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Now showing items 2217-2236 of 10629
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Cytokine-Neuroantigen Fusion Proteins as a New Class of Tolerogenic, Therapeutic Vaccines for Treatment of Inflammatory Demyelinating Disease in Rodent Models of Multiple Sclerosis
(2012-08)Myelin-specific induction of tolerance represents a promising means to modify the course of autoimmune inflammatory demyelinating diseases such as multiple sclerosis (MS). Our laboratory has focused on a novel preclinical ... -
Cytokines and neuroantigens for treatment of immune disorders
(2017-05-10)The present invention provides methods of regulating an immunological disorder comprising administering to a subject an effective amount of (i) an autoimmune antigen in conjunction with (ii) an anti-inflammatory cytokine. ... -
Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells
(2015-01)Hepatocellular carcinoma (HCC) is characterized by limited response to current drug therapies. Here, we report that SC66, a novel AKT inhibitor, reduced cell viability in a dose- and time-dependent manner, inhibited colony ... -
Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells
(2014)Hepatocellular carcinoma (HCC) is characterized by limited response to current drug therapies. Here, we report that SC66, a novel AKT inhibitor, reduced cell viability in a dose- and time-dependent manner, inhibited ... -
Cytotoxic and Pathogenic Properties of Klebsiella oxytoca Isolated from Laboratory Animals
(2014-07)Klebsiella oxytoca is an opportunistic pathogen implicated in various clinical diseases in animals and humans. Studies suggest that in humans K. oxytoca exerts its pathogenicity in part through a cytotoxin. However, cytotoxin ... -
Daily and season-long fantasy sports participation and gambling-related problems among a sample of college students at three universities
(2018)Traditionally, fantasy sports have been played in season-long leagues, but recently daily fantasy sports (DFS) have emerged, allowing participants to play fantasy contests over shorter periods of time. Although participating ... -
Daily precipitation distributions over the intra-Americas sea and their interannual variability
(2012-05-30)The seasonal (March to October) and interannual variability of the cumulative distribution function (CDF) of precipitation is examined for Meso-America, the eastern Pacific and western Atlantic, commonly referred to as the ... -
Daily walks can improve digestion, chronic conditions
(2023-09-13)This is a weekly Q and A newspaper column under the byline of Dr. Kathy Kolasa. Today's column is "Daily walks can improve digestion, chronic conditions." -
Damage control surgery: It's evolution over the last 20 years
(2012-03-15)In less than twenty years, what began as a concept for the treatment of exsanguinating truncal trauma patients has become the primary treatment model for numerous emergent, life threatening surgical conditions incapable ... -
The Dangers of Online Shopping
(2022-04-19)Online shopping has become a crucial part of society in today’s age of technology. Many of us face identity theft, credit card theft, and more just by putting our personal information on shopping websites. Downloading ... -
Dare County Quality Improvement Project for the Overweight and Obese Adult Patient
(2019-04-15)Obesity is a serious disease that has tripled in prevalence since the 1980s, it affects all Americans either directly or indirectly, and attributes to several serious comorbidities and premature death. While guidelines do ... -
"DARKNESS, DIRT, DEVIANCE"--AND DADDY : PATRILINEAL RELATIONSHIPS AND THE NEGOTIATION OF WOMANHOOD IN THE LITERATURE OF MIDDLE EASTERN AND ARAB-AMERICAN WOMEN
(East Carolina University, 2015)This thesis explores both works of fiction and non-fiction through which several Middle Eastern and Arab-American women writers have rebelled against traditional religious and ethical standards of their cultures in order ... -
Darth Bane : The Monomyth's Dark Liberator
(East Carolina University, 2013)Darth Bane: The Monomyth's Dark Liberator is an original thesis based on Joseph Campbell's theory of the monomyth and Drew Karpyshyn's Darth Bane Trilogy. Campbell's theory of the monomyth has most commonly been called the ... -
“DASH AT THE ENEMY!”: THE USE OF MODERN NAVAL THEORY TO EXAMINE THE BATTLEFIELD AT ELIZABETH CITY, NORTH CAROLINA
(East Carolina University, 2016-01-15)Immediately following the Union victory at Roanoke Island (7-8 February 1862), Federal naval forces advanced north to the Pasquotank River and the town of Elizabeth City, North Carolina where remnants of the Confederate ...