AZULENE/ALDEHYDE ASSOCIATION: AN ANALOG FOR DAMAGED DNA DETECTION
Author
Shields, Agne A
Abstract
Loss of a nucleic acid base from DNA can leave behind a reactive aldehyde group on ribose. To detect the presence of such “abasic sites,” ethyl-2-aminoazulene-1-carboxylate, a novel azulene-based analog of guanine/adenine, was synthesized. Valeraldehyde was chosen as a simple model for an abasic site. 1H NMR kinetics studies with ethyl-2-aminoazulene-1-carboxylate and valeraldehyde show that this is a slow reaction and suggest that it is zero-order with respect to valeraldehyde. This is consistent with a complex mechanism.
Subject
Date
2022-12-14
Citation:
APA:
Shields, Agne A.
(December 2022).
AZULENE/ALDEHYDE ASSOCIATION: AN ANALOG FOR DAMAGED DNA DETECTION
(Honors Thesis, East Carolina University). Retrieved from the Scholarship.
(http://hdl.handle.net/10342/12366.)
MLA:
Shields, Agne A.
AZULENE/ALDEHYDE ASSOCIATION: AN ANALOG FOR DAMAGED DNA DETECTION.
Honors Thesis. East Carolina University,
December 2022. The Scholarship.
http://hdl.handle.net/10342/12366.
April 19, 2024.
Chicago:
Shields, Agne A,
“AZULENE/ALDEHYDE ASSOCIATION: AN ANALOG FOR DAMAGED DNA DETECTION”
(Honors Thesis., East Carolina University,
December 2022).
AMA:
Shields, Agne A.
AZULENE/ALDEHYDE ASSOCIATION: AN ANALOG FOR DAMAGED DNA DETECTION
[Honors Thesis]. Greenville, NC: East Carolina University;
December 2022.
Collections
Publisher
East Carolina University