• Find People
  • Campus Map
  • PiratePort
  • A-Z
    • About
    • Submit
    • Browse
    • Login
    View Item 
    •   ScholarShip Home
    • ECU Main Campus
    • College of Health and Human Performance
    • Kinesiology
    • View Item
    •   ScholarShip Home
    • ECU Main Campus
    • College of Health and Human Performance
    • Kinesiology
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of The ScholarShipCommunities & CollectionsDateAuthorsTitlesSubjectsTypeDate SubmittedThis CollectionDateAuthorsTitlesSubjectsTypeDate Submitted

    My Account

    Login

    Statistics

    View Google Analytics Statistics

    Effect of Duodenal-Jejunal Bypass on Skeletal Muscle Insulin Signaling in Goto-Kakizaki Rats

    Thumbnail
    View/ Open
    SloanIII_ecu_0600M_10030.pdf (1.415Mb)

    Show full item record
    Author
    Sloan, Ruben Carnell
    Abstract
    Gastric bypass surgery (RYGBP) for the treatment of obesity has proven to clinically reverse type 2 diabetes mellitus. RYGBP involves both gastric reduction and bypass of the proximal small intestine. Duodenal-Jejunal Bypass (DJB) is a surgical procedure that bypasses the proximal small intestine without gastric reduction and has been shown to improve oral glucose tolerance in Goto-Kakizaki (GK) rats, a non-obese animal model of T2DM. We hypothesized that DJB may improve oral glucose tolerance in GK rats by improving insulin signaling in skeletal muscle, the main depot for insulin stimulated glucose uptake. DJB was performed on male 10-12 week old GK rats (GK-DJB), and sham operations were performed on GK rats (GK-Sham). Insulin stimulated IRS-1, phospho-serine 307 of IRS-1, Akt, and phospho-Akt were determined using Western blot. Phospho-Akt was significantly higher in GK-DJB when compared to GK-Sham in soleus and tended to be higher in gastrocnemius (p=0.107). Akt was significantly higher in GK-DJB when compared to GK-Sham in gastrocnemius and tended to be higher in soleus (p=0.074). Phospho-serine 307 of IRS-1 and total IRS-1 were not different between GK-DJB and GK-Sham in gastrocnemius. In conclusion, bypassing the proximal small intestine (DJB) improves components of skeletal muscle insulin signaling in GK rats, providing mechanistic evidence for the improvement in oral glucose tolerance associated with DJB.  
    URI
    http://hdl.handle.net/10342/1893
    Subject
     Biology, Physiology; Health Sciences, Medicine and Surgery; Biology, Molecular; Physiology; Molecular biology 
    Date
    2009
    Citation:
    APA:
    Sloan, Ruben Carnell. (January 2009). Effect of Duodenal-Jejunal Bypass on Skeletal Muscle Insulin Signaling in Goto-Kakizaki Rats (Master's Thesis, East Carolina University). Retrieved from the Scholarship. (http://hdl.handle.net/10342/1893.)

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Sloan, Ruben Carnell. Effect of Duodenal-Jejunal Bypass on Skeletal Muscle Insulin Signaling in Goto-Kakizaki Rats. Master's Thesis. East Carolina University, January 2009. The Scholarship. http://hdl.handle.net/10342/1893. September 23, 2023.
    Chicago:
    Sloan, Ruben Carnell, “Effect of Duodenal-Jejunal Bypass on Skeletal Muscle Insulin Signaling in Goto-Kakizaki Rats” (Master's Thesis., East Carolina University, January 2009).
    AMA:
    Sloan, Ruben Carnell. Effect of Duodenal-Jejunal Bypass on Skeletal Muscle Insulin Signaling in Goto-Kakizaki Rats [Master's Thesis]. Greenville, NC: East Carolina University; January 2009.
    Collections
    • Kinesiology
    • Master's Theses
    Publisher
    East Carolina University

    xmlui.ArtifactBrowser.ItemViewer.elsevier_entitlement

    East Carolina University has created ScholarShip, a digital archive for the scholarly output of the ECU community.

    • About
    • Contact Us
    • Send Feedback