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Effect of Acute Exercise or Fasting on Mitochondrial Function and High Fat Diet-Induced Insulin Resistance
(East Carolina University, 2009)
A high-fat diet leads to an accumulation of lipid in skeletal muscle, and the development of both mitochondrial dysfunction and insulin resistance. Recently, our lab reported that lipid overload leads to elevated ...
Muscles do more positive than negative work in human locomotion
(East Carolina University, 2007-10)
Muscle work during level walking and ascent and descent ramp and stairway walking was assessed in order to explore the proposition that muscles perform more positive than negative work during these locomotion tasks. Thirty ...
How do low horizontal forces produce disproportionately high torques in human locomotion?
(East Carolina University, 2008)
Although horizontal ground forces are only ~15% of vertical forces, they account for 47% and 33% of the metabolic cost in walking and running. To explain these disproportionately high metabolic costs we hypothesized that ...
Effect of Duodenal-Jejunal Bypass on Skeletal Muscle Insulin Signaling in Goto-Kakizaki Rats
(East Carolina University, 2009)
Gastric bypass surgery (RYGBP) for the treatment of obesity has proven to clinically reverse type 2 diabetes mellitus. RYGBP involves both gastric reduction and bypass of the proximal small intestine. Duodenal-Jejunal ...
Transcriptional regulation of muscle fatty acid-binding protein.
(East Carolina University, 1994-03-15)
Heart fatty acid-binding protein (H-FABP) is present in a wide variety of tissues but is found in the highest concentration in cardiac and red skeletal muscle. It has been proposed that the expression of H-FABP correlates ...
Modulation of H Reflex in Response to Voluntary Contraction of the Homologous Muscle in the Contralateral Limb
(East Carolina University, 2010)
Several studies reported that exercising one limb produces gains in motor output in the same muscle of the un-exercised, contralateral limb. This phenomenon is called cross education. There are also data to suggest that ...
No difference in the skeletal muscle angiogenic response
(East Carolina University, 2007-11)
Ischaemia-induced skeletalmuscle angiogenesis is impaired in aged compared with young mice. In humans, vascular endothelial growth factor (VEGF) mRNA and protein following an acute exercise bout are lower in aged compared ...
Intramuscular lipid oxidation and obesity
(East Carolina University, 2008-04)
There is an accumulating amount of evidence indicating that lipid oxidation is depressed in the skeletal muscle of obese individuals. Decrements in fatty acid oxidation (FAO) have been reported with obesity in models ranging ...
5'-AMP-Activated Protein Kinase and Eukaryotic Elongation Factor 2 Response to Resistance Exercise in Young Versus Old Men and Women
(East Carolina University, 2009)
It has been shown that skeletal muscle 5'-AMP-activated protein kinase (AMPK) phosphorylation and/or activity is more greatly elevated in response to resistance exercise or loading in aged rats, and that eukaryotic elongation ...
Increased Antagonist Coactivation-Related Hamstring Torque Reduces Maximal Knee Extension Torque in Healthy Old Adults
(East Carolina University, 2010)
As humans age, the ability to produce maximal voluntary torque decreases due to muscle atrophy (sarcopenia) and it is also known that advancing age alters the neural control of voluntary movement. One manifestation of the ...