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Microarray and pathway analysis reveals decreased CDC25A and increased CDC42 associated with slow growth of BCL2 overexpressing immortalized breast cell line
(East Carolina University, 2008-10)Bcl-2 is an anti-apoptotic protein that is frequently overex-pressed in cancer cells but its role in carcinogenesis is not clear. We are interested in how Bcl-2 expression affects non-cancerous breast cells and its role ... -
Microbial Carbon Assimilation within the Walls of Deep-sea Hydrothermal Vent Chimneys
(East Carolina University, 2011)Carbon is one of the most abundant elements on Earth stored in a multitude of reservoirs and constantly cycled through various processes occurring on our planet. Although it represents only a small percentage of the total ... -
Microbial community response to environmental change during the Anthropocene
(East Carolina University, 2021-05-03)Microbial community composition and functional potential can be affected by human-derived environmental changes during the Anthropocene with important consequences for elemental cycling and whole ecosystem processes. This ... -
MICROBIAL DIVERSITY AND BIOGEOGRAPHY IN A SERPENTINITE-HOSTED ECOSYSTEM
(East Carolina University, 2010)The goal of this project was to characterize the taxonomic and functional diversity and document biogeographic patterns of microbial communities in an ecosystem influenced by active serpentinization. Serpentinization is a ... -
MICROBIAL INFLUENCED CORROSION ON ACCOMAC, A FRESHWATER, FERROUS-HULLED SHIPWRECK: EVALUATION OF MICROBIAL DIVERSITY AND COMPOSITION
(East Carolina University, 2023-07-09)Abandoned shipwrecks are sitting at the bottom of oceans and lakes around the world, deteriorating extensively as the years pass by. Over time, however, microbial-comprised biofilm formation on these structures has resulted ... -
Microglial dysfunction as an early susceptibility to Alzheimer's disease: the exacerbating role of developmental toxicity
(East Carolina University, 2017-07-25)The association between perturbations to neuroimmune development and susceptibility to adult neurodegenerative diseases, like Alzheimer's disease (AD), may undersore a putative pathogenic role for gradual microglial ... -
MICROMORPHOLOGY IN ARCHAEOLOGY: AN ANALYSIS OF EOLIAN AND ALLUVIAL SITE FORMATION PROCESSES IN THE MIDDLE RÍO NEGRO VALLEY, NORTHERN PATAGONIA, ARGENTINA
(East Carolina University, 2022-07-19)Based on the results of a previous geoarchaeological study that reconstructed the landscape history of the Middle Río Negro Valley in Northern Patagonia, Argentina, this thesis analyzes previously collected sediments to ... -
MICROMORPHOLOGY IN ARCHAEOLOGY: AN ANALYSIS OF EOLIAN AND ALLUVIAL SITE FORMATION PROCESSES IN THE MIDDLE RÍO NEGRO VALLEY, NORTHERN PATAGONIA, ARGENTINA
(East Carolina University, 2022-07-19)Based on the results of a previous geoarchaeological study that reconstructed the landscape history of the Middle Río Negro Valley in Northern Patagonia, Argentina, this thesis analyzes previously collected sediments to ... -
MICRONOME AND KSHV INFECTION: IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF CELLULAR MICRORNAS DURING VIRUS ENTRY
(East Carolina University, 2018-04-17)Kaposi's sarcoma-associated herpesvirus (KSHV), is the most recently identified human herpesvirus and causes a variety of human malignancies. KSHV is etiologically associated with Kaposi's sarcoma (KS), primary effusion ... -
MicroRNA Expression Analysis in the Cellulosic Biofuel Crop Switchgrass () under Abiotic Stress
(2012)Switchgrass has increasingly been recognized as a dedicated biofuel crop for its broad adaptation to marginal lands and high biomass. However, little is known about the basic biology and the regulatory mechanisms of gene ... -
MicroRNA expression analysis in the cellulosic biofuel crop switchgrass (panicum virgatum) under abiotic stress
(2012-03-28)Switchgrass has increasingly been recognized as a dedicated biofuel crop for its broad adaptation to marginal lands and high biomass. However, little is known about the basic biology and the regulatory mechanisms of gene ... -
MicroRNA expression profiles during cotton (Gossypium hirsutum L) fiber early development
(2017-03-22)The role of microRNAs (miRNAs) during cotton fiber development remains unclear. Here, a total of 54 miRNAs belonging to 39 families were selected to characterize miRNA regulatory mechanism in eight different fiber development ... -
MicroRNA profiling in the left atrium in patients with non-valvular paroxysmal atrial fibrillation
(2015)identifying miRNAs that were significantly associated with non-valvular paroxysmal AF. Methods: The RNA samples were isolated from healthy controls (n = 5) and patients with atrial fibrillation (n = 8). To confirm the ... -
MicroRNA profiling in the left atrium in patients with non-valvular paroxysmal atrial fibrillation
(2015-08)Background We aimed to identify the miRNA expression profiles in left atrial appendage, with the intention of identifying miRNAs that were significantly associated with non-valvular paroxysmal AF. Methods The RNA ... -
MicroRNA-431 regulates axon regeneration in mature sensory neurons by targeting the Wnt antagonist
(2013-10)MicroRNAs (miRNAs) are small, non-coding RNAs that function as key post-transcriptional regulators in neural development, brain function, and neurological diseases. Growing evidence indicates that miRNAs are also important ...