Search
Now showing items 121-130 of 144
LOCAL ADMINISTRATION OF CARBON MONOXIDE INHIBITS NEOINTIMA FORMATION IN BALLOON INJURED RAT CAROTID ARTERIES
(2005)
Recent studies indicate that systemic induction of heme oxygenase-1 (HO-1), which oxidatively degrades heme into iron, biliverdin, and carbon monoxide (CO), or adenoviral-mediated gene transfer of HO-1 inhibits neointima ...
DINITROBENZENES STIMULATE ELECTRON FLUX WITHIN NEURONAL NITRIC OXIDE SYNTHASE IN THE ABSENCE OF CALMODULIN
(2011)
Efficient electron transfer and conversion of L-arginine to L-citrulline and nitric oxide
(NO●) by neuronal nitric oxide synthase (nNOS) requires calmodulin (CaM) binding. The
present study focused on electron transfer ...
The “Goldilocks Zone� from a redox perspective—Adaptive vs. deleterious responses to oxidative stress in striated muscle
(2014-09)
Consequences of oxidative stress may be beneficial or detrimental in physiological systems. An organ system's position on the “hormetic curve” is governed by the source and temporality of reactive oxygen species (ROS) ...
Methods for Assessing Mitochondrial Function in Diabetes
(2013-04)
A growing body of research is investigating the potential contribution of mitochondrial function to the etiology of type 2 diabetes. Numerous in vitro, in situ, and in vivo methodologies are available to examine various ...
The influence of the level of physical activity and human development in the quality of life in survivors of stroke
(2011)
Background
The association between physical activity and quality of life in stroke survivors has not been analyzed within a framework related to the human development index. This study aimed to identify differences in ...
MicroRNA-431 regulates axon regeneration in mature sensory neurons by targeting the Wnt antagonist
(2013-10)
MicroRNAs (miRNAs) are small, non-coding RNAs that function as key post-transcriptional regulators in neural development, brain function, and neurological diseases. Growing evidence indicates that miRNAs are also important ...
Biomarkers of Disease and Treatment in Murine and Cynomolgus Models of Chronic Asthma
(2012)
Background
Biomarkers facilitate early detection of disease and measurement of therapeutic efficacy, both at clinical and experimental levels. Recent advances in analytics and disease models allow comprehensive screening ...
Cardioprotective mechanisms targeting thiol redox homeostasis and mitochondrial bioenergetics
(East Carolina University, 2016-05-03)
Coronary heart disease is a leading cause of death in the United States, totaled mostly by deaths associated with myocardial infarction and fatal ventricular arrhythmias. The inability to predict the occurrence of these ...
Phosphodiesterases Regulate BAY 41-2272-Induced VASP Phosphorylation in Vascular Smooth Muscle Cells
(2012-02)
BAY 41-2272 (BAY), a stimulator of soluble guanylyl cyclase, increases cyclic nucleotides and inhibits proliferation of vascular smooth muscle cells (VSMCs). In this study, we elucidated mechanisms of action of BAY in its ...
The significance of mirna pathway in peripheral nerve regeneration following sciatic nerve injury.
(East Carolina University, 2012)
microRNAs (miRNAs) are small (21-23 nucleotides) single-stranded RNAs that play important roles in post-transcriptional regulation of gene expression. The binding of miRNA to its specific target mRNAs at 3' UTR causes ...