Browsing by Author "Neufer, P. Darrell"
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Alternative splicing of UCP1 by non-cell-autonomous action of PEMT
Johnson, Jordan M.; Verkerke, Anthony R.P.; Maschek, J. Alan; Ferrara, Patrick J.; Lin, Chien-Te; Kew, Kimberly A.; Neufer, P. Darrell; Lodhi, Irfan J.; Cox, James E.; Funai, Katsuhiko (2019-11-08)Phosphatidylethanolamine methyltransferase (PEMT) generates phosphatidylcholine (PC), the most abundant phospholipid in the mitochondria and an important acyl chain donor for cardiolipin (CL) biosynthesis. Mice lacking ... -
Cardioprotective mechanisms targeting thiol redox homeostasis and mitochondrial bioenergetics
Alleman, Rick J. (East Carolina University, 2016-05-03)Coronary heart disease is a leading cause of death in the United States, totaled mostly by deaths associated with myocardial infarction and fatal ventricular arrhythmias. The inability to predict the occurrence of these ... -
Deciphering the impact of fructose metabolism on liver mitochondrial bioenergetics
Buddo, Katherine A (East Carolina University, 2021-12-07)Since its discovery in 1980, the interest in nonalcoholic fatty liver disease, the liver manifestation of metabolic syndrome, has expanded due to the growing impact on the world's health. Commonly characterized by ... -
Diet-Induced Muscle Insulin Resistance Is Associated With Extracellular Matrix Remodeling and Interaction With Integrin αβ in Mice
Kang, Li; Ayala, Julio E.; Lee-Young, Robert S.; Zhang, Zhonghua; James, Freyja D.; Neufer, P. Darrell; Pozzi, Ambra; Zutter, Mary M.; Wasserman, David H. (2011-02) -
Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin α<inf>2</inf>β <inf>1</inf>in mice
Kang, Li; Ayala, Julio E.; Lee-Young, Robert S.; Zhang, Zhonghua; James, Freyja D.; Neufer, P. Darrell; Pozzi, Ambra; Zutter, Mary M.; Wasserman, David H. (2011)OBJECTIVE: The hypothesis that high-fat (HF) feeding causes skeletal muscle extracellular matrix (ECM) remodeling in C57BL/6J mice and that this remodeling contributes to diet-induced muscle insulin resistance (IR) through ... -
Effect of Acute Exercise or Fasting on Mitochondrial Function and High Fat Diet-Induced Insulin Resistance
Kwon, Oh Sung (East Carolina University, 2009)A high-fat diet leads to an accumulation of lipid in skeletal muscle, and the development of both mitochondrial dysfunction and insulin resistance. Recently, our lab reported that lipid overload leads to elevated ... -
Effect of Metformin on the Lifespan and Health Span of Drosophila
Chan, Elizabeth Waynee (East Carolina University, 2023-05-02)Metformin has been the most used drug to treat diabetes for nearly 70 years. It reduces the pressure on the mitochondria from over calorific foods (i.e., fast foods), which termed the Western Diet. Metformin’s ability to ... -
Effects of exercise on obesity-induced mitochondrial dysfunction in skeletal muscle
Heo, Jun-Won; No, Mi-Hyun; Park, Dong-Ho; Kang, Ju-Hee; Seo, Dae Yun; Han, Jin; Neufer, P. Darrell; Kwak, Hyo-Bum (2017-11)Obesity is known to induce inhibition of glucose uptake, reduction of lipid metabolism, and progressive loss of skeletal muscle function, which are all as- sociated with mitochondrial dysfunction in skeletal muscle. ... -
Effects of Insulin Sensitivity Modulators on the Mitochondrial Fate of Oxygen in Skeletal Muscle
Kane, Daniel A. (East Carolina University, 2010)Increasingly, reactive oxygen species (ROS) are implicated in the development of insulin resistance. To test the hypothesis that modulators of insulin sensitivity (i.e., metformin, ovarian sex steroids and exercise training) ... -
The effects of statins on mitochondrial function
Mayo, William Joseph (East Carolina University, 2013)Statins, or 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are among the most commonly prescribed medications in the United States. They are commonly used to treat hypercholesterolemia, a condition ... -
Enhanced Mitochondrial Superoxide Scavenging Does Not Improve Muscle Insulin Action in the High Fat-Fed Mouse
Lark, Daniel Stephen; Kang, Li; Lustig, Mary E.; Bonner, Jeffrey S.; James, Freyja D.; Neufer, P. Darrell; Wasserman, David H. (2015-05)Improving mitochondrial oxidant scavenging may be a viable strategy for the treatment of insulin resistance and diabetes. Mice overexpressing the mitochondrial matrix isoform of superoxide dismutase (sod2tg mice) and/or ... -
ESTABLISHMENT OF THE PYRUVATE DEHYDROGENASE COMPLEX AS A CENTRAL REGULATOR OF MITOCHONDRIAL REDOX WITHIN SKELETAL MUSCLE
Fisher-Wellman, Kelsey H. (East Carolina University, 2013)Once regarded as "byproducts" of aerobic metabolism, the production of superoxide/H₂O₂ is now understood to be a highly specialized and extensively regulated process responsible for exerting control over a vast number of ... -
Estrogen Receptor-α in Female Skeletal Muscle is Not Required for Regulation of Muscle Insulin Sensitivity and Mitochondrial Regulation
McClung, Joseph M.; Iñigo, Melissa R.; Amorese, Adam J.; Tarpey, Michael D.; Balestrieri, Nicholas P.; Jones, Keith G.; Patteson, Daniel J.; Torres, Maria.J.; Lin, Chien-Te; Smith, Cody D.; Heden, Timothy D.; McMillin, Shawna L.; Weyrauch, Luke A.; Stanley, Erin C.; Schmidt, Cameron A.; Funai, Katsuhiko; Gowdy, Kymberly M.; Witczak, Carol A.; Neufer, P. Darrell; Spangenburg, Espen E. (2020-04-01) -
Exercise-Induced Protection Against Reperfusion Arrhythmia Involves Stabilization of Mitochondrial Energetics
Spangenburg, Espen; Alleman, Rick J.; Tsang, Alvin M.; Ryan, Terence E.; Patteson, Daniel J.; McClung, Joseph M.; Shaikh, Saame Raza; Neufer, P. Darrell; Brown, David A. (2016-05-15) -
Extensive Skeletal Muscle Cell Mitochondriopathy Distinguishes Critical Limb Ischemia Patients from Claudicants
McClung, Joseph M.; Ryan, Terence E.; Yamaguchi, Dean J.; Schmidt, Cameron A.; Zeczycki, Tonya N.; Brophy, Patricia; Green, Thomas D.; Tarpey, Michael D.; Karnekar, Reema; Goldberg, Emma J.; Neufer, P. Darrell; Spangenburg, Espen E. (2018-11-02) -
Genetically Increasing Flux Through b-Oxidation in Skeletal Muscle Increases Mitochondrial Reductive Stress and Glucose Intolerance
Smith, Cody D.; Lin, Chien-Te; McMillin, Shawna L.; Weyrauch, Luke A.; Schmidt, Cameron A.; Smith, Cheryl A.; Witczak, Carol; Neufer, P. Darrell; Kurland, Irwin J. (2021) -
Heterozygous SOD2 Deletion Impairs Glucose-Stimulated Insulin Secretion, but Not Insulin Action, in High-Fat–Fed Mice
Kang, Li; Dai, Chunhua; Lustig, Mary E.; Bonner, Jeffrey S.; Mayes, Wesley H.; Mokshagundam, Shilpa; James, Freyja D.; Thompson, Courtney S.; Lin, Chien-Te; Perry, Christopher G.R.; Anderson, Ethan; Neufer, P. Darrell; Wasserman, David H.; Powers, Alvin C. (2014-11) -
Human Studies of Mitochondrial Biology Demonstrate an Overall Lack of Binary Sex Differences: A Multivariate Meta-Analysis
Fisher-Wellman, Kelsey H.; Neufer, P. Darrell; Junker, Alex (2022) -
The Influence of Energy Expenditure on Mitochondrial Functions, Oxidative Stress and Insulin Resistance under Metabolic Oversupply Conditions
Lin, Chien-Te (East Carolina University, 2011)Mitochondrial respiratory capacity and oxidative stress have been implicated in the development of insulin resistance (IR) and type II diabetes. A causative role of mitochondrial oxidative stress in the etiology of ... -
Intrinsic OXPHOS Limitations Underlie Cellular Bioenergetics in Leukemia
Nelson, Margaret AM; McLaughlin, Kelsey L.; Hagen, James T.; Coalson, Hannah S.; Schmidt, Cameron; Kassai, Miki; Kew, Kimberly A.; McClung, Joseph M.; Neufer, P. Darrell (2021)