Browsing by Author "McClung, Joseph M."
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Mitochondrial Dysfunction in HIV-1 Transgenic Mouse Cardiac Myocytes
McClung, Joseph M. (2019-09-07) -
The Multifunctional Protein BAG3: A Novel Therapeutic Target in Cardiovascular Disease
Myers, Valerie D.; McClung, Joseph M.; Wang, JuFang; Tahrir, Farzaneh G.; Gupta, Manish K.; Gordon, Jennifer; Kontos, Christopher H.; Khalili, Kamel; Cheung, Joseph Y.; Feldman, Arthur M. (2018-02-26)The B-cell lymphoma 2–associated anthanogene (BAG3) protein is expressed most prominently in the heart, the skeletal muscle, and in many forms of cancer. In the heart, it serves as a co-chaperone with heat shock proteins ... -
Muscle cell derived angiopoietin-1 contributes to both myogenesis and angiogenesis in the ischemic environment
McClung, Joseph M.; Reinardy, Jessica L.; Mueller, Sarah B.; McCord, Timothy J.; Kontos, Christopher D.; Brown, David A.; Hussain, Sabah N. A.; Schmidt, Cameron A.; Ryan, Terence E.; Green, Thomas D. (2015-05)Recent strategies to treat peripheral arterial disease (PAD) have focused on stem cell based therapies, which are believed to result in local secretion of vascular growth factors. Little is known, however, about the role ... -
PFKFB3-Mediated Glycolysis Rescues Myopathic Outcomes in the Ischemic Limb
McClung, Joseph M.; Ryan, Terence E.; Spangenburg, Espen E.; Schmidt, Cameron A.; Tarpey, Michael D.; Amorese, Adam J.; Yamaguchi, Dean J.; Goldberg, Emma J.; Iñigo, Melissa M.R.; Karnekar, Reema; Brophy, Patricia; Green, Thomas D.; Neufer, P. Darrell; Fisher-Wellman, Kelsey H.; Spangenburg, Espen E. (2020-09-17) -
PFKFB3-Mediated Glycolysis Rescues Myopathic Outcomes in the Ischemic Limb
Spangenburg, Espen; Ryan, Terence E.; McClung, Joseph M. (2020-09-17) -
Physiologic Determinants of Ischemic Skeletal Muscle Pathophysiology
Schmidt, Cameron Alan (East Carolina University, 2018-11-29)Lower limb peripheral arterial occlusive disease (PAD) has major impacts on patient quality of life and, in its most severe form, carries a significant risk of mortality. The canonical approach to PAD research has been ... -
Racial Differences in the Limb Skeletal Muscle Transcriptional Programs of Patients with Critical Limb Ischemia
Terwilliger, Zoe S.; Goldberg, Emma J.; Schmidt, Cameron A.; Karnekar, Reema; Brophy, Patricia; Green, Thomas D.; Zeczycki, Tonya N.; McClung, Joseph M.; Ryan, Terence E.; Yamaguchi, Dean J.; Gabhann, Feilim Mac; Annex, Brian H. (2021-06) -
Subcellular Proteomics Combined with Bioenergetic Phenotyping Reveals Protein Biomarkers of Respiratory Insufficiency in the Setting of Proofreading-Deficient Mitochondrial Polymerase
McClung, Joseph M.; McLaughlin, Kelsey L.; Kew, Kimberly A.; Fisher-Wellman, Kelsey H. (2020-02-27) -
Targeted Expression of Catalase to Mitochondria Protects Against Ischemic Myopathy in High-Fat Diet-Fed Mice
Spangenburg, Espen; Ryan, Terence E.; Schmidt, Cameron A.; Green, Thomas D.; Neufer, P. Darrell; McClung, Joseph M. (2016-06-09) -
Temporal Association Between Ischemic Muscle Perfusion Recovery and the Restoration of Muscle Contractile Function After Hindlimb Ischemia
Goldberg, Emma J.; Schmidt, Cameron A.; Green, T. D.; Karnekar, R.; Yamaguch, D. J.; Spangenberg, E. E.; McClung, Joseph M. (2019-06-28)During incomplete skeletal muscle recovery from ischemia, such as that occurs with critical limb ischemia, the temporal relationship between recovery of muscle capillary perfusion and contractile function is poorly defined. ... -
Temporal Association Between Ischemic Muscle Perfusion Recovery and the Restoration of Muscle Contractile Function After Hindlimb Ischemia
McClung, Joseph M.; Goldberg, Emma J.; Schmidt, Cameron A.; Green, T. D.; Karnekar, R.; Yamaguchi, D. J.; Spangenburg, E. E. (2019-06-28) -
Tissue-Specific Characterization of Mitochondrial Branched-Chain Keto Acid Oxidation Using a Multiplexed Assay Platform
McClung, Joseph M. (2019-05-31)