Browsing by Author "Bunner, Wyatt"
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Administration of alpha klotho reduces liver and adipose lipid accumulation in obese mice
Rao, Zhijian; Landry, Taylor; Li, Peixin; Bunner, Wyatt; Laing, Brenton Thomas; Yuan, Yuan; Huang, Hu (2019-04-05)α-Klotho, a known anti-aging protein, exerts diverse physiological effects including: maintenance of phosphate and calcium homeostasis, modulation of cell proliferation, and enhanced buffering of reactive oxygen species. ... -
AgRP neuron activity is required for acute exercise-induced feeding
Bunner, Wyatt (East Carolina University, 2019-08-13)While much is known about the role of neuropeptide Y/agouti-regulated peptide (NPY/AgRP) and pro-opiomelanocortin (POMC) neurons to regulate energy homeostasis, little is known about how forced energy expenditure, such as ... -
AgRP/NPY Neuron Excitability Is Modulated by Metabotropic Glutamate Receptor 1 During Fasting
Laing, Brenton Thomas; McClung, Joseph M.; Li, Peixin; Schmidt, Cameron Alan; Bunner, Wyatt; Yuan, Yuan; Landry, Taylor; Prete, Amber; Huang, Hu (2018-09-03) -
Behavioral and Transcriptome Profiling of Heterozygous Rab10 Knock-Out Mice
Bunner, Wyatt; Wang, Jie; Cohen, Sarah; Bashtovyy, Denys; Perry, Rachel; Shookster, Daniel; Landry, Taylor; Harris, Elizabeth M.; Stackman, Robert; Tran, Tuan D.; Yasuda, Ryohei; Szatmari, Erzsebet M. (2023-05-08)A central question in the field of aging research is to identify the cellular and molecular basis of neuroresilience. One potential candidate is the small GTPase, Rab10. Here, we used Rab101/ mice to investigate the ... -
Centrally Circulating α-klotho Inversely Correlates with Human Obesity and Modulates Arcuate Cell Populations in Mice
Huang, Hu; Shookster, Daniel; Landry, Taylor; Li, Peixin; Jiang, Zhiying; Li, Hongli; Laing, Brenton Thomas; Bunner, Wyatt; Langton, Theodore; Tong, Qingchun (2021) -
The effects of exercise on hypothalamic neurodegeneration of Alzheimer’s disease mouse model
Do, Khoa; Laing, Brenton Thomas; Landry, Taylor; Bunner, Wyatt; Mersaud, Naderi; Matsubara, Tomoko; Li, Peixin; Yuan, Yuan; Lu, Qun; Huang, Hu (2018-01-02)Alzheimer’s disease is a neurodegenerative disorder that affects the central nervous sys- tem. In this study, we characterized and examined the early metabolic changes in the triple transgenic mouse AD model (3xtg-AD), and ...