 2012)The development of cancer is a consequence of mutations that lead to dysfunctional cell processes such as unrestrained cell proliferation, resistance to apoptosis, and improper regulation of cell processes such as translation. ... -
The Role of Transcription Factors Snail and Slug in Cardiac Myofibroblasts
Ferrell, Paul (East Carolina University, 2014)CCardiac fibrosis is a major facet contributing to cardiac dysfunction following a myocardial infarction. Persistent and excessive collagen deposition via cardiac myofibroblasts is the hallmark of cardiac fibrosis. Cardiac ... -
SPATIAL EXPRESSION OF MATRIX AND MATRIX RECEPTOR PROTEINS IN THE DEVELOPING SYNOVIAL JOINT
Robins, Joshua Eli (East Carolina University, 2013)Little is understood about the complex spatial and temporal molecular interactions necessary to form a fully functional synovial joint. Understanding molecular pathways and signaling within the developing joint continues ... -
Sub-lethal toxic effect of Bisphenol A on Caenorhabditis elegans : the role of stress resistance genes in BPA-induced growth inhibition
Flood, Zailene (East Carolina University, 2014)Endocrine disrupting chemicals (EDCs) have become of concern for a variety of health issues. Bisphenol-A (BPA) is a widely studied EDC and has been characterized by its estrogen-like effects. BPA is a prevalent component ... -
SYNAPTOPODIN-2 ISOFORM A AND D EXPRESSION IN HT-29 HUMAN COLON ADENOCARCINOMA CELLS
Shortt, Kelli A. (East Carolina University, 2013)Synaptopodin-2 is a largely unfolded actin-binding protein that also possesses the characteristics of a hub protein. Synaptopodin-2 has other known binding partners such as filamin and [alpha]-actinin (Weins, et al. 2001 ... -
Targeting aberrant signaling in the EGFR1/HER2/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway : Novel therapeutic interventions in breast cancer
Davis, Nicole Marie (East Carolina University, 2015)Breast cancer is attributed to being the second most deadly cancer in American women. Approximately 1 in 8 women will be diagnosed with breast cancer during her lifetime, and prognosis is dependent upon the genetic make-up ... -
Tumor Growth Induces Oxidative Clustered DNA Lesions Damage in Distant Mouse Tissue in vivo
Kryston, Thomas (East Carolina University, 2010)Our goal was to ascertain if DNA damage induced by oxidative stress is capable of being exploited as a precancerous or cancer biomarker. The specific DNA damage that we assessed was oxidatively induced non-DSB clustered ... -
USING LASER CAPTURE MICRODISSECTION (LCM) TO EXAMINE MADS-BOX GENE EXPRESSION IN THE UPPER AND LOWER FLORAL MERISTEMS OF MAIZE
Nukunya, Kate Adriana (East Carolina University, 2013)MADS-box transcription factors are important regulators of flower development in all flowering plants. In the grasses, flowers (called florets) are contained in spikelets. Maize spikelets contain two florets (the upper and ...