• Find People
  • Campus Map
  • PiratePort
  • A-Z
    • About
    • Submit
    • Browse
    • Login
    View Item 
    •   ScholarShip Home
    • Health Sciences Campus
    • Brody School of Medicine
    • Oncology
    • View Item
    •   ScholarShip Home
    • Health Sciences Campus
    • Brody School of Medicine
    • Oncology
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of The ScholarShipCommunities & CollectionsDateAuthorsTitlesSubjectsTypeDate SubmittedThis CollectionDateAuthorsTitlesSubjectsTypeDate Submitted

    My Account

    Login

    Statistics

    View Google Analytics Statistics

    Radioprotective Effect of American Ginseng on Human Lymphocytes at 90 Minutes Post-irradiation: A Study of 40 Cases

    Thumbnail
    View/ Open
    RadioprotectAmGinsengLymphocytesLeeetal.pdf (309.4Kb)

    Show full item record
    Author
    Lee, Tung-Kwang; O'Brien, Kevin F.; Wang, Weidong; Johnke, Roberta M.; Sheng, Chao; Benhabib, Sidi Mohammed; Wang, Tao; Allison, Ron R.
    Abstract
    Backgroundâ Ionizing radiation (IR) initiates intracellular oxidative stress through enhanced formation of reactive oxygen species (ROS) that attack DNA leading to cell death. As the diversity of IR applied in medicine, agriculture, industry, and the growing threats of global terrorism, the acquisition of radioprotectors is an urgent need for the nation. However, the applicability of radioprotectors currently under investigation is limited due to their inherent toxicity. Objectiveâ This study investigated the effect of a standardized North American ginseng extract (NAGE, total ginsenoside content: 11.7%) on DNA damage in human lymphocytes at 90 min postirradiation. Designâ With the application of NAGE (250 â 1000 μg mlâ 1) at 90 min post-irradiation (1 and 2 Gy), DNA damage in lymphocytes obtained from 40 healthy individuals was evaluated by cytokinesis-block micronucleus (CBMN) assay. Similar experiments were also performed in lymphocytes treated with WR-1065 (1 mM or 3mM). In addition, before and after irradiation, lymphocytes obtained from 10 individuals were measured for their total antioxidant capacity (TAC) and the reactive oxygen species (ROS). Resultsâ The significant effect of NAGE against 137Cs-induced MN in lymphocytes is concentration-dependent. NAGE (750 μg mlâ 1) reduced MN yield by 50.7% after 1 Gy and 35.9% after 2 Gy exposures, respectively; these results were comparable to that of WR-1065. Further, we also found that NAGE reduces MN yield and ROS but increases TAC in lymphocytes. Conclusionsâ Our results suggest that NAGE is a relatively non-toxic natural compound that holds radioprotective potential in human lymphocytes even when applied at 90 min post-irradiation. One of the radioprotective mechanisms may be mediated through the scavenging of free radicals and enhancement of the intracellular TAC. Originally published Journal of Alternative and Complementary Medicine Vol. 16, No. 5 2010.
    URI
    http://hdl.handle.net/10342/3039
    Subject
     American ginseng; Radiation; Micronuclei; Lymphocytes; Oxidative stress; WR-1065 
    Date
    2010-05
    Citation:
    APA:
    Lee, Tung-Kwang, & O'Brien, Kevin F., & Wang, Weidong, & Johnke, Roberta M., & Sheng, Chao, & Benhabib, Sidi Mohammed, & Wang, Tao, & Allison, Ron R.. (May 2010). Radioprotective Effect of American Ginseng on Human Lymphocytes at 90 Minutes Post-irradiation: A Study of 40 Cases. Journal of Alternative and Complementary Medicine, 16(5), 561- 567. Retrieved from http://hdl.handle.net/10342/3039

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Lee, Tung-Kwang, and O'Brien, Kevin F., and Wang, Weidong, and Johnke, Roberta M., and Sheng, Chao, and Benhabib, Sidi Mohammed, and Wang, Tao, and Allison, Ron R.. "Radioprotective Effect of American Ginseng on Human Lymphocytes at 90 Minutes Post-irradiation: A Study of 40 Cases". Journal of Alternative and Complementary Medicine. 16:5. (561-567), May 2010. September 21, 2023. http://hdl.handle.net/10342/3039.
    Chicago:
    Lee, Tung-Kwang and O'Brien, Kevin F. and Wang, Weidong and Johnke, Roberta M. and Sheng, Chao and Benhabib, Sidi Mohammed and Wang, Tao and Allison, Ron R., "Radioprotective Effect of American Ginseng on Human Lymphocytes at 90 Minutes Post-irradiation: A Study of 40 Cases," Journal of Alternative and Complementary Medicine 16, no. 5 (May 2010), http://hdl.handle.net/10342/3039 (accessed September 21, 2023).
    AMA:
    Lee, Tung-Kwang, O'Brien, Kevin F., Wang, Weidong, Johnke, Roberta M., Sheng, Chao, Benhabib, Sidi Mohammed, Wang, Tao, Allison, Ron R.. Radioprotective Effect of American Ginseng on Human Lymphocytes at 90 Minutes Post-irradiation: A Study of 40 Cases. Journal of Alternative and Complementary Medicine. May 2010; 16(5): 561-567. http://hdl.handle.net/10342/3039. Accessed September 21, 2023.
    Collections
    • Oncology
    Publisher
    East Carolina University

    xmlui.ArtifactBrowser.ItemViewer.elsevier_entitlement

    East Carolina University has created ScholarShip, a digital archive for the scholarly output of the ECU community.

    • About
    • Contact Us
    • Send Feedback