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Now showing items 5471-5490 of 10629
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Investigation of the Zinc binding region of Prothymosin-alpha : A spectroscopic and thermodynamic approach to study metal binding in Intrinsically disordered proteins
(East Carolina University, 2014)The goal of this study is to provide a deeper insight into how metals bind intrinsically disordered proteins (IDPs) by taking zinc binding to prothymosin-alpha as a case study. The involvement of metals in several diseases ... -
Investigations into the Oldest Standing Structure in North Carolina
(East Carolina University, 1/13/16)In 2010, Steven and Linda Lane purchased 304 East Queen Street, Edenton, North Carolina. While renovating the structure they discovered that it was much older than previously thought. The results of a dendrochronology ... -
Investigations into the roles of bacteroides fragilis thioredoxins during the oxidative stress response
(East Carolina University, 2011)The Gram-negative Bacteroides fragilis is the most frequently isolated bacterium from anaerobic infections. Native to the human intestinal tract, it serves a symbiotic role breaking down complex polysaccharides and ... -
Investigations of the Brevard Fault zone and Tugaloo Terrane adjacent to the Grandfather Mountain Window, North Carolina
(East Carolina University, 2023-07-24)The Brevard Fault Zone adjacent to the Grandfather Mountain window, NC is interpreted to be a terrane boundary between Laurentian margin rocks and accreted rocks of the Tugaloo Terrane. Structural, geochemical, and ... -
Investigations Of The Impact Of Altered Auditory Feedback In-The-Ear Devices On The Speech Of People Who Stutter: Initial Fitting And Four-Month Follow-Up
(East Carolina University, 2004)Background: Self-contained ear-level devices delivering altered auditory feedback (AAF) for the application with those who stutter were only recently developed (Stuart et al. 2003). Aim: This paper examines the first ... -
Investigations Of The Impact Of Altered Auditory Feedback In-The-Ear Devices On The Speech Of People Who Stutter: One-Year Follow-Up
(East Carolina University, 2006)Purpose: This study examined objective and subjective measures of the effect of a self-contained ear-level device delivering altered auditory feedback (AAF) for those who stutter 12 months following initial fitting with ... -
Investors’ Perceptions of Potentially Fraudulent Environmental, Social, and Governance Disclosures
(East Carolina University, 2023-05-15)Investor’s Perceptions regarding Fraudulent Environment, Social, and Governance (ESG) Disclosures digs heavily into how important the validity of ESG disclosures are to potential and current investors of a well preforming ... -
Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy
(2011-07)Elucidating the response of breast cancer cells to chemotherapeutic and hormonal based drugs is clearly important as these are frequently used therapeutic approaches. A signaling pathway often involved in chemo- and ... -
Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy
(2011-07-01)Elucidating the response of breast cancer cells to chemotherapeutic and hormonal based drugs is clearly important as these are frequently used therapeutic approaches. A signaling pathway often involved in chemo- and ... -
The involvement of cap-independent mRNA translation in cell fate decisions
(East Carolina University, 2014)During cell stress many biochemical processes are shut down. For example, global mRNA translation initiation is inhibited due to the disruption of the cap-dependent mRNA recruitment mechanism. One specific example of ... -
Involvement of RAB10 in Cognitive Dysfunction Using Trace Eyeblink Classical Conditioning
(East Carolina University, 2023-05-04)Alzheimer’s Disease (AD) is a disorder characterized by progressive memory loss, perceptive inaccuracies, and other issues with neurocognitive function (Khan et al., 2020). Different genetic issues and pathways in the brain ... -
Ion Traffic Across Cellular Membranes
(East Carolina University, 2010)The cell membrane protects the delicate internal machinery of the cell and hosts a complex transport system for ion exchange with the environment. Energy is continually expended to maintain a transmembrane electrical ... -
Ionian Revolt, Reconsidered
(East Carolina University, 2010)In the scope of historical events recorded by Herodotus, no event has been more pivotal in capturing the relationship between the mainland and Ionian Greeks and their enemy, and at times supporter, Persian Empire than the ... -
IRON ISOTOPE GEOCHEMISTRY OF BULK ROCKS AND Fe-Ti OXIDES FROM THE SKAERGAARD LAYERED MAFIC INTRUSION, SE GREENLAND
(East Carolina University, 2019-07-23)Small, but significant fractionation of Fe isotopes occurs in high-temperature igneous rocks. Despite increasing study, the exact causes of this fractionation are still debated. Therefore, a systematic study of a complete ...