Browsing by Author "Lust, Robert M."
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Allopurinol improves myocardial reperfusion injury in a xanthine oxidase-free model
Hopson, Steven B.; Lust, Robert M.; Sun, You Su; Zeri, Richard S.; Morrison, Ron F.; Otaki, Masaki; Chitwood, W. Randolph (East Carolina University, 1995-07)The ability of allopurinol to protect against reperfusion injury in the heart has usually been attributed to its xanthine oxidase (XO)- inhibiting properties. Human myocardium how- ever, has exhibited low levels of XO ... -
Amyloid-beta peptide A beta p3-42 affects early aggregation of full-length A beta 1-42
Sanders, Hiromi M.; Lust, Robert M.; Teller, Jan K. (East Carolina University, 2009-05)The major amyloid beta (Aβ) peptides found in the brain of familial and late onset Alzheimer’s disease include the full-length Aβ1-42 and N-terminally truncated, pyroglutamylated peptides Aβp3-42 and Aβp11-42. The ... -
Cardiac and Mitochondrial Adaptations in Response to Aging and Doxorubicin in Rats Bred for Divergent Aerobic Capacities
Larion, Laura (East Carolina University, 2012)Doxorubicin (DOX) remains as one of the most widely prescribed and effective anticancer agents. A major limitation of the therapeutic effectiveness of the drug is the occurrence of irreversible, progressive, dose-dependent ... -
Cardiovascular Outcomes Following Xenobiotic Pulmonary Exposures
Holland, Nathan A. (East Carolina University, 2017-07-06)Cardiovascular disease remains the leading cause of mortality in the developed world. Over the past decades, investigations have demonstrated that pulmonary exposure to xenobiotic particulate matter promotes and exacerbates ... -
Circadian influences on myocardial infarction
Virag, Jitka A. I.; Lust, Robert M. (2014-10-30)Components of circadian rhythm maintenance, or “clock genes,” are endogenous entrainable oscillations of about 24 h that regulate biological processes and are found in the suprachaismatic nucleus (SCN) and many peripheral ... -
Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction
Virag, Jitka A. I.; Lust, Robert M. (2011)Mouse models are a valuable tool for studying acute injury and chronic remodeling of the myocardium in vivo. With the advent of genetic modifications to the whole organism or the myocardium and an array of biological and/or ... -
Coronary artery ligation and intramyocardial injection in a murine model of infarction
Virag, Jitka A.I.; Lust, Robert M. (2011-06-07)Mouse models are a valuable tool for studying acute injury and chronic remodeling of the myocardium in vivo . With the advent of genetic modifications to the whole organism or the myocardium and an array of biological ... -
The Dopamine D3 Receptor Knockout Mouse Mimics Aging-Related Changes in Autonomic Function and Cardiac Fibrosis
Johnson, Tracy L.; Tulis, David A.; Keeler, Benjamin E.; Virag, Jitka A.; Lust, Robert M.; Clemens, Stefan (2013-08-30)Blood pressure increases with age, and dysfunction of the dopamine D3 receptor has been implicated in the pathogenesis of hypertension. To evaluate the role of the D3 receptor in aging-related hypertension, we assessed ... -
Effects of Aerobic Capacity Phenotype on Adaptive Responses to Ischemic Stress
Fontenot, Elizabeth Gail (East Carolina University, 2009)Ischemic disease leads to increased tissue stress by decreasing supply of nutrients adequate to meet energy demands. To maintain functionality, compensatory mechanisms for diminished vascular supply are induced by numerous ... -
Effects of forced artificial selection for endurance running phenotype on cardioprotection
Brinkley, Christopher S. -
Effects of forced artificial selection for endurance running phenotype on cardioprotection
Brinkley, Christopher S. -
Estrogen, ischemic preconditioning and heat shock protein 70 in the heart
Hammonds, Charles D. -
Expansion of cardiac ischemia/reperfusion injury after instillation of three forms of multi-walled carbon nanotubes
Urankar, Rakhee N.; Lust, Robert M.; Mann, Erin; Katwa, Pranita; Wang, Xiaojia; Podila, Ramakrishna; Hilderbrand, Susana C.; Harrison, Benjamin S.; Chen, Pengyu; Ke, Pu Chun; Rao, Apparao M.; Brown, Jared; Wingard, Christopher J. (2012)Background The exceptional physical-chemical properties of carbon nanotubes have lead to their use in diverse commercial and biomedical applications. However, their utilization has raised concerns about human exposure ... -
Fatty acid transporters in adipose tissue : effect of aerobic running phenotype and high fat feeding
Granville, Esther Otelia Victoria -
Impact of pulmonary exposure to gold core silver nanoparticles of different size and capping agents on cardiovascular injury
Holland, Nathan A.; Thompson, Leslie C.; Vidanapathirana, Achini K.; Urankar, Rahkee N.; Lust, Robert M.; Fennell, Timothy R.; Wingard, Christopher J. (2016-08-24)Background:The uses of engineered nanomaterials have expanded in biomedical technology and consumer manufacturing. Furthermore, pulmonary exposure to various engineered nanomaterials has, likewise, demonstrated the ability ... -
INTRINSIC EXERCISE CAPACITY ON HIND LIMB ARTERIAL LIGATION: DIFFERENTIAL IMPACT OF ACTIVE EXERCISE AND ANDROGEN SIGNALING ON POST-ISCHEMIC RECOVERY
Zakari, Madaniah Omar (East Carolina University, 2018-12-21)Peripheral arterial disease (PAD) is a common disease that is frequently caused by atherosclerosis and associated thrombosis, leading to a decrease in the blood supply to the lower extremities. PAD has various treatment ... -
Modulation of experimental autoimmune myocarditis with cytokine-myosin fusion proteins and novel cardiac peptides
Reece, Shaun Patrick (2016-05-16)Infectious agents that induce cross-reactive myocarditic T cell responses may cause autoimmune inflammation of the heart, dilated cardiomyopathy (DCM), and heart failure. The purpose of this study was to evaluate the ... -
The Dopamine D3 Receptor Knockout Mouse Mimics Aging-Related Changes in Autonomic Function and Cardiac Fibrosis
Johnson, Tracy L.; Tulis, David A.; Keeler, Benjamin E.; Virag, Jitka A. I.; Lust, Robert M.; Clemens, Stefan (2013-)