Browsing by Title
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The Role of Transcription Factors Snail and Slug in Cardiac Myofibroblasts
(East Carolina University, 2014)CCardiac fibrosis is a major facet contributing to cardiac dysfunction following a myocardial infarction. Persistent and excessive collagen deposition via cardiac myofibroblasts is the hallmark of cardiac fibrosis. Cardiac ... -
Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer
(2014-03)Cancer remains one of the major cause of death in the Western world. Although, it has been demonstrated that new therapies can improve the outcome of cancer patients, still many patients relapse after treatment. Therefore, ... -
Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
(2011-03)Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation ... -
Roles of the RAF/MEK/ERK Pathway in Cell Growth, Malignant Transformation and Drug Resistance
(East Carolina University, 2007-08)Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit signals from their receptors to regulate gene expression and prevent apoptosis. Some components of these pathways are mutated or aberrantly ... -
Romancing The Labor
(East Carolina University, 2013)This is a report of a creative body of work dealing with the adaptation of traditional industrial processes into contemporary sculpture. This thesis shows that admiration for labor is still present in sculpture by utilizing ... -
Rooftop Gardens and Solar Energy
(2016-04)Green roofs are a form of green architecture used to provide a natural insulation for a residential or commercial building. The green roof replaces the traditional roofing shingles. The roof is composed of soil and vegetation. ... -
Root parasitic plant and shoot parasitic plant obtained Brassicaceae-specific genes by horizontal gene transfer
(2014)Background Besides gene duplication and de novo gene generation, horizontal gene transfer (HGT) is another important way of acquiring new genes. HGT may endow the recipients with novel phenotypic traits that are important ... -
Rosie the Riveter and the Kitchen Soldier : Fighting the Second World War from Wilmington, North Carolina
(East Carolina University, 2015)The purpose of this thesis is to examine whether or not traditional gender norms remained standing at the conclusion of World War II in Wilmington, North Carolina. This topic would have been impossible to cover on a ... -
Roxie, Mr. Bingo, Kewl and The Gate : Street Gangs in Kinston: Participating in One City's Game of Chance to Save Itself
(East Carolina University, 2010)This project in pursuit of social and aesthetic experience involved the Kinston Community Council for the Arts, the Kinston Department of Public Safety and The Gate of Kinston (Gang Awareness Training and Education; a ... -
Ruff Sketches: The Art of Phoebe Sullivan
(2015)As an artist and illustrator, Phoebe Sullivan is inspired by films, books, and nature. Her ideas begin in her sketchbook. She loves to bring entertaining and meaningful stories to life and has a drive for learning and ... -
Rules of (employee) engagement: A comprehensive model
(East Carolina University, 2016-12-15)The purpose of the study was to examine a comprehensive model of employee engagement that included a diverse set of (1) personal factors, (2) environmental factors, (3) job attitudes, (4) work outcomes and (5) health ... -
Rules of thumb for deselecting, relocating, and retaining bound journals
(2012)Purpose – Like many other academic libraries, Joyner Library at East Carolina University has experienced pressure in recent years to convert stacks space to other uses. The rise of electronic collections coupled with the ... -
Runtime Monitoring On Hard Real-Time Operating Systems
(East Carolina University, 2015)This thesis will compare and evaluate different approaches in integrating runtime monitors into processes running on a hard real-time operating system. The host system is a single board computer (SBC) with a VxWorks 653 ... -
The RXR-alpha C-terminus T462 is a NMR sensor for coactivator peptide binding
(East Carolina University, 2008-02-22)The C-terminal activation function-2 (AF-2) helix plays a crucial role in retinoid X receptor alpha (RXRα)-mediated gene expression. Here, we report a nuclear magnetic resonance (NMR) study of the RXRα ligand-binding domain ... -
S.O.S.
(2012-12)The concept that type 2 diabetes mellitus (T2DM) can be reversed with an intestinal operation is counterintuitive. How could our costliest disease be forced into full, durable, and safe remission with the bypass of a few ... -
Safe design of skyrise greenery in Singapore
(2012)Singapore is transforming from a “garden city” to a “City-in-a-Garden”. Designing for safety is recognized by researchers and some governments as a best practice in facilitating eventual worker safety within the built ... -
Safe Design Suggestions for Vegetated Roofs
(2012-08)Rooftop vegetation is becoming increasingly popular because of its environmental benefits and its ability to earn green-building certification credits. With the exception of one international guideline, there is little ... -
Safety lockout adapter and coupling member used therefor
(1992-12-01)A safety lockout adapter is formed of two coupling members. Each coupling member is adapted to couple with another corresponding coupling member of substantially similar configuration for locking-out power disconnects or ... -
SALINITY DISTRIBUTION IN A CHANNELIZED WETLAND AT EMILY AND RICHARDSON PREYER BUCKRIDGE COASTAL RESERVE, TYRRELL COUNTY, NORTH CAROLINA
(East Carolina University, 2014)The Emily and Richardson Preyer Buckridge Coastal Reserve is a low-lying, peatland-dominated freshwater wetland located in the southern Albemarle Estuarine System. The construction of an extensive canal network that ... -
The Same Green and the Same Square and Other Stories
(East Carolina University, 2013)"The Same Green and The Same Square and Other Stories" is a collection of seven short stories that explore the "Why?" of human behavior and emotions--why we do the things we do, why we think the things we think, why we ...