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AMPK regulates basal skeletal muscle capillarization and VEGF expression, but is not necessary for the angiogenic response to exercise
(East Carolina UniversityEast Carolina University, 2008-12-15)
5 -AMP-activated protein kinase(AMPK)is a metabolic fuel sensor that monitors cellular energy charge, while the vasculature is important for maintaining cellular energy homeostasis. Mice with muscle-specific inactive AMPK ...
Physical Activity, Academic Performance, and Physical Self-Description in Adolescent Females
(East Carolina University, 2009)
Despite the many health benefits of being physically active, nearly a quarter of U.S. adults and adolescents report no participation in leisure-time physical activity. It is recommended that children and adolescents ...
Chronic low-frequency rTMS of primary motor cortex diminishes exercise training-induced gains in maximal voluntary force in humans
(East Carolina University, 2009)
Although there is consensus that the central nervous system mediates the increases in maximal voluntary force (maximal voluntary contraction, MVC) produced by resistance exercise, the involvement of the primary motor cortex ...
Changes in muscle strength, muscle fibre size and myofibrillar gene expression after immobilization and retraining in humans
(East Carolina University, 2000-01)
1. Changes in muscle strength, vastus lateralis fibre characteristics and myosin heavychain (MyoHC) gene expression were examined in 48 men and women following 3 weeks of knee immobilization and after 12 weeks of retraining ...
Does AMP-Activated Protein Kinase Negatively Mediate Aged Fast-Twitch Skeletal Muscle Mass?
(East Carolina University, 2008-10)
The activity of 5'-adenosine monophosphate–activated protein kinase, a negative regulator of cell size, is up-regulated with age in resting and overloaded fast-twitch skeletal muscle but not slowtwitch muscle. Here, we ...
Effect of exercise intensity and volume on persistence of insulin sensitivity during training cessation
(East Carolina University, 2009-04)
Effect of exercise intensity and volume on persistence of insulin sensitivity during training cessation. J Appl Physiol 106: 1079â 1085, 2009. First published February 5, 2009; doi:10.1152/japplphysiol.91262.2008. The ...
Social and Environmental Factors Associated with Preschoolers' Non-sedentary Physical Activity
(East Carolina University, 2009-01)
The two-fold purpose of the investigation was (1) to describe with direct observation data the physical
activity behaviors and the accompanying social and environmental events of those behaviors for children in preschools; ...
Deletion of the Protein Kinase A/Protein Kinase G Target SMTNL1 Promotes an Exercise-adapted Phenotype in Vascular Smooth Muscle
(East Carolina University, 2008-04-25)
In vivo protein kinases A and G (PKA and PKG) coordinately phosphorylate a broad range of substrates to mediate their various physiological effects. The functions of many of these substrates have yet to be defined genetically. ...
Factors Related to Objectively Measured Physical Activity in Preschool Children
(East Carolina University, 2009-05)
This study examined correlates of objectively measured physical activity (PA) in a diverse sample of preschool children (age 3–5 years; n=331). Accelerometer min·hr−1 of moderate-to-vigorous physical activity (MVPA) and ...
Metabolic Inflexibility in Skeletal Muscle With Obesity
(East Carolina University, 2009)
The skeletal muscle of obese individuals has a reduced capacity to oxidize lipids. The hypothesis to be tested in this dissertation is that the ability to regulate lipid oxidation in response to lipid exposure is impaired ...