Browsing by Author "Flickinger, Edward G."
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An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects.
Dohm, G. Lynis; Tapscott, Edward B.; Pories, Walter J.; Dabbs, David J.; Flickinger, Edward G.; Meelheim, Diane; Fushiki, Tohru; Atkinson, Samuel M.; Elton, Charles W.; Caro, Jose F. (East Carolina University, 1988-08)We have developed an in vitro muscle preparation suitable for metabolic studies with human muscle tissue and have investigated the effects of obesity and non-insulin-dependent diabetes mellitus (NIDDM) on glucose transport. ... -
Insulin-like growth factor I binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal rat liver.
Caro, Jose F.; Poulos, John; Ittoop, Olivia; Pories, Walter J.; Flickinger, Edward G.; Sinha, Madhur K. (East Carolina University, 1988-04)Insulin-like growth factor-I (IGF-I) in human hepatoma cells (HEP-G2) has, in addition to its effect on cell growth, shortterm metabolic effects acting through its own receptor. We have demonstrated that normal ... -
Is type II diabetes mellitus (NIDDM) a surgical disease?
Pories, Walter J.; MacDonald, Kenneth G. Jr.; Flickinger, Edward G.; Dohm, G. Lynis; Sinha, Madhur K.; Barakat, Hisham A.; May, Harold J.; Khazanie, Prabhaker; Swanson, Melvin S.; Morgan, Elizabeth J.; Leggett-Frazier, Nancy; Long, Stuart D.; Brown, Brenda M.; O'Brien, Kevin F.; Caro, Jose F. (East Carolina University, 1992-06)Since February 1, 1980, 515 morbidly obese patients have undergone the Greenville gastric bypass (GGB) operation. Of these, 212 (41.2%) were euglycemic, 288 (55.9%) were either diabetic or had glucose intolerance, and ... -
Long-term effect of insulin on glucose transport and insulin binding in cultured adipocytes from normal and obese humans with and without non-insulin-dependent diabetes.
Sinha, Madhur K.; Taylor, Lucy G.; Pories, Walter J.; Flickinger, Edward G.; Meelheim, Diane; Atkinson, Samuel M.; Sehgal, Narinder S.; Caro, Jose F. (East Carolina University, 1987-10)We have tested the hypothesis that in vitro exposure of insulin- resistant adipocytes with insulin results in improved insulin action. A primary culture system of adipocytes from obese subjects with ...