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A targeted Coch missense mutation: a knock-in mouse model for DFNA9 late-onset hearing loss and vestibular dysfunction
(East Carolina University, 2008-11-01)
Mutations in COCH (coagulation factor C homology) are etiologic for the late-onset, progressive, sensorineural hearing loss and vestibular dysfunction known as DFNA9. We introduced the G88E mutation by gene targeting into ...
Otoconin-90 Deletion Leads to Imbalance but Normal Hearing: A Comparison with Other Otoconia Mutants
(East Carolina University, 2008-04)
Our sense of gravitation and linear acceleration is mediated by stimulation of vestibular hair cells through displacement of otoconia in the utricle and saccule (the gravity receptor organ). We recently showed that otoconin-90 ...
Osteopontin is not Critical for Otoconia Formation or Balance Function
(East Carolina University, 2008-06)
Unlike the structural and mechanical role of bone crystals, the inertial mass of otoconia crystals provides a shearing force to stimulate the mechanoreceptors of the utricle and saccule (the gravity receptor organ)under ...
Resting Discharge Patterns of Macular Primary Afferents in Otoconia-Deficient Mice
(East Carolina University, 2008-12)
Vestibular primary afferents in the normal mammal are spontaneously active. The consensus hypothesis states that such discharge patterns are independent of stimulation and depend instead on excitation by vestibular hair ...
Priming Anxiety into People who Stutter: Arousal's Influence on Fluency
(East Carolina University, 2008-11)
Many experimental psychologists (Bargh, Chen & Burrows, 1996; Berner & Maier, 2004; Bowers, 1999; Chartrand, VanBaaren & Bargh, 2006; Chen & Haviland-Jones, 2000; Hazlett, Dawson, Schell & Filion, 1990; Macky-Sim & Laing, ...