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The Development of Confederate Ship Construction : An Archaeological and Historical Investigation of Confederate Ironclads Neuse and Jackson
(East Carolina University, 2009)Southern shipbuilding in 1861 was comparable to construction throughout the United States. Confederate ships early in the war show continuity of these traditions, but beginning in 1862, wartime stimuli created a distinct ... -
Development of Engaging Whiteboard Videos to Support Head Start Teachers’ Understanding of Evidence-based Strategies for Teaching Preschool Children (3-5 years) Science in the Context of Healthy Eating
(East Carolina University, 2023-12-07)Learning Objective: Identify Head Start teachers’ and relevant professionals’ perceptions of whiteboard videos designed to support understanding evidence-based strategies for teaching preschool children (3-5 years) science ... -
Development of Fed and Starved Striped Bass (Morone saxatilis) Larvae from the Roanoke River, North Carolina
(East Carolina University, 1986-07)Fed and unfed striped bass larvae were reared in a laboratory using ambient Roanoke River water to determine differences in growth and development. These differences were used to histologically determine the nutritional ... -
Development of Green Subcritical Water Separation Technology
(East Carolina University, 2019-08-19)Theoretically speaking, water under temperature and pressure conditions below its critical point is called subcritical water. However, the term “subcritical water” normally refers to hot water up to 374 C and pressure up ... -
Development of improved therapeutic mesothelin-based vaccines for pancreatic cancer
(2018-02-23)Pancreatic cancer is the 5th leading cause of cancer deaths, and there are no effective treatments. We developed a poxvirus platform vaccine with improved immunogenicity and inserted the mesothelin gene to create an ... -
DEVELOPMENT OF INTERPROFESSIONAL COMPETENCIES FOLLOWING A SIMULATED HOME VISIT: A QUALITATIVE STUDY OF STUDENTS’ WRITTEN REFLECTIONS
(East Carolina University, 2022-05-05)Background: Simulated learning can prepare interprofessional student teams for collaborative clinical practice through the demonstration of skills and competencies in a realistic, controlled clinical setting. The home as ... -
Development of NMR Methodologies to Study Site Specific Zinc-Protein Interactions
(East Carolina University, 2021-07-26)Found in all three biological domains of life and the second most abundant metal in the human body, zinc (Zn2+) is essential to various cellular processes like the metabolism of DNA and RNA, gene expression, and the ... -
DEVELOPMENT OF SMALL-MODELCULE INHIGITORS OF THE INTIATING PROTEASES, C1r AND C1s, OF THE CLASSICAL COMPLEMENT PATHWAY
(2019-12)Complement is a proteolytic cascade that upon activation plays a key effector role in the innate immune system and acts to prime the adaptive immune response. During normal homeostatic events, complement is tightly regulated ... -
Development of small-molecule inhibitors of the initiating proteases, C1r and C1s, of the classical complement pathway
(East Carolina University, 2019-12-12)Complement is a proteolytic cascade that upon activation plays a key effector role in the innate immune system and acts to prime the adaptive immune response. During normal homeostatic events, complement is tightly regulated ... -
Development of the ECU Behavioral and Lifestyle Risk Factor Assessment in Cardiology
(East Carolina University, 2021-12-08)Background: Atrial fibrillation (AF) occurs when rapid and disorganized electrical signals cause the atria in the heart to irregularly beat, not allowing blood to effectively flow from the atria to the ventricles. Over ... -
Development of the Peripartum Cardiomyopathy Quality Of Life Registry
(East Carolina University, 2016-07-08)Peripartum cardiomyopathy (PPCM) is a relatively rare form of heart failure that develops in young women in the third trimester of pregnancy or during the postpartum period. Despite its potentially devastating impact on ... -
Development of the Special Olympics North Carolina MedFest Toolkit
(2020-04-19)[BACKGROUND] Limited access to quality healthcare for individuals living with an intellectual disability (ILID) has numerous implications, including poorer health outcomes and significant health disparities for the ... -
DEVELOPMENT OF UNNATURAL SUBSTRATES AND TRYPTOPHAN AMINO ACIDS TO STUDY PROTON COUPLED ELECTRON TRANSFER IN ENZYMES
(East Carolina University, 2020-12-09)Proton-coupled electron transfer plays an important role in substrate oxidation by C-H bond cleavage and long-range pathways associated with bioenergetics. This thesis is focused on the synthesis of unnatural substrates ... -
Development of Walk Tests to Estimate Aerobic Fitness in 10 to 13 Year-Old Children
(East Carolina University, 2013)Aerobic fitness is an important indicator of health for children. Estimation of aerobic fitness (VO₂[subscript]max) from field-based tests is an essential aspect of youth fitness tests. Field tests can also provide researchers ... -
Developmental Implications of Youth Sport Participation on Physical Activity and Sport Participation in Young Adulthood
(East Carolina University, 2017-12-14)This study sought to address a point of controversy within youth sports: whether young athletes should specialize early (e.g., Ericsson, Krampe & Tesch-Römer, 1993) or if it is favorable to follow the path of early ... -
Developmental lead exposure and the exacerbation of Alzheimer's pathology: an immunological analysis
(East Carolina University, 2014)Early neuroimmune dysfunction may play a driving role in the etiopathology of Alzheimer's disease (AD), stemming from the hypothesis that many late-stage adult diseases have an early-life basis. Here we explore whether ...