Browsing by Author "McCubrey, James A."
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Computational identification of microRNAs associated to both epithelial to mesenchymal transition and NGAL/MMP-9 pathways in bladder cancer
Falzone, Luca; Candido, Saverio; Salemi, Rossella; Basile, Maria S.; Scalisi, Aurora; McCubrey, James A.; Torino, Francesco; Signorelli, Salvatore S.; Montella, Maurizio; Libra, Massimo (2016-11-08)Bladder cancer is one of the leading cancer of the urinary tract. It is often diagnosed at advanced stage of the disease. To date, no specific and effective early detection biomarkers are available. Cancer development and ... -
Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer
Pappalardo, Francesco; Russo, Giulia; Candido, Saverio; Pennisi, Marzio; Cavalieri, Salvatore; Motta, Santo; McCubrey, James A.; Nicoletti, Ferdinando; Libra, Massimo (2016-03)Background Malignant melanoma is an aggressive tumor of the skin and seems to be resistant to current therapeutic approaches. Melanocytic transformation is thought to occur by sequential accumulation of genetic and ... -
Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer
Pappalardo, Francesco; Russo, Giulia; Candido, Saverio; Pennisi, Marzio; Cavalieri, Salvatore; Motta, Santo; McCubrey, James A.; Nicoletti, Ferdinando; Libra, Massimo (2016-03-25)Background Malignant melanoma is an aggressive tumor of the skin and seems to be resistant to current therapeutic approaches. Melanocytic transformation is thought to occur by sequential accu- mulation of genetic and ... -
Computational Modeling of PI3K/AKT and MAPK Signaling Pathways in Melanoma Cancer
McCubrey, James A. (2016-03-25) -
Cooperative Effects of Akt-1 and Raf-1 on the Induction of Cellular Senescence in Doxorubicin or Tamoxifen Treated Breast Cancer Cells
Taylor, Jackson R.; Lehmann, Brian D.; Chappell, William H.; Abrams, Stephen L.; Steelman, Linda S.; McCubrey, James A. (2011-08)Escape from cellular senescence induction is a potent mechanism for chemoresistance. Cellular senescence can be induced in breast cancer cell lines by the removal of estrogen signaling with tamoxifen or by the accumulation ... -
Cytotoxic Activity of the Novel Small Molecule AKT Inhibitor SC66 in Hepatocellular Carcinoma Cells
McCubrey, James A. (2015-01-30) -
Cytotoxic Activity of the Novel Small Molecule AKT Inhibitor SC66 in Hepatocellular Carcinoma Cells
McCubrey, James A. (2015) -
Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells
Cusimano, Antonella; Puleio, Roberto; D'Alessandro, Natale; Loria, Guido R.; McCubrey, James A.; Montalto, Giuseppe; Cervello, Melchiorre (2015-01)Hepatocellular carcinoma (HCC) is characterized by limited response to current drug therapies. Here, we report that SC66, a novel AKT inhibitor, reduced cell viability in a dose- and time-dependent manner, inhibited colony ... -
Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells
Cusimano, Antonella; Puleio, Roberto; D'Alessandro, Natale; Loria, Guido R.; McCubrey, James A.; Montalto, Giuseppe; Cervello, Melchiorre (2014)Hepatocellular carcinoma (HCC) is characterized by limited response to current drug therapies. Here, we report that SC66, a novel AKT inhibitor, reduced cell viability in a dose- and time-dependent manner, inhibited ... -
Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention
Davis, Nicole Marie; Sokolosky, Melissa; Stadelman, Kristin; Abrams, Stephen L.; Libra, Massimo; Candido, Saverio; Nicoletti, Ferdinando; Polesel, Jerry; Maestro, Roberta; D'Assoro, Antonino B.; Drobot, Lyudmyla B.; Rakus, Dariusz; Gizak, Agnieszka; Laidler, Piotr; Dulińska-Litewka, Joanna; Basecke, Jorg; Mijatovic, Sanja; Maksimovic-Ivanic, Danijela; Montalto, Giuseppe; Cervello, Melchiorre; Fitzgerald, Timothy L.; Demidenko, Zoya N.; Martelli, Alberto M.; Cocco, Lucio; Steelman, Linda S.; McCubrey, James A. (2014-7) -
Dimeric and tetrameric forms of muscle fructose-1,6- bisphosphatase play different roles in the cell
Wiśniewski, Janusz; Piróg, Michał; Hołubowicz, Rafał; Dobryszycki, Piotr; McCubrey, James A.; Rakus, Dariusz; Gizak, Agnieszka (2017-12-15)Muscle fructose 1,6-bisphosphatase (FBP2), besides being a regulatory enzyme of glyconeogenesis also protects mitochondria against calcium stress and plays a key role in regulation of the cell cycle, promoting cardiomyocytes ... -
Dimeric and tetrameric forms of muscle fructose-1,6-bisphosphatase play different roles in the cell
McCubrey, James A. (2017-12-15) -
Drug-resistance in doxorubicin-resistant FL5.12 hematopoietic cells: elevated MDR1, drug efflux and side-population positive and decreased BCL2-family member expression
Steelman, Linda S.; Abrams, Stephen L.; Ruvolo, Peter; Ruvolo, Vivian; Cocco, Lucio; Ratti, Stefano; Martelli, Alberto M.; Neri, Luca M.; Candido, Saverio; Libra, Massimo; McCubrey, James A. (2017-12-06)Chemotherapeutic drug treatment can result in the emergence of drug-resistant cells. By culturing an interleukin-3 (IL-3)-dependent cell line, FL5.12 cells in the presence of the chemotherapeutic drug doxorubicin, we ... -
Effects of Ectopic Expression of NGAL on Doxorubicin Sensitivity
Chappell, William H.; Abrams, Stephen L.; Montalto, Giuseppe; Cervello, Melchiorre; Martelli, Alberto M.; Candido, Saverio; Libra, Massimo; Polesel, Jerry; Talamini, Renato; Arlinghaus, Ralph; Steelman, Linda S.; McCubrey, James A. (2012-10)Neutrophil gelatinase-associated lipocalin (NGAL, a.k.a Lnc2) is a member of the lipocalin family which has diverse roles including stabilizing matrix metalloproteinase-9 from auto-degradation and as siderocalins which are ... -
Effects of ectopic expression of NGAL on doxorubicin sensitivity
Chappell, William H.; Abrams, Stephen L.; Montalto, Giuseppe; Cervello, Melchiorre; Martelli, Alberto M.; Candido, Saverio; Libra, Massimo; Polesel, Jerry; Talamini, Renato; Arlinghaus, Ralph; Steelman, Linda S.; McCubrey, James A. (2012-10-20)Neutrophil gelatinase-associated lipocalin (NGAL, a.k.a Lnc2) is a member of the lipocalin family which has diverse roles including stabilizing matrix metalloproteinase-9 from auto-degradation and as siderocalins which are ... -
Effects of the Mutant TP53 Reactivator APR-246 on Therapeutic Sensitivity of Pancreatic Cancer Cells in the Presence and Absence of WT-TP53
Abrams, Stephen L.; Akula, Shaw M.; Steelman, Linda S.; McCubrey, James A. (2022-02-24) -
The Emerging Role of the Phosphatidylinositol 3-Kinase/ Akt/Mammalian Target of Rapamycin Signaling Network in Cancer Stem Cell Biology
Martelli, Alberto M.; Evangelisti, Camilla; Chiarini, Francesca; Grimaldi, Cecilia; McCubrey, James A. (2010-08)The cancer stem cell theory entails the existence of a hierarchically organized, rare population of cells which are responsible for tumor initiation, self-renewal/maintenance, and mutation accumulation. The cancer stem ...