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Notched Acoustic Stimulus and Tinnitus: A Treatment Intervention Using a Randomization Test Approach
(East Carolina University, 2014)Musical training has considerable effects on human brain plasticity and music listening has been investigated as a means of treating tinnitus. In a laboratory setting, tailor-made notched music has been shown to reduce ... -
Note taking skills using the LiveScribe pen: implications for college students diagnosed with learning disabilities
(East Carolina University, 2014)The purpose of this study was to examine whether the use of strategic note-taking with the LiveScribe© pen increased the quantity of idea units, quality of notes written down, and retention of information provided for ... -
A Novel A1 Adenosine Receptor Antagonist, L-97-1 [3-[2-(4-Aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3,7-dihydro-purine-2,6-dione], Reduces Allergic Responses to House Dust Mite in an Allergic Rabbit Model of Asthma
(East Carolina University, 2005-10)Adenosine, an important signaling molecule in asthma, produces bronchoconstriction in asthmatics. Adenosine produces bronchoconstriction in allergic rabbits, primates, and humans by activating A1 adenosine receptors (ARs). ... -
Novel autoinducer molecules and uses therefor
(2002-03-07)Novel bacterial quinolone signal molecules and, more particularly, pseudomonas quinolone signal ('PQS') molecules, e.g., 2-heptyl-3hydroxy-4-quinolone, and analogs and derivatives thereof are described, Therapeutic ... -
NOVEL BIOLOGICS PROMOTE STABLE EXPANSION OF REGULATORY CD25HIGH FOXP3+ T LYMPHOCYTES AS A MEANS FOR AN ADOPTIVE CELL-BASED IMMUNOTHERAPY
(East Carolina University, 2021-06-18)Autoimmune disease arises when a breakdown in immunological self-tolerance causes self-reactive tissue destruction. In Multiple Sclerosis (MS), myelin reactive CD4+ T cells initiate an immune attack on the myelin sheath ... -
Novel Combination of Sorafenib and Celecoxib Provides Synergistic Anti-Proliferative and Pro-Apoptotic Effects in Human Liver Cancer Cells
(2013)Molecular targeted therapy has shown promise as a treatment for advanced hepatocellular carcinoma (HCC). Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced HCC. However, although ... -
Novel Combination of Sorafenib and Celecoxib Provides Synergistic Anti-Proliferative and Pro-Apoptotic Effects in Human Liver Cancer Cells
(2013-06-12)Molecular targeted therapy has shown promise as a treatment for advanced hepatocellular carcinoma (HCC). Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced HCC. However, although ... -
A novel DAG-dependent mechanism links PKCa and Cyclin B1 regulating cell cycle progression
(2014-11)Through the years, different studies showed the involvement of Protein Kinase C (PKC) in cell cycle control, in particular during G1/S transition. Little is known about their role at G2/M checkpoint. In this study, using ... -
Novel diagnostic and analytical applications of benchtop time-domain NMR.
(East Carolina University, 2015)High-resolution nuclear magnetic resonance (NMR) spectroscopy is a powerful technique, yet practical application outside of the research laboratory has been limited due to the high cost and complexity of the instrumentation. ... -
The novel dual PI3K/mTOR inhibitor NVP-BGT226 displays cytotoxic activity in both normoxic and hypoxic hepatocarcinoma cells
(2015-07)Hepatocellular carcinoma (HCC) is one of the most common lethal human malignancies worldwide and its advanced status is frequently resistant to conventional chemotherapeutic agents and radiation. We evaluated the cytotoxic ... -
A Novel Educational Intervention: Improving Abdominal Pressure Strategies during Colonoscopy
(2021-07-23)Gastroenterology (endoscopy) procedures continue to increase in volume as innovative therapeutic endoscopy procedures are performed to meet the increasing demand for minimally invasive procedures. During endoscopy procedures, ... -
Novel Function of PUF Proteins and Their Partners in Spermatogenesis and Spermatocyte-Derived Germline Tumors in Caenorhabditis elegans
(East Carolina University, 2022-04-27)Conserved PUF (Pumilio and FBF) proteins repress the translation by binding to its target mRNA 3' untranslated region (3'UTR). C. elegans has 11 PUF proteins. Among them, we focused on two FBFs (FBF-1 and FBF-2) and PUF-8. ... -
NOVEL MECHANISMS GOVERNING SKELETAL MUSCLE MITOCHONDRIAL BIOENERGETICS : OXPHOS EFFICIENCY AND cAMP/PKA SIGNALING
(East Carolina University, 2014)Understanding the regulation of cellular metabolism is paramount to treating the growing prevalence of metabolic disease worldwide. In cellular metabolism, mitochondrial oxidative phosphorylation (OXPHOS) plays a key role ... -
Novel Nano-Based Antibacterial Therapeutic Against Hospital Acquired Infection
(East Carolina University, 2022-07-19)Rising nosocomial infections, also called hospital-acquired infections (HAIs), are of imminent public health concern as common antibiotics, such as ampicillin and kanamycin, are becoming less effective against bacterial ... -
Novel Nano-Based Antibacterial Therapeutic Against Hospital Acquired Infection
(East Carolina University, 2022-07-19)Rising nosocomial infections, also called hospital-acquired infections (HAIs), are of imminent public health concern as common antibiotics, such as ampicillin and kanamycin, are becoming less effective against bacterial ... -
NOVEL NUCLEOLAR LOCALIZATION OF SYNAPTOPODIN-2 ISOFORM IN PROLIFERATING HT-29 CELLS
(East Carolina University, 2021-07-13)Members of the Synaptopodin family regulate [alpha]-actinin and actin-bundling activity, in an isoform specific manner (Asunama et al., 2005). The ability to affect actin polymerization and bundling highlights the critical ...