Browsing by Subject "Cardiomyopathies"
Now showing items 1-3 of 3
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Disrupted Adiponectin-Connexin43 Signaling Underlies Exacerbated Myocardial Dysfunction in Diabetic Female Rats
(East Carolina University, 2019-04-25)The 2015 American Heart Association scientific statement has advocated for sex- specific research to understand the paradoxically higher sensitivity of women to type 2 diabetes mellitus (T2DM)-associated cardiovascular ... -
Role of Dopamine Receptor 3 in Cardiac Fibrosis
(East Carolina University, 2021-12-20)Dopamine receptors are known to exist primarily in the central nervous system and have been extensively studied there. However, other organ systems in the periphery, such as the kidney, have been shown to express these ... -
Some Cardiomyopathy-Causing Troponin I Mutations Stabilize a Functional Intermediate Actin State
(East Carolina University, 2009-03-18)We examined four cardiomyopathy-causing mutations of troponin I that appear to disturb function by altering the distribution of thin filament states. The R193H (mouse) troponin I mutant had greater than normal actin-activated ...