Dissertations and Theses
Recent Submissions
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Portrait of a Town Called Penny Hill
(1988-05)This written report of creative thesis is an account of the development of a body of work based on the town of Penny Hill, North Carolina. This report conveys a poetical impression of the intimate spaces of the ... -
The Unwelcoming Home: Telecommuting and its Influence on Workplace Incivility
(East Carolina University, 2024-01-19)With the occurrence of recent events, the workplaces of many corporations have experienced a major shift into the virtual realm. The formation of online meetings and increased email communication has created an exemplary ... -
UNDERSTANDING THE ROLE OF RAB10 IN NEURONAL RESILIENCE
(East Carolina University, 2023-12-08)Neuroresilience refers to the remarkable capacity of the brain to maintain its normal functioning and safeguard against cognitive decline even in the face of stress or trauma. The exploration of genes and pathways that ... -
PSYCHOLOGICAL IMPACT OF PROSTHETIC JOINT INFECTIONS FOLLOWING TOTAL HIP AND KNEE REPLACEMENT
(East Carolina University, 2023-12-06)Background. Prosthetic Joint Infection (PJI) is a devastating complication of total joint arthroplasty (TJA) with a relative survival rate worse than that of prostate cancer, melanoma, and breast cancer. This study explores ... -
A Multi-Compartmental Investigation of Bcl-2 Associated Athanogene 3 (BAG3) in Peripheral Artery Disease
(East Carolina University, 2023-12-13)Peripheral artery disease (PAD) is caused by an atherosclerotic blockage to a vessel that restricts blood flow to the lower extremity. Chronic limb threatening ischemia (CLTI) is the most severe manifestation of PAD, and ... -
MODULATING MMP-9 SUBSTRATE PREFERENCE TO REDUCE INFLAMMATION POST-MI
(East Carolina University, 2023-12-08)Worldwide, the prevalence of cardiovascular disease (CVD) is escalating, with myocardial infarction (MI) significantly contributing to the heightened rates of morbidity and mortality. Notably, one in every four MI patients ... -
DEFINING THE ABILITY OF SNAT NANOTHERAPEUTIC TO INHIBIT SARS-COV-2 INFECTION AND ALTER THE HOST MICRONOME TO INDUCE AN ANTIVIRAL CELLULAR ENVIRONMENT
(East Carolina University, 2023-12-07)MicroRNAs (miRNAs) are regulatory elements that canonically bind to target mRNAs, reducing translation and protein output. They are non-coding strands of RNA, roughly 18-25 nucleotides long, and are found in plants, animals, ... -
Identification of galectin-1 as a marker for claudin-low breast cancer and implications for tumor progression
(East Carolina University, 2024-01-04)Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer. Patients with TNBC have a high rate of metastasis and mortality due to the lack of targeted therapies and resistance to chemotherapy. This ... -
STUDENT TRAJECTORIES RELATED TO READING AND ATTENTION SKILLS: IS THERE EVIDENCE OF THE MATTHEW EFFECT?
(East Carolina University, 2024-01-04)Research on reading is widespread given its predictive nature for adult outcomes pertaining to success, such as high school graduation, college entrance, health literacy, employment status and wages earned. Research focusing ... -
Characterizing the Binding of Toxic and Essential Metals to EF-Hand Peptides III and IV of Human Cardiac Troponin C Using Fluorescence Spectroscopy and Isothermal Titration Calorimetry
(East Carolina University, 2023-12-05)Cadmium is one of the most toxic natural and anthropogenic metals found in our environment. Exposure to cadmium is associated with several cardiovascular conditions, neurodegenerative disorders, and cancers. Cadmium’s ... -
BOREOUT, EMPLOYEE WELL-BEING, AND THE POTENTIAL MODERATION BY PSYCHOLOGICAL CAPITAL
(East Carolina University, 2023-12-04)Employee well-being is an important determining factor that contributes to employee resilience (Tonkin, Malinen, Naswall, & Kuntz, 2018) and productivity (Baptiste, 2008), which ultimately plays a vital role in an ... -
Genetic deletion of skeletal muscle Cox6a2 (Cytochrome C Oxidase Subunit 6a polypeptide 2) delays regeneration in preclinical model of Peripheral Artery Disease
(East Carolina University, 2023-12-04)Chronic limb threatening ischemia (CLTI) is the most severe clinical manifestation of peripheral artery disease (PAD). There are no current therapeutic options for CLTI outside of surgical intervention and it remains the ... -
A Small Sentiment and Other Stories
(East Carolina University, 2023-12-06)Herein lies a collection of three short stories. They are thematically connected by an over-arching exploration of the intricacies of interpersonal relationships. The final two stories are also thematically similar in their ... -
The importance of land use on public health. Case studies from the Rivanna River Watershed.
(East Carolina University, 2023-12-11)Introduction: Safe and reliable water is vital to sustaining the environment and human health. However, factors including an expanding population, aging infrastructure, climate change, emerging contaminants, nonpoint source ... -
NITROGEN AND BACTERIA TREATMENT EFFICIENCY OF ONSITE WASTEWATER SYSTEMS IN THE PIEDMONT OF NORTH CAROLINA
(East Carolina University, 2023-12-01)Onsite wastewater treatment systems (OWTSs) are commonly used in rural areas for wastewater disposal. These systems can contribute elevated concentrations of nutrients and bacteria into water resources, resulting in potential ... -
Addressing Rising Hospital Acquired Infections (HAIs) Using Novel Nanotechnology: Implications for Public Health Protection
(East Carolina University, 2023-12-11)Globally rising antibiotic-resistant (AR) and multi-drug resistant (MDR) bacterial infections are of public health concern due to lower efficacy of current antibiotic therapy. Specifically, Hospital Acquired Infections ... -
HUMAN HEALTH EFFECTS OF LEAD IN THE ENVIRONMENT: A MULTI-SOURCE APPROACH OF ELEVATED LEAD EXPOSURE AMONG AT-RISK POPULATIONS IN PITT COUNTY, NORTH CAROLINA, USA
(East Carolina University, 2023-12-05)Despite lead (Pb) in public drinking water has been studied extensively, Pb in homes has received less attention. Elevated Pb level in homes is a growing public health concern as Pb exposure in children is known to cause ... -
ANALYSIS OF COMMUNITY HEALTH WORKER’S SELF-DEFINED ATTITUDE, BEHAVIOR, AND EXPERIENCE REGARDING INTERPROFESSIONAL COLLABORATION
(East Carolina University, 2023-11-30)Evidence suggests that the role of community health workers (CHWs) continues to evolve in support of the demand to address social determinants of health, prevention, cost, and population health. The aim of this mixed-methods ... -
FEEDING KNOWLEDGE AND FEEDING CONFIDENCE OF PROFESSIONAL GROUPS IN EASTERN NORTH CAROLINA WHO ARE INVOLVED IN PROVIDING PRENATAL CARE VISITS FOR PARENTS HAVING A BABY DIAGNOSED WITH CLEFT LIP WITH OR WITHOUT CLEFT PALATE
(East Carolina University, 2023-11-29)Objective: This study aimed to evaluate the feeding knowledge and feeding confidence of different professional groups in eastern North Carolina who provided prenatal care visits (PNVs) for parents having a baby diagnosed ... -
Investigating the genetic basis of aposematic coloration in poison frogs
(East Carolina University, 2023-11-29)Aposematic organisms rely on their conspicuous appearance to signal that they are defended and unpalatable. Such phenotypes are strongly tied to survival and reproduction. Aposematic colors and patterns are highly variable; ...