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    HuR involvement in mitotic clonal expansion during acquisition of the adipocyte phenotype

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    Author
    Karschner, Vesna Ann; Pekala, Phillip H.
    Abstract
    In the nucleus HuR binds to mRNAs containing adenylate-uridylate rich elements in the 3?- untranslated region. HuR may influence expression of its ligand mRNA through regulation of polyadenylation, translocation of the message to the cytosol, stabilization of the mRNA and/or altering its translational efficiency. Suppression of HuR using siRNA resulted in an attenuation of the 3T3-L1 differentiation program, consistent with HuR control of the expression of mRNA ligand (s) critical to the differentiation process. In the current study we begin to identify mRNA ligands of HuR whose regulated expression is necessary for adipogenesis. Originally published in Biochemical and Biophysiological Research Communications Vol. 383, No. 2 2009.
    URI
    http://hdl.handle.net/10342/3026
    Subject
     Adipogenisis; Differentiation; 3T3-L1; HuR; Elav; SiRNA; β-actin; p53; [Beta]-actin 
    Date
    2009-05-29
    Citation:
    APA:
    Karschner, Vesna Ann, & Pekala, Phillip H.. (May 2009). HuR involvement in mitotic clonal expansion during acquisition of the adipocyte phenotype. Biochemical and Biophysical Research Communications, (383:2), p.203-205. Retrieved from http://hdl.handle.net/10342/3026

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Karschner, Vesna Ann, and Pekala, Phillip H.. "HuR involvement in mitotic clonal expansion during acquisition of the adipocyte phenotype". Biochemical and Biophysical Research Communications. 383:2. (203-205.), May 2009. March 07, 2021. http://hdl.handle.net/10342/3026.
    Chicago:
    Karschner, Vesna Ann and Pekala, Phillip H., "HuR involvement in mitotic clonal expansion during acquisition of the adipocyte phenotype," Biochemical and Biophysical Research Communications 383, no. 2 (May 2009), http://hdl.handle.net/10342/3026 (accessed March 07, 2021).
    AMA:
    Karschner, Vesna Ann, Pekala, Phillip H.. HuR involvement in mitotic clonal expansion during acquisition of the adipocyte phenotype. Biochemical and Biophysical Research Communications. May 2009; 383(2) 203-205. http://hdl.handle.net/10342/3026. Accessed March 07, 2021.
    Collections
    • Biochemistry and Molecular Biology
    Publisher
    East Carolina University

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