Browsing by Author "Green, Thomas D."
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Androgen Signaling Promotes Translation of in Prostate Cancer Cells via Phosphorylation of the α Subunit of the Translation Initiation Factor 2
Overcash, Ryan Franklin; Chappell, Vesna A.; Green, Thomas D.; Geyer, Christopher B.; Asch, Adam S.; Ruiz-Echevarría, Maria J. (2013) -
A BAG3 Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy
Spangenburg, Espen; McClung, Joseph M.; McCord, Timothy J.; Ryan, Terence E.; Schmidt, Cameron A.; Green, Thomas D. (2017-07-18) -
Enhanced Avidity Maturation of Antibody to Human Immunodeficiency Virus Envelope: DNA Vaccination with gp120-C3d Fusion Proteins
Ross, Ted M.; Xu, Yan; Green, Thomas D.; Montefiori, David C.; Robinson, Harriet L. (East Carolina University, 2001-06-10)DNA vaccination can elicit both humoral and cellular immune responses and can confer protection against several pathogens. However, DNA vaccines expressing the envelope (Env) protein of human immunodeficiency virus (HIV) ... -
Enhancement of Antibodies to the Human Immunodeficiency Virus Type 1 Envelope by Using the Molecular Adjuvant C3d
Green, Thomas D.; Montefiori, David C.; Ross, Ted M. (East Carolina University, 2003-02)DNA vaccines expressing the envelope (Env) protein of the human immunodeficiency virus have been relatively ineffective at generating high-titer, long-lasting, neutralizing antibodies in a variety of animal models. In this ... -
Extensive Skeletal Muscle Cell Mitochondriopathy Distinguishes Critical Limb Ischemia Patients from Claudicants
McClung, Joseph M.; Ryan, Terence E.; Yamaguchi, Dean J.; Schmidt, Cameron A.; Zeczycki, Tonya N.; Brophy, Patricia; Green, Thomas D.; Tarpey, Michael D.; Karnekar, Reema; Goldberg, Emma J.; Neufer, P. Darrell; Spangenburg, Espen E. (2018-11-02) -
Interventional- and Amputation-Stage Muscle Proteomes in the Chronically Threatened Ischemic Limb
Green, Thomas D.; Karnekar, Reema; Fisher-Wellman, Kelsey H.; Yamaguchi, Dean J.; McClung, Joseph M. (2022) -
Mitochondrial Therapy Improves Limb Perfusion and Myopathy Following Hindlimb Ischemia
McClung, Joseph; Ryan, Terence E.; Schmidt, Cameron A.; Alleman, Rick J.; Tsang, Alvin M.; Green, Thomas D.; Neufer, P. Darrell; Brown, David A. (2016-08-01) -
Muscle cell derived angiopoietin-1 contributes to both myogenesis and angiogenesis in the ischemic environment
McClung, Joseph M.; Reinardy, Jessica L.; Mueller, Sarah B.; McCord, Timothy J.; Kontos, Christopher D.; Brown, David A.; Hussain, Sabah N. A.; Schmidt, Cameron A.; Ryan, Terence E.; Green, Thomas D. (2015-05)Recent strategies to treat peripheral arterial disease (PAD) have focused on stem cell based therapies, which are believed to result in local secretion of vascular growth factors. Little is known, however, about the role ... -
Overexpression of Long-Chain Acyl-CoA Synthetase 5 Increases Fatty Acid Oxidation and Free Radical Formation While Attenuating Insulin Signaling in Primary Human Skeletal Myotubes
Kwak, Hyo-Bum; Woodlief, Tracey L.; Green, Thomas D.; Cox, Julie H.; Hickner, Robert C.; Neufer, P. Darrell; Cortright, Ronald N. (2019-03-31)In rodent skeletal muscle, acyl-coenzyme A (CoA) synthetase 5 (ACSL-5) is suggested to localize to the mitochondria but its precise function in human skeletal muscle is unknown. The purpose of these studies was to define ... -
PFKFB3-Mediated Glycolysis Rescues Myopathic Outcomes in the Ischemic Limb
McClung, Joseph M.; Ryan, Terence E.; Spangenburg, Espen E.; Schmidt, Cameron A.; Tarpey, Michael D.; Amorese, Adam J.; Yamaguchi, Dean J.; Goldberg, Emma J.; Iñigo, Melissa M.R.; Karnekar, Reema; Brophy, Patricia; Green, Thomas D.; Neufer, P. Darrell; Fisher-Wellman, Kelsey H.; Spangenburg, Espen E. (2020-09-17) -
Racial Differences in the Limb Skeletal Muscle Transcriptional Programs of Patients with Critical Limb Ischemia
Terwilliger, Zoe S.; Goldberg, Emma J.; Schmidt, Cameron A.; Karnekar, Reema; Brophy, Patricia; Green, Thomas D.; Zeczycki, Tonya N.; McClung, Joseph M.; Ryan, Terence E.; Yamaguchi, Dean J.; Gabhann, Feilim Mac; Annex, Brian H. (2021-06) -
Targeted Expression of Catalase to Mitochondria Protects Against Ischemic Myopathy in High-Fat Diet-Fed Mice
Spangenburg, Espen; Ryan, Terence E.; Schmidt, Cameron A.; Green, Thomas D.; Neufer, P. Darrell; McClung, Joseph M. (2016-06-09) -
Targeted Expression of Catalase to Mitochondria Protects Against Ischemic Myopathy in High-Fat Diet-Fed Mice
McClung, Joseph; Ryan, Terence E.; Schmidt, Cameron A.; Green, Thomas D.; Spangenburg, Espen E.; Neufer, P. Darrell (2016-06-09) -
Unique V3 Loop Sequence Derived from the R2 Strain of HIV-Type 1 Elicits Broad Neutralizing Antibodies
Young, Kelly R.; Teal, Benjamin E.; Brooks, Yvonne; Green, Thomas D.; Bower, Joseph F.; Ross, Ted M. (East Carolina University, 2004-11)DNA vaccines expressing the envelope (Env) of the human immunodeficiency virus type 1 (HIV-1) have been relatively ineffective at generating high-titer, long-lasting, neutralizing antibodies. In this study, DNA vaccines ...