Browsing by Author "Mansfield, Kyle D."
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Characterization of METTL16 as a cytoplasmic RNA binding protein
Nance, Daniel J; Satterwhite, Emily R.; Bhaskar, Brinda; Misra, Sway; Carraway, Kristen R.; Mansfield, Kyle D. (2020-01-15)mRNA modification by N6-methyladenosine (m6A) is involved in many post-transcriptional regulation processes including mRNA stability, splicing and promotion of translation. Accordingly, the recently identified mRNA ... -
Hypoxia and Hypoglycemia synergistically regulate mRNA stability
Carraway, Kristen R.; Johnson, Ellen M.; Kauffmann, Travis C.; Fry, Nate J.; Mansfield, Kyle D. (2017-07)Ischemic events, common in many diseases, result from decreased blood flow and impaired delivery of oxygen and glucose to tissues of the body. While much is known about the cellular transcriptional response to ischemia, ... -
Investigating the Role of CtBP in Colorectal Cancer
Owens, Ashley Brenna (2015-04-29)Recent studies in breast cancer tissue have demonstrated that C-terminal binding protein (CtBP) over-expression induces stem cell-like features and genome instability; whereas CtBP depletion or caloric restriction reverses ... -
m6A Regulates Breast Cancer Proliferation and Migration through Stage-dependent Changes in Epithelial to Mesenchymal Transition Gene Expression
Dorgham, Mohammed G.; Elliott, Brittany A.; Holley, Christopher L.; Mansfield, Kyle D. (2023-11-07)While many factors have been implicated in breast cancer progression, effective treatments are still lacking. In recent years, it has become clear that posttranscriptional regulation plays a key role in the aberrant gene ... -
N6-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression
Fry, Nate J.; Law, B. A.; Ilkayeva, O. R.; Holley, C. L.; Mansfield, Kyle D.; Carraway, Kristen R. (2018-07-27)The mRNA modification N6-methyladenosine (m6A) is involved in many post-transcriptional regulatory processes including mRNA stability and translational efficiency. However, it is also imperative to correlate these processes ... -
N6-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression
Fry, Nate J.; Law, Brittany A.; Ilkayeva, Olga R.; Carraway, Kristen R.; Holley, Christopher L.; Mansfield, Kyle D. (2018-07-27)The mRNA modification N6-methyladenosine (m6A) is involved in many post- transcriptional regulatory processes including mRNA stability and translational efficiency. However, it is also imperative to correlate these processes ... -
THE ROLE OF N6-METHYLADENOSINE IN HYPOXIA AND CELLULAR TRANSFORMATION
Fry, Nate J. (East Carolina University, 2017-11-29)Cancer is a prevalent disease that affects millions of people each year across the globe. In an effort to find therapies to the many types of cancers, regulation of protein expression through transcription and translation ...