Browsing Kinesiology by Subject "Chemistry, Biochemistry"
Now showing items 1-5 of 5
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Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle
(East Carolina University, 2013)Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle by Lance M. Bollinger November, 2013 Director of Thesis/Dissertation: Jeffrey J. Brault Major Department: Kinesiology ... -
ESTABLISHMENT OF THE PYRUVATE DEHYDROGENASE COMPLEX AS A CENTRAL REGULATOR OF MITOCHONDRIAL REDOX WITHIN SKELETAL MUSCLE
(East Carolina University, 2013)Once regarded as "byproducts" of aerobic metabolism, the production of superoxide/H₂O₂ is now understood to be a highly specialized and extensively regulated process responsible for exerting control over a vast number of ... -
The Influence of Energy Expenditure on Mitochondrial Functions, Oxidative Stress and Insulin Resistance under Metabolic Oversupply Conditions
(East Carolina University, 2011)Mitochondrial respiratory capacity and oxidative stress have been implicated in the development of insulin resistance (IR) and type II diabetes. A causative role of mitochondrial oxidative stress in the etiology of ... -
Metabolic Inflexibility in Response to Lipid Oversupply with Obesity: Epigenetic Modifications Play a Role
(East Carolina University, 2013)The ability to adjust substrate oxidation according to nutrient availability has been termed `metabolic flexibility' and is a critical factor in overall metabolic health. In respect to fatty acid oxidation (FAO) metabolic ... -
Paired Effects of Dietary Leucine Supplementation and Overload on Protein Translational Signaling and Hypertrophy in Aged Rat Skeletal Muscle
(East Carolina University, 2012)Sarcopenia is an age-associated disorder that causes loss of skeletal muscle mass, particularly in type II (fast-twitch) muscle fibers. This loss in muscle mass can cause disability, reductions in the quality of life, and ...