HuR involvement in mitotic clonal expansion during acquisition of the adipocyte phenotype

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Author
Karschner, Vesna Ann; Pekala, Phillip H.
Abstract
In the nucleus HuR binds to mRNAs containing adenylate-uridylate rich elements in the 3?- untranslated region. HuR may influence expression of its ligand mRNA through regulation of polyadenylation, translocation of the message to the cytosol, stabilization of the mRNA and/or altering its translational efficiency. Suppression of HuR using siRNA resulted in an attenuation of the 3T3-L1 differentiation program, consistent with HuR control of the expression of mRNA ligand (s) critical to the differentiation process. In the current study we begin to identify mRNA ligands of HuR whose regulated expression is necessary for adipogenesis. Originally published in Biochemical and Biophysiological Research Communications Vol. 383, No. 2 2009.
URI
http://hdl.handle.net/10342/3026
Subject
 Adipogenisis; Differentiation; 3T3-L1; HuR; Elav; SiRNA; β-actin; p53; [Beta]-actin 
Date
2009-05-29
Citation:
APA:
Karschner, Vesna Ann, & Pekala, Phillip H.. (May 2009). HuR involvement in mitotic clonal expansion during acquisition of the adipocyte phenotype. Biochemical and Biophysical Research Communications, (383:2), p.203-205. Retrieved from http://hdl.handle.net/10342/3026

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MLA:
Karschner, Vesna Ann, and Pekala, Phillip H.. "HuR involvement in mitotic clonal expansion during acquisition of the adipocyte phenotype". Biochemical and Biophysical Research Communications. 383:2. (203-205.), May 2009. October 26, 2020. http://hdl.handle.net/10342/3026.
Chicago:
Karschner, Vesna Ann and Pekala, Phillip H., "HuR involvement in mitotic clonal expansion during acquisition of the adipocyte phenotype," Biochemical and Biophysical Research Communications 383, no. 2 (May 2009), http://hdl.handle.net/10342/3026 (accessed October 26, 2020).
AMA:
Karschner, Vesna Ann, Pekala, Phillip H.. HuR involvement in mitotic clonal expansion during acquisition of the adipocyte phenotype. Biochemical and Biophysical Research Communications. May 2009; 383(2) 203-205. http://hdl.handle.net/10342/3026. Accessed October 26, 2020.
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Publisher
East Carolina University