Increasingly, reactive oxygen species (ROS) are implicated in the development of insulin resistance. To test the hypothesis that modulators of insulin sensitivity (i.e., metformin, ovarian sex steroids and exercise training) ...

Energy balance is considered a fundamental requirement of life forms from single cell organisms to higher mammals such as humans. Unfortunately, our species has also discovered the detrimental metabolic responses to excess ...

Obesity is the result of excess energy storage due to an imbalance between energy storage and energy utilization. Excess energy is stored as triacylglycerol (TAG) in adipose tissue in various regions throughout the body. ...

Interactions between and within organ systems such as skeletal muscle (SkM) and adipose tissue (AT), via immune cell signaling factors (cytokines), may regulate the development of obesity. The increased expression and ...

Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle by Lance M. Bollinger November, 2013 Director of Thesis/Dissertation: Jeffrey J. Brault Major Department: Kinesiology ...

Obese individuals exhibit skeletal muscle metabolic inflexibility by failing to increase fat oxidation and genes linked with mitochondrial biogenesis in response to a high-fat diet (HFD) and lipid incubation in cell culture. ...

Hamstring strains have been shown to occur more often in the long head of the biceps femoris (BFLH) than the semitendinosus and semimembranosus, with most injuries occurring in the proximal half of the BFLH. Muscle modeling ...

Premenopausal women demonstrate preferential accumulation of adiposity in the gynoid region, a distribution which shifts towards the abdominal region after the menopausal transition. Although estrogen is implicated as a ...

Statins, or 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are among the most commonly prescribed medications in the United States. They are commonly used to treat hypercholesterolemia, a condition ...

Once regarded as "byproducts" of aerobic metabolism, the production of superoxide/H₂O₂ is now understood to be a highly specialized and extensively regulated process responsible for exerting control over a vast number of ...