Browsing by Author "Gordon, Scott Edward"
-
5'-AMP-Activated Protein Kinase and Eukaryotic Elongation Factor 2 Response to Resistance Exercise in Young Versus Old Men and Women
Harper, Bradley M. (East Carolina University, 2009)It has been shown that skeletal muscle 5'-AMP-activated protein kinase (AMPK) phosphorylation and/or activity is more greatly elevated in response to resistance exercise or loading in aged rats, and that eukaryotic elongation ... -
AMP-activated protein kinase response to contractions and treatment with the AMPK activator AICAR in young adult and old skeletal muscle
Thomson, D. M.; Brown, J. D.; Fillmore, N.; Ellworth, S. K.; Jacobs, D. L.; Winder, W. W.; Fick, C. A.; Gordon, Scott Edward (East Carolina University, 2009-05-01)One characteristic of aging skeletal muscle is a decline in mitochondrial function. Activation of AMP-activated protein kinase (AMPK)occurs in response to an increased AMP/ATP ratio,which is one potential result of ... -
Cleaved Caspase-3 Response to Acute Resistance Exercise in Young and Old Men and Women : Relationship to Muscle Glycogen Content and 5'-AMP-Activated Protein Kinase (AMPK) Activity
Choplin, Eric Seneca (East Carolina University, 2011)In addition to suppressing protein synthesis and activating protein degradation in skeletal muscle and other cell types, 5'-AMP-activated protein kinase (AMPK) is known to stimulate nuclear apoptosis in non-muscle cells ... -
Does AMP-Activated Protein Kinase Negatively Mediate Aged Fast-Twitch Skeletal Muscle Mass?
Gordon, Scott Edward; Lake, Jordan A.; Westerkamp, Christopher M.; Thomson, David M. (East Carolina University, 2008-10)The activity of 5'-adenosine monophosphate–activated protein kinase, a negative regulator of cell size, is up-regulated with age in resting and overloaded fast-twitch skeletal muscle but not slowtwitch muscle. Here, we ... -
Effects of Dietary Leucine Supplementation on Muscle Mass and Markers of Protein Degradation in Overloaded Skeletal Muscles of Young Adult and Aged Rats
Mixon, William Thomas (East Carolina University, 2011)The hypertrophic response to overload in fast-twitch skeletal muscle is impaired in aged humans and rats, and upregulation of protein degradation pathways are hypothesized to be a contributing factor. Muscle growth occurs ... -
Impaired overload-induced muscle growth is associated with diminished translational signalling in aged rat fast-twitch skeletal muscle
Thomson, David M.; Gordon, Scott Edward (East Carolina University, 2006-07-01)Impaired overload-induced protein synthesis and growth in aged fast-twitch skeletal muscle may result from diminished responsiveness of signalling intermediates controlling protein translation. Yet, potential age-related ... -
Paired Effects of Dietary Leucine Supplementation and Overload on Protein Translational Signaling and Hypertrophy in Aged Rat Skeletal Muscle
Whitworth, Hoke B. (East Carolina University, 2012)Sarcopenia is an age-associated disorder that causes loss of skeletal muscle mass, particularly in type II (fast-twitch) muscle fibers. This loss in muscle mass can cause disability, reductions in the quality of life, and ... -
Skeletal Muscle Eukaryotic Elongation Factor 2 (eEF2) Response to Acute Resistance Exercise in Young and Old Men and Women : Relationship to Muscle Glycogen Content and 5'-AMP-Activated Protein Kinase (AMPK) Activity
Macesich, Jennifer (East Carolina University, 2010)Sarcopenia is associated with an age-related decrease in skeletal muscle mass, which can result in decreases in strength and physical functioning in the older population. Resistance training interventions are not completely ... -
Skeletal Muscle Forkhead Box 3A (FOXO3A) Response to Acute Resistance Exercise in Young and Old Men and Women : Relationship to Muscle Glycogen Content and 5'-AMP Activated Protein Kinase (AMPK) Activity
Tharrington, India Hope (East Carolina University, 2010)In addition to suppressing protein synthesis, 5'-AMP-activated protein kinase (AMPK) stimulates muscle protein degradation through forkhead box transcription factor 3A (FOXO3A), known to promote transcription of mRNAs ...