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Now showing items 3166-3185 of 10629
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Elevated Endogenous Erythropoietin Concentrations Are Associated with Increased Risk of Brain Damage in Extremely Preterm Neonates
(2015-03-20)Background We sought to determine, in very preterm infants, whether elevated perinatal erythropoietin (EPO) concentrations are associated with increased risks of indicators of brain damage, and whether this risk differs ... -
Elevated Endogenous Erythropoietin Concentrations Are Associated with Increased Risk of Brain Damage in Extremely Preterm Neonates
(2015-03)Background We sought to determine, in very preterm infants, whether elevated perinatal erythropoietin (EPO) concentrations are associated with increased risks of indicators of brain damage, and whether this risk differs ... -
Eliminating Barriers to Youth Sport in Pitt County
(East Carolina University, 2021-04-23)This case study provides an opportunity for students to better understand barriers faced by low-income families participating in local sport opportunities and then offer creative solutions in an attempt to alleviate some ... -
Elizabeth I, Visual Icon : A Title Unintended
(East Carolina University, 2014)This thesis explores Elizabeth I's relationship with her official state portraiture to show that she placed little value in its meaning and authority for political and diplomatic uses. Understanding her personal relationship ... -
Elucidating "Consumption" : Using Fluorescent Steroid Probes to Understand Host Cholesterol Utilization by Mycobacterium spp.
(East Carolina University, 2014)Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) disease, is the leading cause of death due to bacterial infection worldwide, claiming nearly two million lives each year. Often, the immune system ... -
Elucidating Gene Function with the use of Genome Wide Association Study (GWAS)
(East Carolina University, 2015)DNA replication and cell proliferation are intensely studied subjects. There have been countless experiments and hours put into better understanding how DNA is replicated and compacted, and how cells are able to proliferate ... -
Elucidating the Mechanism of Action of Unnatural Amino Acid Containing Antimicrobial Peptides in Membrane Environments
(East Carolina University, 2012)Organism resistance continues to develop to the currently available antimicrobial compounds necessitating the development of innovative new therapeutic compounds with different specificities and mechanisms of action that ... -
Elucidating the mechanisms of Nickel as an animal mutagen
(East Carolina University, 2016-04-28)Nickel is an essential metal for many organisms. Nickel occurs naturally from volcanism and weathering of stone. Recently production of nickel from anthropogenic sources has overtaken natural production. Combustion of ... -
Elucidating the Mechanisms of Transthyretin Aggregation in Transthyretin Amyloidosis
(East Carolina University, 2018-07-24)Accumulation of insoluble aggregates (amyloids) is a characteristic feature of many neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. Aggregation and deposition of Transthyretin (TTR) protein ... -
Elucidating the Role of BRCA1 in Skeletal Muscle Myogenesis and Function
(East Carolina University, 2021-04-23)The breast cancer 1 early onset gene (BRCA1) is a tumor suppressor gene susceptible to mutations associated with cancer development. We have identified that the BRCA1 gene is expressed in skeletal muscle and plays a critical ... -
ELUCIDATION OF 15-LIPOXYGENASE-2 AND PEBP1 INTERACTIONS IMPLICATED IN ACUTE RENAL FAILURE
(East Carolina University, 2019-05-14)15-Lipoxygenase-2 (15-LOX-2) is one of six human lipoxygenase enzymes that catalyze the peroxidation of fatty acids and are involved in many different cell signaling pathways related to development, homeostasis, and even ... -
Elucidation of allosteric behavior and enzyme-effector complexes of human 15-lipoxygenase-2 through hydrogen-detuerium exchange mass spectrometry
(East Carolina University, 2019-05-03)The enzymatic activity of human 15-lipoxygenase-2 (15-LOX-2) has been implicated in human inflammatory diseases such as atherosclerotic cardiovascular disease and plays an important role in maintaining homeostasis. 15-LOX-2 ... -
ELUCIDATION ON THE MECHANISM OF CAMKKα AS A PRO-GROWTH KINASE IN MOUSE SKELETAL MUSCLE
(East Carolina University, 2016-12-15)Type 2 diabetes affects ~25 million people in the U.S., and is the primary cause of non-traumatic lower limb amputation and the leading cause of blindness in adults. Major risk factors for the development of type 2 diabetes ... -
Elusive left ventricular thrombus: Diagnostic role of cardiac magnetic resonance imaging-A case report and review of the literature
(2018-06-16)Identification of left ventricular mural thrombus (LVT) may be challenging depending on the imaging modality used. We present a case of LVT which was incidentally identified on cine cardiac magnetic resonance imaging (CMR). ...