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Increased Coronary Artery Disease Severity in Black Women Undergoing Coronary Bypass Surgery
(2015)Race and sex disparities are believed to play an important role in heart disease. The purpose of this study was to examine the association between race, sex, and number of diseased vessels at the time of coronary artery ... -
Increased Coronary Artery Disease Severity in Black Women Undergoing Coronary Bypass Surgery
(2015-02)Race and sex disparities are believed to play an important role in heart disease. The purpose of this study was to examine the association between race, sex, and number of diseased vessels at the time of coronary artery ... -
Increased Degradation of Adenosine Monophosphate as a Regulator of Maximal Mitochondrial Respiration
(East Carolina University, 2019-07-02)Atrophied skeletal muscle have enhanced fatigability due at least in part to a reduction of mitochondria content. Mitochondrial biogenesis is regulated by the transcriptional coactivator PGC-1 alpha, which in turn is ... -
Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains
(East Carolina University, 2009-02-25)Mutations in the DJ-1 gene have been linked to autosomal recessive familial Parkinson's disease. To understand the function of DJ-1, we determined the DJ-1 expression in both zebrafish and post mortem human brains. We found ... -
Increased Glycemic Variability Is Independently Associated With Length of Stay and Mortality in Noncritically Ill Hospitalized Patients
(2013-12)OBJECTIVE To investigate the association between glycemic variability (GV) and both length of stay (LOS) and 90-day mortality in noncritically ill hospitalized patients. RESEARCH DESIGN AND METHODS This study retrospectively ... -
Increased Long-Term Mortality among Black CABG Patients Receiving Preoperative Inotropic Agents
(2015-07)The aim of this study was to examine racial differences in long-term mortality after coronary artery bypass grafting (CABG), stratified by preoperative use of inotropic agents. Black and white patients who required ... -
Increased Long-Term Mortality among Black CABG Patients Receiving Preoperative Inotropic Agents
(2015-07)The aim of this study was to examine racial differences in long-term mortality after coronary artery bypass grafting (CABG), stratified by preoperative use of inotropic agents. Black and white patients who required ... -
Increased mitochondrial NADPH oxidase 4 (NOX4) expression in aging is a causative factor in aortic stiffening
(2019-08-02)Aging is characterized by increased aortic stiffness, an early, independent predictor and cause of cardiovascular disease. Oxidative stress from excess reactive oxygen species (ROS) production increases with age. Mitochondria ... -
Increased Nonconducted P-Wave Arrhythmias after a Single Oil Fly Ash Inhalation Exposure in Hypertensive Rats
(East Carolina University, 2009-05)Background: Exposure to combustion-derived fine particulate matter (PM) is associated with increased cardiovascular morbidity and mortality especially in individuals with cardiovascular disease, including hypertension. PM ... -
Increased nucleotide polymorphic changes in the 5'-untranslated region of δ-catenin (CTNND2) gene in prostate cancer
(East Carolina University, 2009-01)Cancer pathogenesis involves multiple genetic and epigenetic alterations, which result in oncogenic changes in gene expression. δ-Catenin (CTNND2) is overexpressed in cancer although the mechanisms of its upregulation are ... -
Increased Secretion and Expression of Myostatin in Skeletal Muscle From Extremely Obese Women
(East Carolina University, 2009-01)OBJECTIVE- Obesity is associated with endocrine abnormalities that predict the progression of insulin resistance to type 2 diabetes. Because skeletal muscle has been shown to secrete proteins that could be used as biomarkers, ... -
Increased Systemic Th17 Cytokines Are Associated with Diastolic Dysfunction in Children and Adolescents with Diabetic Ketoacidosis
(2013-08-27)Diastolic dysfunction suggestive of diabetic cardiomyopathy is established in children with T1DM, but its pathogenesis is not well understood. We studied the relationships of systemic inflammatory cytokines/chemokines and ... -
Increased Systemic Th17 Cytokines Are Associated with Diastolic Dysfunction in Children and Adolescents with Diabetic Ketoacidosis
(2013)Diastolic dysfunction suggestive of diabetic cardiomyopathy is established in children with T1DM, but its pathogenesis is not well understood. We studied the relationships of systemic inflammatory cytokines/chemokines and ... -
Increased TNF-alpha and sTNFR2 levels are associated with high-grade anal squamous intraepithelial lesions in HIV-positive patients with low CD4 level
(2017-12-01)Compared with HIV-negative individuals, HIV-positive individuals have a higher prevalence of anogenital human papillomavirus (HPV) infection, the causative agent of anogenital cancer. TNF-alpha is a major proinflammatory ... -
Increasing Advance Care Planning in Primary Care
(2023-07-10)Advance Care Planning (ACP) discusses and documents end-of-life healthcare wishes with a medical provider. Having a documented ACP has been shown to decrease Medicare spending while increasing patient quality of life and ... -
INCREASING AFRICAN AMERICAN ADVANCED STEM PROFESSIONALS: A CASE STUDY OF TWO PREDOMINANTLY WHITE FLAGSHIP UNIVERSITIES IN THE SOUTH
(East Carolina University, 2018-04-23)This qualitative multiple-case study explores how two select predominantly white institutions (PWIs) have learned to be successful in advancing undergraduate African-American students to advanced degrees in the life sciences. ... -
Increasing Alcohol Screening Among Women
(2020-04-24)Alcohol use disorder (AUD) is occurring at increasing rates among women in the United States. High-risk drinking, heavy alcohol use, and binge drinking are characteristics of the disorder. Screening for alcohol use can ... -
Increasing Awareness of Cardiovascular Risks that Impact Black Men through Barbershop Conversation
(2024-04-18)Black men have suffered abuse and mistreatment within our healthcare system. Past events proliferated medical mistrust and created a separation between provider and patient. As a result, many individuals within the Black ...