• Find People
  • Campus Map
  • PiratePort
  • A-Z
    • About
    • Submit
    • Browse
    • Login
    View Item 
    •   ScholarShip Home
    • Dissertations and Theses
    • Dissertations
    • View Item
    •   ScholarShip Home
    • Dissertations and Theses
    • Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of The ScholarShipCommunities & CollectionsDateAuthorsTitlesSubjectsTypeDate SubmittedThis CollectionDateAuthorsTitlesSubjectsTypeDate Submitted

    My Account

    Login

    Statistics

    View Google Analytics Statistics

    THE EFFECT OF SOCIAL EXPERIENCE ON THE SYNERGISTIC NEUROMODULATION OF MOTOR CIRCUITS

    Thumbnail
    View/ Open
    CLEMENTS-DOCTORALDISSERTATION-2022.pdf (42.84Mb)

    Show full item record
    Author
    Clements, Katie N.
    Access
    This item will be available on: 2024-07-01
    Abstract
    Forming social groups is a critical adaptive strategy for the survival of many animal species, where conflict between members can result in dominance relationships. Dominance relationships are often formed through aggressive interactions and influence the cognitive and physiological properties of individuals in a status-dependent manner. The aim of this dissertation is to discern how zebrafish utilize aggression and visual cues to reinforce a stable dominance relationship, and what effect stable dominance has on the neurobiological processes underlying motor behavior, with a focus on dopamine signaling. Dopamine has been implicated in aggression, social regulation, and modulation of motor circuits, making it a central point of study regarding the relationship between social dominance and motor behavior. Using behavioral, pharmacological, and genetic approaches, I have found that (1) in addition to physical aggression, zebrafish alter their stripe coloration intensity to reinforce dominance, (2) stable dominance alters dopamine signaling through decreased expression of the dopamine transporter and the dopamine receptor type-1b, (3) changes in dopamine signaling manifest in altered escape and swimming locomotor behavior, and (4) dopamine acts synergistically with other neurotransmitters to regulate status-dependent motor circuit activation. Results from this dissertation have provided evidence for how stable dominance impacts modulation of motor circuits, revealing how changes in relative excitability of multiple neuromodulatory inputs provide a mechanism for the nervous system to adapt to changes in social conditions and allow animals to select a socially appropriate behavioral response.
    URI
    http://hdl.handle.net/10342/11087
    Subject
    Zebrafish, Dopamine, Mauthner, Social Status
    Date
    2022-07-15
    Citation:
    APA:
    Clements, Katie N.. (July 2022). THE EFFECT OF SOCIAL EXPERIENCE ON THE SYNERGISTIC NEUROMODULATION OF MOTOR CIRCUITS (Doctoral Dissertation, East Carolina University). Retrieved from the Scholarship. (http://hdl.handle.net/10342/11087.)

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Clements, Katie N.. THE EFFECT OF SOCIAL EXPERIENCE ON THE SYNERGISTIC NEUROMODULATION OF MOTOR CIRCUITS. Doctoral Dissertation. East Carolina University, July 2022. The Scholarship. http://hdl.handle.net/10342/11087. September 27, 2023.
    Chicago:
    Clements, Katie N., “THE EFFECT OF SOCIAL EXPERIENCE ON THE SYNERGISTIC NEUROMODULATION OF MOTOR CIRCUITS” (Doctoral Dissertation., East Carolina University, July 2022).
    AMA:
    Clements, Katie N.. THE EFFECT OF SOCIAL EXPERIENCE ON THE SYNERGISTIC NEUROMODULATION OF MOTOR CIRCUITS [Doctoral Dissertation]. Greenville, NC: East Carolina University; July 2022.
    Collections
    • Biology
    • Dissertations
    Publisher
    East Carolina University

    xmlui.ArtifactBrowser.ItemViewer.elsevier_entitlement

    East Carolina University has created ScholarShip, a digital archive for the scholarly output of the ECU community.

    • About
    • Contact Us
    • Send Feedback