Browsing by Subject "Biology"
Now showing items 61-80 of 97
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miRDiabetes : A microRNA-Diabetes Association Database Constructed With Data Mining on Literature
(East Carolina University, 2014)MicroRNAs (miRNAs) are a growing class of non-coding RNAs that regulate gene expression by translational repression. A role for miRNA in diabetes was first established in 2004 and research in miRNA-diabetes association has ... -
Modulation of IKKβ with AMPK Improves Insulin Sensitivity in Skeletal Muscle
(East Carolina University, 2008-11)Activation of the insulin receptor substrate (IRS)-1 is necessary for proper transduction of the insulin signal. IRS-1 serine312(human)/307(rodent) phosphorylation, however, results in disruption of this signal and subsequent ... -
Multiple Factors Influence the Strength of Intraguild Interactions
(East Carolina University, 2011)Species engaged in intraguild predation (IGP) not only compete for the same food resources but can also eat each other. In some cases, a predator species in a higher trophic position (i.e., a top predator) can eat a ... -
Natal Origin of Central Southern Management Area, North Carolina Striped Bass, Inferred from Otolith Microchemistry
(East Carolina University, 2013)Striped bass (Morone saxatilis) is an important commercial and game fish throughout North Carolina coastal waters. These fish have spawning populations present in all of the state's coastal rivers, however populations south ... -
Neurological Effects Of A Single Low Level Blast Overpressure Exposure : Behavior And Micro RNA Mechanisms Of Mild Traumatic Brain Injury In A Rodent Model
(East Carolina University, 2015)The increased use of explosive devices within warfare and acts of terrorism has allowed blast overpressure exposure (BOE) to become a significant concern. The most common wound sustained by BOE is blast-induced mild traumatic ... -
p53 and NGAL: dual regulatory roles in advanced prostate cancer
(East Carolina University, 2011)The development of prostate cancer from small regions of hyperplasia to invasive tumors requires genetic and epigenetic alterations of critical cellular components to aid in the development of cells more adapted for aberrant ... -
Photofrin-Mediated Electroporation-Assisted Photodynamic Therapy of MCF-7 Human Breast Cancer and B16-F10 Mouse Melanoma Cells
(East Carolina University, 2011)Photodynamic therapy is a relatively new player on the field of cancer treatment that involves the injection of a nontoxic light-sensitive drug followed by light excitation, creating reactive oxygen species that cause ... -
Phylogenetics and Systematics of the Millipede genus Brachycybe Wood, 1864 (Platydesmida: Andrognathidae)
(East Carolina University, 2010)The genus Brachycybe Wood, 1864 (Platydesmida: Andrognathidae) belongs to an ancient millipede lineage that has persisted since the Miocene. The group displays a Holarctic distribution with species in the eastern Nearctic, ... -
Physiological and Phylogenetic Studies of the Biogeography of Alkaliphilic Heterotrophic Bacteria from Serpentinizing Habitats
(East Carolina University, 2014)Serpentinization occurs when ultramafic rocks containing the mineral olivine react with water to produce highly reducing conditions, which are commonly coincident with high concentrations of hydrogen. Hydrogen provides ... -
Physiological Studies of Alkaliphilic Anaerobic Organotrophs in a Serpentinizing Subsurface Habitat
(East Carolina University, 2014)Microbial habitats in serpentinizing ultramafic rocks represent one of the largest, yet least understood portions of the biosphere, with potentially major consequences for global biogeochemical cycles. Serpentinization is ... -
Population Structure Of River Herring In Albemarle Sound, North Carolina, Inferred From Geometric Morphometrics And Otolith Shape Analysis
(East Carolina University, 2015)Alewife Alosa pseudoharengus and Blueback Herring Alosa aestivalis, collectively known as River herring, use tributaries of the Albemarle Sound, North Carolina as spawning and nursery habitats. Stocks of these anadromous ... -
Possible Effects Of Climate Change On Induced Defenses In Tadpoles
(East Carolina University, 2015)Global climates are changing and the rate of change is expected to increase in the next century. Researchers predict that temporary ponds will be affected, resulting in shorter average hydroperiods (the amount of time a ... -
Rectifying Limitations On Species Delineation In Dusky Salamanders : Lineage Detection Using An Ecoregion-Drainage Sampling Regime
(East Carolina University, 2015)The dusky salamanders (Desmognathus) constitute a large, species-rich group, and although a considerable body of literature exists on systematic relationships and adaptive trends, these issues have heretofore been approached ... -
Repair of Clustered DNA Lesions in Double Strand Break Repair Deficient Human Tumor Cells
(East Carolina University, 2010)DNA-dependent protein kinase (DNA-PK) is a holoenzyme of three subunits, Ku70, Ku80, and the DNA-Pk catalytic subunit (DNA-PKcs). DNA-PK serves a role in non-homologous end joining to repair double stranded breaks, and ... -
REPRODUCTIVE ISOLATION AND MIMETIC DIVERGENCE IN THE POISON FROG RANITOMEYA IMITATOR
(East Carolina University, 2014)Understanding the process of speciation requires examination of various stages of its progress. This work focuses on the early stages of population divergence, where populations of a single species may show varying levels ... -
Reproductive Plasticity In Two Subspecies Of A Cleistogamous Plant, Triodanis Perfoliata
(East Carolina University, 2015)Dimorphic cleistogamy is an intriguing reproductive strategy in which a plant produces both closed (cleistogamous), obligately selfing flowers and open (chasmogamous) flowers. Phenotypic plasticity in the production of ... -
RESPONSE OF A SPARTINA PATENS-DOMINATED OLIGOHALINE MARSH TO NITROGEN ENRICHMENT IN COASTAL NORTH CAROLINA, USA.
(East Carolina University, 2013)Coastal marshes are highly productive ecosystems that play a significant role in the global carbon budget. Anthropogenic alterations to coastal landscapes can significantly impact these marsh ecosystems, though the actual ... -
Responses of Leaf Litter Breakdown Rates and Microbial Enzyme Activity to Salinity in North Carolina Wetlands
(East Carolina University, 2014)Sea-level rise and human activities are causing the increase of salinity in coastal freshwater wetlands. Increased salinity in some wetlands has been found to accelerate leaf litter decomposition, an important driver of ... -
River Herring Nursery Habitat in Albemarle Sound, North Carolina, Inferred from Otolith Microchemistry
(East Carolina University, 2012)River herring is a collective term used to describe two similar alosine species: alewife Alosa pseudoharengus and blueback herring A. aestivalis. Both of these anadromous species are native to the Atlantic coast of North ... -
RNA polymerase II CTD Evolutionary Diversity and Associated Protein Identification in Green and Red Algae
(East Carolina University, 2014)In model eukaryotes, the C-terminal domain (CTD) of the largest subunit (RPB1) of DNA-dependent RNA polymerase II is composed of tandemly repeated heptads with the consensus sequence YSPTSPS. Both the core motif and tandem ...