Browsing by Title
Now showing items 4687-4706 of 10618
-
Identification of a circular intermediate in the transfer and transposition of Tn4555, a mobilizable transposon from Bacteroides spp.
(East Carolina University, 1993-05)Transmissible cefoxitin (FX) resistance in Bacteroides vulgatus CLA341 was associated with the 12.5-kb, mobilizable transposon, Tn4555, which encoded the 13-lactamase gene cfxA. Transfer occurred by a conjugation-like ... -
Identification of a novel Leucine-rich repeat protein and candidate PP1 regulatory subunit expressed in developing spermatids
(East Carolina University, 2008-01-31)Background: Spermatogenesis is comprised of a series of highly regulated developmental changes that transform the precursor germ cell into a highly specialized spermatozoon. The last phase of spermatogenesis, termed ... -
Identification of a Potential RNAzyme in Brucella abortus with Heme-Dependent Peroxidase Activity
(East Carolina University, 2020-11-19)Bovine brucellosis is of significant concern to the U.S. cattle industry and has not been controlled by vaccination in some areas of the world. The inability to control this pathogen is currently a serious public health ... -
Identification of Biomarkers in Non-Small Cell Lung Cancer Patients Treated with PD-1 Monoclonal Antibody Immunotherapy
(East Carolina University, 2018-08-22)Cancer immunotherapy works by taking a patient's existing immune system and priming it to recognize cancer cells in order for immune cells to mount an effective response to the disease. This is a less invasive means of ... -
Identification of cytosolic phosphodiesterases in the erythrocyte: A possible role for PDE5
(2011)Background Within erythrocytes (RBCs), cAMP levels are regulated by phosphodiesterases (PDEs). Increases in cAMP and ATP release associated with activation of β-adrenergic receptors (βARs) and prostacyclin receptors ... -
Identification of Damaged DNA Adducts from Exposure to Benzo[a]pyrene in the TP53 Gene
(2015)Benzo[a]pyrene is a carcinogen associated with tobacco smoke that can damage DNA after it is metabolized into highly reactive forms. Identifying the resulting DNA adducts can give greater insight into the mutations that ... -
Identification of E2F1 as a positive transcriptional regulator for delta-catenin
(East Carolina University, 2008-05-02)Delta-Catenin is upregulated in human carcinomas. However, little is known about the potential transcriptional factors that regulate delta-catenin expression in cancer. Using a human delta-catenin reporter system, we have ... -
Identification of Extracellular d-Catenin Accumulation for Prostate Cancer Detection
(East Carolina University, 2009-03-01)BACKGROUND—Prostate cancer is the second leading cause of cancer death in men, and early detection is essential to reduce mortality and increase survival. δ-Catenin is a unique β-catenin superfamily protein primarily ... -
Identification of Factors Associated with the Development and Decay of Heterologous Tolerance to Morphine in the Guinea Pig
(East Carolina University, 2016-05-03)It is believed that the heterologous tolerance that develops upon chronic exposure to morphine is the result of adaptive changes in the cellular signaling pathways associated with the [mu] opioid receptor. Proposed adaptive ... -
IDENTIFICATION OF FACTORS THAT CONTRIBUTE TO AN INCREASE IN LIFEGUARD COMPLACENCY
(East Carolina University, 2011)The purpose of this thesis was to identify factors that predict lifeguard complacency in an effort to increase overall vigilance while lifeguarding. Three research questions were explored: (a) what factors contribute to ... -
Identification of galectin-1 as a marker for claudin-low breast cancer and implications for tumor progression
(East Carolina University, 2024-01-04)Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer. Patients with TNBC have a high rate of metastasis and mortality due to the lack of targeted therapies and resistance to chemotherapy. This ... -
IDENTIFICATION OF GEOCHEMICAL TRACERS WITHIN BIOMINERALS OF JUVENILE AND LARVAL MERCENARIA MERCENARIA : IMPLICATIONS FOR MODELING LARVAL DISPERSAL
(East Carolina University, 2013)This study was designed to investigate the application of geochemical signals within biominerals to identify site fidelity and natal origin of the commercially valuable bivalve Mercenaria mercenaria. My first study ... -
IDENTIFICATION OF IRON-OXIDIZING BACTERIA ON STEEL STRUCTURES IN FRESHWATER ENVIRONMENTS
(East Carolina University, 2023-04-26)Microorganisms found on steel structures within aquatic systems impact the integrity of the structures and environmental factors surrounding them. Iron-oxidizing bacteria (FeOB) in particular, can cause damage and corrosion ... -
IDENTIFICATION OF NOVEL CYTOTOXIC PROSTAGLANDIN METABOLITES PRODUCED IN ARACHIDONOYL ETHANOLAMIDE-TREATED TUMOREGENIC KERATINOCYTES
(East Carolina University, 2012)Arachidonoyl ethanolamide (AEA) induces apoptosis in mouse tumorigenic keratinocytes (JWF-2 cells). Our previous data show that AEA is metabolized by COX-2 to pro-apoptotic J-series prostaglandins. COX-2 is an enzyme that ... -
Identification of Residual Neuromuscular Blockade in Post-Surgical Patients
(2017-11-19)Background: Many surgical procedures require administration of nondepolarizing neuromuscular blocking (NDNMB) agents. NDNMBs are typically reversed when surgery ends, allowing function to be restored. With more precise ... -
Identification of Stress in Latino Families who have Young Exceptional Children
(East Carolina University, 2014)The Latino population in the US is growing and there are many stressors that can accompany life in a new country; much more so when a family has a child with special needs. The aim of the present study is to explore the ... -
Identification of the Cu(II) Coordinating Residues in the Prion Protein by Metal-Catalyzed Oxidation Mass Spectrometry: Evidence for Multiple Isomers at Low Cu(II) Loadings
(East Carolina University, 2008-09-02)While the Cu(II) binding sites of the prion protein have been well studied under Cu-saturation conditions, the identity of the residues involved in coordinating Cu(II) at low stoichiometries and the order in which the ... -
Identification of Vape Shops in Two North Carolina Counties: An Approach for States without Retailer Licensing
(2016-10-27)Stores that sell electronic nicotine delivery systems (ENDS) as their primary product are a new phenomenon and often termed “vape shops”. While vape shops are now regulated by state and federal agencies, not all states ...