Browsing by Author "Krewson, Elizabeth A."
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Acidosis Activates Endoplasmic Reticulum Stress Pathways through GPR4 in Human Vascular Endothelial Cells
Dong, Lixue; Krewson, Elizabeth A.; Yang, Li V. (2017-01-27)Acidosis commonly exists in the tissue microenvironment of various pathophysiological conditions such as tumors, inflammation, ischemia, metabolic disease, and respiratory disease. For instance, the tumor microenvironment ... -
Emerging roles for the pH-sensing G protein-coupled receptors in response to acidotic stress
Sanderlin, Edward J; Justus, Calvin R.; Krewson, Elizabeth A.; Yang, Li V. (2015)Protons (hydrogen ions) are the simplest form of ions universally produced by cellular metabolism including aerobic respiration and glycolysis. Export of protons out of cells by a number of acid transporters is essential ... -
The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells
Krewson, Elizabeth A.; Sanderlin, Edward J.; Marie, Mona A.; Akhtar, Shayan Nik; Velcicky, Juraj; Loetscher, Pius; Yang, Li V. (2020-02-21)be activated by protons in the inflamed tissue microenvironment. Herein, we report that acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelialcells through the ...