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Effect of North American Ginseng on 137Cs-induced Micronuclei in Human Lymphocytes

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Authors

Lee, Tung-Kwang
Wang, Weidong
O'Brien, Kevin F.
Roberta, Johnke
Allison, Ron R.
Diaz, Angelica
Wang, Tao

Journal Title

Journal ISSN

Volume Title

Publisher

East Carolina University

Abstract

To explore the radioprotective effect of a standardized North American ginseng extract (NAGE) on human peripheral blood lymphocytes (PBL), a micronuclei (MN) assay was conducted in PBL obtained from 12 volunteers. NAGE (50â 1000 µg/mL) and WR-1065 (1 mm and 3 mm) were applied to PBL cultures at 0 h and 90 min post-irradiation. It was found that (1) the baseline MN yield of PBL ranged from 14.4 ± 1.5 to 15.9 ± 1.5 per 1000 binucleated cells (p > 0.05); after irradiation (1 Gy and 2 Gy), the MN yield increased sharply; (2) MN yields declined with increasing concentrations of NAGE and WR-1065. Even at 90 min post-irradiation of 1 Gy, the maximum level of MN reduction rate caused by NAGE and WR-1065 was 53.8% and 59.2%, respectively; after 2 Gy irradiation, it was 37.3% and 42%, respectively; (3) the MN distribution in PBL followed a non-Poisson distribution in all cases; and (4) both NAGE and WR-1065 showed no significant effect on the proliferation index of lymphocytes. The results indicate that NAGE is a relatively non-toxic natural product, which can be administered as a dietary supplement and has the potential to be a radiation countermeasure. Originally published Phytotherapy Research Vol. 22, No. 12 2008.

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Citation

Phytotherapy Research; 22:12 p. 1614-1622

item.page.doi

10.1002/ptr.2533

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