RSS 1.0Dissertations and Theses
Recent Submissions
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DEVELOPMENT OF SMALL-MODELCULE INHIGITORS OF THE INTIATING PROTEASES, C1r AND C1s, OF THE CLASSICAL COMPLEMENT PATHWAY
(2019-12)Complement is a proteolytic cascade that upon activation plays a key effector role in the innate immune system and acts to prime the adaptive immune response. During normal homeostatic events, complement is tightly regulated ... -
YIELD STRENGTH OF THE EGADI 10 WARSHIP: USING NONLINEAR COMPUTER SIMULATIONS TO EXAMINE COLLISION DYNAMICS IN GRECO-ROMAN NAVAL CONFLICTS
(2019-12)The study of ancient Mediterranean naval warfare expanded dramatically with the emergence of maritime archaeology and the subsequent discovery of artifacts and ship remains such as the Athlit and Egadi rams. The ship ... -
“LIFE HUNG ON A WORD”: SHIBBOLETHS AND GENOCIDE IN DANTICAT’S THE FARMING OF BONES, WIESEL’S NIGHT, AND COURTEMANCHE’S A SUNDAY AT THE POOL IN KIGALI
(2019-12)This thesis explores how shibboleths, or cultural passwords, function as markers to signify identity and group membership status among coexisting ethnic groups. Specifically, shibboleths are critical for identity detection ... -
A SINGLE-CHAIN GMCSF-MOG TOLEROGENIC VACCINE EXPANDS MOG-SPECIFIC CD25+ FOXP3+ REGULATORY T CELLS THROUGH LOW-EFFICIENCY ANTIGEN RECOGNITION EVENTS TO INHIBIT EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
(2019-12)Previous studies showed that tolerogenic vaccines comprised of single-chain GMCSF-neuroantigen (NAg) fusion proteins inhibited experimental autoimmune encephalomyelitis (EAE) in rodents. The studies detailed here provide ... -
ACTING "WHITE": THE UNSPOKEN, UNDERSTOOD HIERARCHY OF BLACKNESS
(2020-01-09)This thesis will examine how a variety of extenuating factors serve to complicate a black person’s self-identity, as well as determine acceptance or exclusion from the black community in the United States. The introductory ... -
Blood Lactate Predicts Resting Energy Expenditure in Non-Obese Caucasian Females
(East Carolina University, 2019-08-01)Background: Obesity and Type 2 Diabetes are both global epidemics that continue to skyrocket. High basal plasma lactate levels, reduced oxidative capacity, and insulin resistance are co-morbidities with these metabolic ... -
Assessing Pre-service Early Childhood Teachers' Perceived Preparedness on Early Childhood Social-Emotional Competencies and Resources Needed
(East Carolina University, 2019-07-25)The study assessed the perceived preparedness of early childhood pre-service teachers on early childhood social-emotional competencies and the resources they needed to feel competent. Twenty-eight junior and senior pre-service ... -
POSTGRESQL AS A MULTI-MODEL DATABASE
(East Carolina University, 2019-07-26)Data is being generated at unprecedented volume and speed, which is popularly known as Big Data. Most of this data is unstructured and requires natural language processing and information retrieval techniques to extract ... -
Cruising for Plants and Progress: Marian and David Fairchild and the Allison V. Armour Expeditions, 1925-1933
(East Carolina University, 2019-07-23)This thesis examines the Allison V. Armour Expeditions that took place between 1925 and 1933 aboard research vessel Utowana. Led by American botanist David G. Fairchild and sponsored by philanthropist Allison V. Armour, ... -
Archival Document Processing using Cognitive Computing
(East Carolina University, 2019-07-22)The world, as we know it, is constructed in the form of knowledge. Our ancestors have passed their experiences to the next generation over time using handwritten documents. Although these old manuscripts are still available ... -
Performance Analysis of Extractive Text Summarization
(East Carolina University, 2019-07-22)In this era, data is increasing exponentially, and it is crucial for people to keep up with all of this information. The information is available in several different forms such as news articles, online blogs, etc., many ... -
IRON ISOTOPE GEOCHEMISTRY OF BULK ROCKS AND Fe-Ti OXIDES FROM THE SKAERGAARD LAYERED MAFIC INTRUSION, SE GREENLAND
(East Carolina University, 2019-07-23)Small, but significant fractionation of Fe isotopes occurs in high-temperature igneous rocks. Despite increasing study, the exact causes of this fractionation are still debated. Therefore, a systematic study of a complete ... -
The Folkloric Image of the Good Girl and Its Effects on Women in the Age of the Internet
(East Carolina University, 2019-07-19)Folklore is the unofficial culture of a society that changes over time and often reflects what a society finds important. One image of folklore is that of the "good girl." The good girl ideal is the concept that women have ... -
Investigating Novel Chromosome 2 Genetic Variants Associated with Recurrent Stroke
(East Carolina University, 2019-07-18)As the fifth leading cause of death and leading cause of long-term disability, stroke affects 795,000 individuals annually in the United States alone. Recurrent stroke, which is far more deadly and disabling, accounts for ... -
Fine-mapping a novel locus on Chromosome 1 for associations with recurrent stroke
(East Carolina University, 2019-07-18)INTRODUCTION: Stroke is a complex, multifactorial cerebrovascular disease that afflicts millions of individuals both nationally and globally. Of the annual 795,000 stroke incidents, approximately 185,000 are recurrent ... -
NR5A family member ftz-f1 is necessary to promote oocyte development
(East Carolina University, 2019-07-15)Gamete production in mammals and insects is intimately tied to nutrition status. Conversion of nutritionally-dependent physiological signals to molecular mechanisms underlying control of oogenesis, however, remains largely ... -
THE EFFECT OF AMP DEAMINASE 3 DEFICIENCY ON POST-MYOCARDIAL INFARCT FUNCTIONAL AND HISTOLOGICAL OUTCOMES IN MICE
(East Carolina University, 2019-07-17)PURPOSE: Humans deficient in the metabolic enzyme AMP deaminase 3 have improved survival and clinical outcomes in cases of revascularization, myocardial infarction, and/or heart failure. Because of the nature of this ... -
Peroxisome Proliferator-Activated Receptor Gamma Deficiency Promotes a T Lymphocyte Response in a Murine Model of Chronic Pulmonary Sarcoidosis
(East Carolina University, 2019-07-03)Sarcoidosis is a chronic granulomatous disease of unknown etiology. Previous studies from our lab have shown a deficiency of the nuclear transcription factor peroxisome proliferator-activated receptor gamma (PPAR[gamma]) ... -
Measuring and Assessing Food Insecurity Among East Carolina University Undergraduate Students
(East Carolina University, 2019-07-02)Food insecurity has long been an issue nationwide, however, there has been little emphasis placed on food insecurity among college students. This thesis employed a cross-sectional survey of 1,170 randomly selected undergraduate ... -
A metabolomics approach to understanding recurrent stroke risk in African Americans
(East Carolina University, 2019-07-02)Stroke is a significant health burden, as the fifth leading cause of death and the number one cause of serious, long term disability in the United States. Each year 795,000 individuals suffer a stroke; of which 185,000 ...