Browsing by Author "Li, Peixin"
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Administration of alpha klotho reduces liver and adipose lipid accumulation in obese mice
Rao, Zhijian; Landry, Taylor; Li, Peixin; Bunner, Wyatt; Laing, Brenton Thomas; Yuan, Yuan; Huang, Hu (2019-04-05)α-Klotho, a known anti-aging protein, exerts diverse physiological effects including: maintenance of phosphate and calcium homeostasis, modulation of cell proliferation, and enhanced buffering of reactive oxygen species. ... -
AgRP/NPY Neuron Excitability Is Modulated by Metabotropic Glutamate Receptor 1 During Fasting
Laing, Brenton Thomas; McClung, Joseph M.; Li, Peixin; Schmidt, Cameron Alan; Bunner, Wyatt; Yuan, Yuan; Landry, Taylor; Prete, Amber; Huang, Hu (2018-09-03) -
Antisense oligonucleotide and thyroid hormone conjugates for obesity treatment
Cao, Yang; Matsubara, Tomoko; Zhao, Can; Gao, Wei; Peng, Linxiu; Shan, Jinjun; Liu, Zhengxia; Yuan, Fang; Tang, Lingyi; Li, Peixin; Guan, Zhibin; Fang, Zhuyuan; Lu, Xiang; Huang, Hu; Yang, Qin (2017-08-24)Using the principle of antibody-drug conjugates that deliver highly potent cytotoxic agents to cancer cells for cancer therapy, we here report the synthesis of antisense-oligonucleotides (ASO) and thyroid hormone T3 ... -
Centrally Circulating α-klotho Inversely Correlates with Human Obesity and Modulates Arcuate Cell Populations in Mice
Huang, Hu; Shookster, Daniel; Landry, Taylor; Li, Peixin; Jiang, Zhiying; Li, Hongli; Laing, Brenton Thomas; Bunner, Wyatt; Langton, Theodore; Tong, Qingchun (2021) -
The effects of exercise on hypothalamic neurodegeneration of Alzheimer’s disease mouse model
Do, Khoa; Laing, Brenton Thomas; Landry, Taylor; Bunner, Wyatt; Mersaud, Naderi; Matsubara, Tomoko; Li, Peixin; Yuan, Yuan; Lu, Qun; Huang, Hu (2018-01-02)Alzheimer’s disease is a neurodegenerative disorder that affects the central nervous sys- tem. In this study, we characterized and examined the early metabolic changes in the triple transgenic mouse AD model (3xtg-AD), and ...