Browsing by Author "Fry, Nate J."
-
Hypoxia and Hypoglycemia synergistically regulate mRNA stability
Carraway, Kristen R.; Johnson, Ellen M.; Kauffmann, Travis C.; Fry, Nate J.; Mansfield, Kyle D. (2017-07)Ischemic events, common in many diseases, result from decreased blood flow and impaired delivery of oxygen and glucose to tissues of the body. While much is known about the cellular transcriptional response to ischemia, ... -
N6-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression
Fry, Nate J.; Law, B. A.; Ilkayeva, O. R.; Holley, C. L.; Mansfield, Kyle D.; Carraway, Kristen R. (2018-07-27)The mRNA modification N6-methyladenosine (m6A) is involved in many post-transcriptional regulatory processes including mRNA stability and translational efficiency. However, it is also imperative to correlate these processes ... -
N6-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression
Fry, Nate J.; Law, Brittany A.; Ilkayeva, Olga R.; Carraway, Kristen R.; Holley, Christopher L.; Mansfield, Kyle D. (2018-07-27)The mRNA modification N6-methyladenosine (m6A) is involved in many post- transcriptional regulatory processes including mRNA stability and translational efficiency. However, it is also imperative to correlate these processes ... -
N6-methyladenosine is required for the hypoxic stabilization of specific mRNAs
Fry, Nate J.; Law, BRITTANY A.; ILKAYEVA, OLGA R.; Holley, CHRISTOPHER L.; MANSFIELD, KYLE D. (2017-09)Post-transcriptional regulation of mRNA during oxygen deprivation, or hypoxia, can affect the survivability of cells. Hypoxia has been shown to increase stability of a subset of ischemia-related mRNAs, including VEGF. RNA ... -
THE ROLE OF N6-METHYLADENOSINE IN HYPOXIA AND CELLULAR TRANSFORMATION
Fry, Nate J. (East Carolina University, 2017-11-29)Cancer is a prevalent disease that affects millions of people each year across the globe. In an effort to find therapies to the many types of cancers, regulation of protein expression through transcription and translation ...