Browsing Kinesiology by Type"Doctoral Dissertation"
Now showing items 1-20 of 41
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Adaptations of the Hypothalamic Arcuate Nucleus in Response to Exercise and Hunger
(East Carolina University, 2018-05-02)The arcuate nucleus of the hypothalamus serves as a critical node for regulation of mammalian energy balance with the ability to sense the status of many organ systems and exert control over effector arms that potently ... -
Alterations in insulin action and contraction-mediated metabolism in myotubes derived from Roux-en-Y gastric bypass patients
(5/16/2016)Roux-en-Y gastric bypass (RYGB) surgery induces various metabolic benefits in severely obese (BMI> 40 kg/m2) individuals, including improved insulin action in peripheral tissues, most notably skeletal muscle, and remission ... -
AMP Deaminase 3 in Skeletal Muscle Atrophy: Regulation of Protein Degradation and Contractile Performance
(East Carolina University, 2015-11-23)Skeletal muscle atrophy is characterized by depressed cellular energetics, increased rates of protein degradation, contractile deficits and loss of muscle mass. A potential regulator of these impairments is the metabolic ... -
Central α-Klotho is a Novel Regulator of Arcuate Neurons and Peripheral Metabolism
(East Carolina University, 2021-04-20)The arcuate nucleus of the hypothalamus (ARC) is a critical nexus of neuron populations that interpret peripheral signals of energy status and deliver diverse efferent outputs to metabolically active tissues. These neurons ... -
Characterization of the glucose transport mechanism responsible for mechanical overload- and acute injury-stimulated skeletal muscle glucose uptake
(East Carolina University, 2022-06-24)Skeletal muscle is a highly adaptable tissue. In response to stimuli such as resistance exercise training or trauma/injury, muscle glucose uptake is stimulated to fuel the energetic and biosynthetic demands of growth, ... -
Characterization of the glucose transport mechanism responsible for mechanical overload- and acute injury-stimulated skeletal muscle glucose uptake
(East Carolina University, 2022-06-24)Skeletal muscle is a highly adaptable tissue. In response to stimuli such as resistance exercise training or trauma/injury, muscle glucose uptake is stimulated to fuel the energetic and biosynthetic demands of growth, ... -
Characterization of the glucose transporters responsible for mechanical overloadstimulated glucose uptake in mouse skeletal muscle
(East Carolina University, 8/5/2020)Resistance exercise training is a recommended form of physical activity for people with type 2 diabetes due to its ability to increase skeletal muscle glucose uptake. Understanding how resistance training controls muscle ... -
THE EFFECT OF CONTRACTILE ACTIVITY AND SUBSTRATE CHALLENGES ON METABOLIC FLEXIBILITY IN HUMAN PRIMARY MYOTUBES
(East Carolina University, 2013)The skeletal muscle of severely obese individuals (BMI > 40 kg/m²) is characterized by a depressed ability to oxidize fatty acids and a failure to upregulate fatty acid oxidation (FAO) in response to increased lipid ... -
Effects of a high fat diet and/or overload on striated muscle structure, function, or metabolism
(East Carolina University, 2020-12-03)Consumption of a high fat diet combined with physical inactivity is associated with many adverse health effects including obesity, insulin resistance/type 2 diabetes, and cardiovascular disease/myocardial infarction. The ... -
Effects of aerobic exercise training on arterial stiffness and autonomic function in obese adults at-risk of cardiovascular disease and type 2 diabetes
(East Carolina University, 8/5/2020)Obesity is a major risk factor for cardiovascular disease (CVD), CVD mortality, and type 2 diabetes. Arterial stiffness and autonomic dysfunction are independent predictors of CVD and type 2 diabetes. Moreover, African ... -
Effects of Exercise Training on Subcutaneous Adipose Tissue in Obese Humans
(East Carolina University, 2017-12-12)Subcutaneous adipose tissue (SAT) is a dynamic organ that has a tremendous ability to remodel in the face of increased energy intake. In obesity, alterations to SAT may lead to metabolic dysfunction and increased risk for ... -
Effects of Insulin Sensitivity Modulators on the Mitochondrial Fate of Oxygen in Skeletal Muscle
(East Carolina University, 2010)Increasingly, reactive oxygen species (ROS) are implicated in the development of insulin resistance. To test the hypothesis that modulators of insulin sensitivity (i.e., metformin, ovarian sex steroids and exercise training) ... -
Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle
(East Carolina University, 2013)Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle by Lance M. Bollinger November, 2013 Director of Thesis/Dissertation: Jeffrey J. Brault Major Department: Kinesiology ... -
Effects of resveratrol and contractile activity in human skeletal muscle myotubes from severely obese individuals
(East Carolina University, 2016-07-25)The prevalence of obesity is exponentially increasing worldwide. Although strategies such as exercise, nutritional intervention, and pharmaceutical therapies including resveratrol have been extensively studied in lean or ... -
ELUCIDATION ON THE MECHANISM OF CAMKKα AS A PRO-GROWTH KINASE IN MOUSE SKELETAL MUSCLE
(East Carolina University, 2016-12-15)Type 2 diabetes affects ~25 million people in the U.S., and is the primary cause of non-traumatic lower limb amputation and the leading cause of blindness in adults. Major risk factors for the development of type 2 diabetes ... -
ESTABLISHMENT OF THE PYRUVATE DEHYDROGENASE COMPLEX AS A CENTRAL REGULATOR OF MITOCHONDRIAL REDOX WITHIN SKELETAL MUSCLE
(East Carolina University, 2013)Once regarded as "byproducts" of aerobic metabolism, the production of superoxide/H₂O₂ is now understood to be a highly specialized and extensively regulated process responsible for exerting control over a vast number of ... -
EXAMINING THE RELATIONSHIPS BETWEEN SHOULDER AND ELBOW SOFT-TISSUE PROPERTIES, THROWING MECHANICS, AND RANGE OF MOTION IN ADULT BASEBALL PITCHERS
(East Carolina University, 8/5/2020)Overhead throwing places extremely high loads on soft-tissue structures of the shoulder and elbow, causing pitchers to be injured at an alarming rate. Most researchers believe soft-tissue injuries in pitchers are acute ... -
IL-15 : A NOVEL REGULATOR OF LIPOLYSIS IN HUMANS?
(East Carolina University, 2014)Interactions between and within organ systems such as skeletal muscle (SkM) and adipose tissue (AT), via immune cell signaling factors (cytokines), may regulate the development of obesity. The increased expression and ... -
Impact of Muscle Material Properties on the Hypertrophic Response of Aged Women to Resistance Exercise
(East Carolina University, 2016-07-21)All of the reports that comprise this dissertation center around the overarching hypothesis that the attenuated response to resistance exercise observed in older adults is caused by an impaired ability of the muscle to ... -
The Influence of Energy Expenditure on Mitochondrial Functions, Oxidative Stress and Insulin Resistance under Metabolic Oversupply Conditions
(East Carolina University, 2011)Mitochondrial respiratory capacity and oxidative stress have been implicated in the development of insulin resistance (IR) and type II diabetes. A causative role of mitochondrial oxidative stress in the etiology of ...