Browsing by Author "Biomedical Sciences"
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30-Day Immunotoxicity Study of PFMOAA in C57BL/6 Mice
Vance, Samuel (East Carolina University, 2019-07-18)Within the past five years, two classes of per- and polyfluoroalkyl substances (PFAS) were phased out of production in the U.S., which led to the development and production of PFAS to replace these two major classes. One ... -
Activation of the proton sensing G-protein coupled receptor, GPR4, regulates focal adhesion dynamics and delays cell spreading due to increased cytoskeletal tension
Justus, Calvin Richard (East Carolina University, 2013)The tumor microenvironment is characteristically acidic due to insufficient blood perfusion, chronic inflammation, hypoxia, and altered cell metabolism. The low pH found in the tumor microenvironment may facilitate the ... -
ASSESSMENT OF MITOCHONDRIAL ENERGETICS IN A SKELETAL MUSCLE RESISTANT TO HYPOXIA.
Mooney, Serena (East Carolina University, 2021-04-23)Skeletal muscle is dependent upon oxygen (O2) to maintain normal physiological function by acting as the final electron acceptor in the mitochondria during ATP production. Loss of O2 tension (i.e. hypoxia) leads to the ... -
The contribution of motility and chemotaxis in the Borrelia burgdorferi infectious life cycle
Yerke, Aaron (East Carolina University, 2013)Lyme disease has emerged as an increasing problem for people in the east and northeastern part of the United States. It can cause a chronic debilitating infection if left untreated and is difficult to diagnose. The illness ... -
Determining the role of BRCA1 in skeletal muscle regeneration
Williamson, Nicholas C (East Carolina University, 2022-07-15)Skeletal muscle is necessary for movement, breathing, and performance of daily activities. Acute injuries can occur to skeletal muscle, and there are several conditions and diseases that result in impairment of muscle ... -
Developmental lead exposure and the exacerbation of Alzheimer's pathology: an immunological analysis
Vonderembse, Annalise Noelle (East Carolina University, 2014)Early neuroimmune dysfunction may play a driving role in the etiopathology of Alzheimer's disease (AD), stemming from the hypothesis that many late-stage adult diseases have an early-life basis. Here we explore whether ... -
Dopaminergic modulation of the autonomic nervous system: in vitro and in vivo evidence from the mouse
Johnson, Tracy L. (East Carolina University, 2012)Central nervous system (CNS) function depends on both the connections between the underlying neurons and neural circuits and their activity. Neuronal activity in turn can be classified as neurotransmission and neuromodulation, ... -
THE EFFECTS OF ACIDIC TUMOR MICROENVIRONMENT ON LYMPHOMA CELL RESPONSES TO CHEMOTHERAPEUTICS
Yu, Zhou (East Carolina University, 2014)Acidic tumor microenvironment exists in many types of cancer. Altered glycolytic metabolism of tumor cells and deficient blood supply in tissues are major causes for this phenomenon. Lymphoma cells may have different ... -
Effects of PFMOAA, An Understudied PFAS, on Developing Mice
Stewart, Erica J (East Carolina University, 2021-08-16)Perfluoro-2-methoxyaacetic acid (PFMOAA) was recently the most prevalent emerging per- and polyfluoroalkyl substance (PFAS) detected in the Cape Fear River of North Carolina (NC). A byproduct of fluorochemical manufacturing, ... -
EXERCISE AND DIET PROGRAMS DROSOPHILA SIMULANS OFFSPRING METABOLIC PHENOTYPE
Johnson, Aaron M (East Carolina University, 2021-04-23)Obesity in pediatric patients has increased significantly in recent decades, along with susceptibility to Type 2 Diabetes (T2D), cardiovascular disease, cancer, and mortality. The relative contribution of genetic and ... -
Expression of microRNA in Alveolar Macrophages Deficient in PPARy
McPeek, Matthew (East Carolina University, 2014)The nuclear transcription factor Peroxisome proliferator-activated receptor gamma (PPARgamma) is a negative regulator of macrophage activation and inflammatory mediators. Alveolar macrophages of healthy individuals ... -
Fesselin, an intrinsically disordered smooth muscle protein, organizes and stabilizes actin-myosin and myosin
Kingsbury, Nathaniel (East Carolina University, 2014)Fesselin is an intrinsically disordered protein that is known to bind a large variety of cytoskeletal proteins. The proteins fesselin is known to bind include: actin (Leinweber et al. 1999), [alpha]-actinin (Pham et al. ... -
Genetic and hypoxic effects on germline tumor development in caenorhabditis elegans
Datla, Udaya Sree (East Carolina University, 2013)The process of differentiation of stem cells to committed, progenitor specific cell types is well studied but the reverse process of the dedifferentiation of these committed cells back to the undifferentiated state still ... -
Genetic control of cell fate specification in Caenorhabditis elegans germline.
Mamillapalli, Srivalli Swathi (East Carolina University, 2015)The precise regulation of germ cell fates (sperm or oocyte) lies at the heart of reproduction and fertility. The nematode Caenorhabditis elegans hermaphrodites produce a discrete number of sperm during larval development ... -
Identification of Biomarkers in Non-Small Cell Lung Cancer Patients Treated with PD-1 Monoclonal Antibody Immunotherapy
Atwell, Druid Carlisle (East Carolina University, 2018-08-22)Cancer immunotherapy works by taking a patient's existing immune system and priming it to recognize cancer cells in order for immune cells to mount an effective response to the disease. This is a less invasive means of ... -
Impaired N-Glycosylation Processing Impacts Neuronal Function
Hatchett, Cody J (East Carolina University, 2021-07-29)Modifications of membrane proteins are carried out primarily using N-linked glycosylation. N-glycosylation has the potential to co-translationally and post-translationally modify protein function by the addition and ... -
Interrelated role of Notch signaling and mTORC pathways in prostate cancer cell survival and growth
Nutter, Jennifer Makenzie (East Carolina University, 2014)Prostate cancer is currently the second highest leading cause of cancer death in men. Notch is a transmembrane receptor protein that is part of a signaling pathway necessary in the normal development of the prostate. ... -
Intratracheal instillation of silver nanoparticles exacerbates cardiac ischemia/reperfusion injury in male sprague-dawley rats
Holland, Nathan A. (East Carolina University, 2014)The uses of engineered nanomaterials have expanded in biomedical technology and consumer manufacturing. Exposure to particulate matter has been demonstrated to negatively influence cardiovascular health and expand myocardial ... -
INVESTIGATING THE MOLECULAR MECHANISMS UNDERLYING SKIN FRAGILITY IN TP63-LINKED ECTODERMAL DYSPLASIAS
Gugger, Jessica A (East Carolina University, 2022-04-28)Ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome and ectrodactyly-ectodermal dysplasia-cleft lip/palate (EEC) syndrome are two rare autosomal dominant disorders caused by heterozygous mutations occurring ... -
Investigating the Role of Poxvirus Virulence Genes A35 and O1L in the Virus Life Cycle
Hayes, Alexandra G (East Carolina University, 2019-07-22)Poxviruses, some of the largest viruses in existence, have a great impact on the human and animal world due to their ability to infect a broad assortment of organisms and cause significant disease. Today, poxvirus infections ...