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Impact of Hormone Replacement Therapy on Exercise Training-Induced Improvements in Insulin Action in Sedentary Overweight Adults
(East Carolina University, 2008-07)
Exercise training (ET) and hormone replacement therapy (HRT) are both recognized influences on insulin action, but the influence of HRT on responses to ET has not been examined. In order to determine if HRT use provided ...
Functional Unit of the RNA Polymerase II C-Terminal Domain Lies within Heptapeptide PairsÂ
(East Carolina University, 2004-06)
Unlike all other RNA polymerases, the largest subunit (RPB1) of eukaryotic DNA-dependent RNA polymerase II (RNAP II) has a C-terminal domain (CTD) comprising tandemly repeated heptapeptides with the consensus sequence ...
AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise
(East Carolina UniversityEast Carolina University, 2008-12-15)
5 -AMP-activated protein kinase(AMPK)is a metabolic fuel sensor that monitors cellular energy charge, while the vasculature is important for maintaining cellular energy homeostasis. Mice with muscle-specific inactive AMPK ...
Analyses of domains and domain fusions in human proto-oncogenes
(East Carolina University, 2009-03-17)
Background: Understanding the constituent domains of oncogenes, their origins and their fusions may shed new light about the initiation and the development of cancers. Results: We have developed a computational pipeline ...
Ancient Genome Duplications Did Not Structure the Human Hox-Bearing Chromosomes
(East Carolina University, 2001-05)
The fact that there are four homeobox (Hox) clusters in most vertebrates but only one in invertebrates is often cited as evidence for the hypothesis that two rounds of genome duplication by polyploidization occurred early ...
Bichir HoxA Cluster Sequence Reveals Surprising Trends in Ray-Finned Fish Genomic Evolution
(East Carolina University, 2004-01)
The study of Hox clusters and genes provides insights into the evolution of genomic regulation of development. Derived ray-finned fishes (Actinopterygii, Teleostei) such as zebrafish and pufferfish possess duplicated Hox ...
The AraC-Like Transcriptional Regulator DhbR Is Required for Maximum Expression of the 2,3-Dihydroxybenzoic Acid Biosynthesis Genes in Brucella abortus 2308 in Response to Iron Deprivation
(East Carolina University, 2008-03)
Phenotypic evaluation of isogenic mutants derived from Brucella abortus 2308 indicates that the AlcR homolog DhbR (2,3-dihydroxybenzoic acid [2,3-DHBA] biosynthesis regulator) modulates the expression of the genes involved ...
Physical Activity, Academic Performance, and Physical Self-Description in Adolescent Females
(East Carolina University, 2009)
Despite the many health benefits of being physically active, nearly a quarter of U.S. adults and adolescents report no participation in leisure-time physical activity. It is recommended that children and adolescents ...
The Questions of High School Students with Learning Disabilities About Attending College
(East Carolina University, 2009)
Students with learning disabilities currently comprise the largest number of students with disabilities in the public schools. Despite this, very few of them go on to attend a four-year postsecondary institution. Because ...
Research and Practice in Academic Libraries: A Case Study
(2001)
In recent decades, as academic librarians have achieved tenure-track or even special faculty status, a growing professional consensus has emerged that they should uphold this status by actively engaging in research and ...